Estrogen-related receptor alpha modulates lactate dehydrogenase activity in thyroid tumors

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Estrogen-related receptor alpha modulates lactate dehydrogenase activity in thyroid tumors is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...858683M
P356DOI10.1371/JOURNAL.PONE.0058683
P932PMC publication ID3596295
P698PubMed publication ID23516535
P5875ResearchGate publication ID236068652

P50authorJean-Fred FontaineQ80237224
P2093author name stringYves Malthièry
Naig Gueguen
Delphine Mirebeau-Prunier
Audrey Donnart
Frédérique Savagner
Caroline Jacques
Soazig Le Pennec
Nathalie Boutet-Bouzamondo
P2860cites workLactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancerQ46678525
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRalpha and gamma.Q51915435
Alterations in the activity and isozymic profile of human phosphofructokinase during malignant transformation in vivo and in vitro: transformation- and progression-linked discriminants of malignancy.Q53543339
Differences and similarities in binding of pyruvate and L-lactate in the active site of M4 and H4 isoforms of human lactate dehydrogenase.Q55053532
Mitochondrial coupling defect in Charcot-Marie-Tooth type 2A diseaseQ57898867
Analysis of phosphofructokinase subunits and isozymes in ascites tumor cells and its original tissue, murine mammary glandQ73450819
Pyruvate oxidation in thyroid tissueQ79380505
Peri-implantation lethality in mice lacking the PGC-1-related coactivator proteinQ83630485
The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesisQ24564869
Death-associated protein 3 is overexpressed in human thyroid oncocytic tumoursQ28248960
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolismQ28266830
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progressionQ28272474
Why do cancers have high aerobic glycolysis?Q28290710
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complexQ29617214
Otto Warburg's contributions to current concepts of cancer metabolismQ29617601
Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase.Q33228429
Cancer metabolism: facts, fantasy, and fictionQ35617179
Suppressing the activity of ERRalpha in 3T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptakeQ35893228
The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene.Q36572042
Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosisQ36671716
Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondriaQ37068084
Transcriptional control of energy homeostasis by the estrogen-related receptorsQ37229563
Is cancer a disease of abnormal cellular metabolism? New angles on an old ideaQ37305385
Modulating estrogen receptor-related receptor-alpha activity inhibits cell proliferationQ37358073
Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma?Q37801026
The mTOR protein as a target in thyroid cancer.Q37894106
Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defectsQ39585214
Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesisQ39612899
miR-378(∗) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathwayQ39648802
The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functionsQ39691060
Estrogen-related receptor alpha and PGC-1-related coactivator constitute a novel complex mediating the biogenesis of functional mitochondriaQ39753180
Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expressionQ40213332
Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblastsQ40579019
Establishment of a highly differentiated thyroid cancer cell line of Hürthle cell originQ41024303
The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolismQ41859202
Influence of mitochondrial inhibitors on the respiration and energy-dependent uptake of iodide by thyroid slicesQ42952551
Evolution of a gene. Multiple genes for LDH isozymes provide a model of the evolution of gene structure, function and regulationQ44888420
High-throughput real-time PCR.Q46541493
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)e58683
P577publication date2013-03-13
P1433published inPLOS OneQ564954
P1476titleEstrogen-related receptor alpha modulates lactate dehydrogenase activity in thyroid tumors
P478volume8

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cites work (P2860)
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Q38882978Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice
Q38806898In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma
Q36260554Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer
Q53697345Metabolic Reprogramming in Thyroid Carcinoma.
Q42738315Metabolic alterations due to IDH1 mutation in glioma: opening for therapeutic opportunities?
Q37688151MiR-34b-3 and miR-449a inhibit malignant progression of nasopharyngeal carcinoma by targeting lactate dehydrogenase A.
Q26801685Mitochondrial Energy Metabolism and Thyroid Cancers
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Q35604069Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue
Q35145025RNA interference targeting CD147 inhibits the proliferation, invasiveness, and metastatic activity of thyroid carcinoma cells by down-regulating glycolysis
Q41187544Reduction in ERRα is associated with lichen sclerosus and vulvar squamous cell carcinoma
Q38809719Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma
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Q40114063Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis
Q37565493miR-200b is a key regulator of tumor progression and metabolism targeting lactate dehydrogenase A in human malignant glioma

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