DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes

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DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1003260
P932PMC publication ID3610638
P698PubMed publication ID23555264
P5875ResearchGate publication ID236106130

P50authorLucy GloverQ56894162
Sam AlsfordQ56995979
David A. HornQ41534822
P2860cites workTelomeric expression sites are highly conserved in Trypanosoma bruceiQ21144222
The Genome of the African Trypanosome Trypanosoma bruceiQ22065798
Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombinationQ24646998
Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructureQ24676882
Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variationQ24815002
Antigenic variation in Plasmodium falciparumQ27972540
Telomeres avoid end detection by severing the checkpoint signal transduction pathwayQ28292872
Human subtelomeres are hot spots of interchromosomal recombination and segmental duplicationQ28768531
Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosomeQ56969779
A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma bruceiQ58846342
Involvement of telomeric sequences in chromosomal aberrationsQ77208384
Selection for activation of a new variant surface glycoprotein gene expression site in Trypanosoma brucei can result in deletion of the old oneQ77379889
Telomere structure and function in trypanosomes: a proposalQ79423572
Why are parasite contingency genes often associated with telomeres?Q29036018
How shelterin protects mammalian telomeresQ29615744
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaksQ33286997
TOPO3alpha influences antigenic variation by monitoring expression-site-associated VSG switching in Trypanosoma bruceiQ33632168
Variant surface glycoprotein RNA interference triggers a precytokinesis cell cycle arrest in African trypanosomesQ33853935
Predominance of duplicative VSG gene conversion in antigenic variation in African trypanosomesQ33959039
Identification of Trypanosoma brucei RMI1/BLAP75 homologue and its roles in antigenic variationQ34043078
Anticheckpoint pathways at telomeres in yeast.Q34161536
The transposition unit of variant surface glycoprotein gene 118 of Trypanosoma brucei. Presence of repeated elements at its border and absence of promoter-associated sequencesQ34254665
Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat ofTrypanosoma bruceiQ34260836
Antigenic variation and allelic exclusionQ34602633
Surviving the breakup: the DNA damage checkpoint.Q36521813
Transpositions and translocations induced by site-specific double-strand breaks in budding yeast.Q36522570
Subnuclear localization of the active variant surface glycoprotein gene expression site in Trypanosoma brucei.Q36523556
Analysis of the Trypanosoma brucei cell cycle by quantitative DAPI imaging.Q36808794
RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei.Q37169037
A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma bruceiQ37207551
Mammalian telomeres resemble fragile sites and require TRF1 for efficient replicationQ37297007
ATR/Mec1: coordinating fork stability and repair.Q37397197
Molecular mechanisms underlying the control of antigenic variation in African trypanosomesQ37795350
Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomesQ38315392
Trypanosomal histone γH2A and the DNA damage responseQ39025365
Microhomology-mediated deletion and gene conversion in African trypanosomesQ39025371
Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrestQ39025380
Telomere maintenance and length regulation in Trypanosoma brucei.Q39077195
Frequent loss of the active site during variant surface glycoprotein expression site switching in vitro in Trypanosoma brucei.Q39631219
Gene conversions mediating antigenic variation in Trypanosoma brucei can occur in variant surface glycoprotein expression sites lacking 70-base-pair repeat sequencesQ40020905
Cloning and characterization of chromosome breakpoints of Plasmodium falciparum: breakage and new telomere formation occurs frequently and randomly in subtelomeric genesQ40421458
A role for RAD51 and homologous recombination in Trypanosoma brucei antigenic variationQ40445788
Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma bruceiQ42321946
Two pathways of homologous recombination in Trypanosoma bruceiQ46247501
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P304page(s)e1003260
P577publication date2013-03-28
P1433published inPLOS PathogensQ283209
P1476titleDNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes
P478volume9

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cites work (P2860)
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Q61565641Trypanosoma brucei UMSBP2 is a single-stranded telomeric DNA binding protein essential for chromosome end protection
Q89686189Variant antigen diversity in Trypanosoma vivax is not driven by recombination