Transcriptional Regulation of Telomeric Expression Sites and Antigenic Variation in Trypanosomes

scientific article published in February 2018

Transcriptional Regulation of Telomeric Expression Sites and Antigenic Variation in Trypanosomes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2174/1389202918666170911161831
P932PMC publication ID5814960
P698PubMed publication ID29491740

P2093author name stringKen Stuart
Igor Cestari
P2860cites workTelomeric expression sites are highly conserved in Trypanosoma bruceiQ21144222
The Genome of the African Trypanosome Trypanosoma bruceiQ22065798
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAsQ24315942
Regulation of transcription termination by glucosylated hydroxymethyluracil, base J, in Leishmania major and Trypanosoma bruceiQ24489967
Meiosis and haploid gametes in the pathogen Trypanosoma bruceiQ24603969
Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in LeishmaniaQ24611470
The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse flyQ24625248
Active VSG expression sites in Trypanosoma brucei are depleted of nucleosomesQ24647409
Phylogenomic analyses support the monophyly of Excavata and resolve relationships among eukaryotic "supergroups"Q24657599
Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructureQ24676882
Epidemiology of human African trypanosomiasisQ27026504
NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functionsQ27319923
Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African TrypanosomeQ27345564
Structure of HDAC3 bound to co-repressor and inositol tetraphosphateQ27676653
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseQ27860668
Sumoylation: a regulatory protein modification in health and diseaseQ27865267
Yeast Isw1p forms two separable complexes in vivoQ27934130
SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeastQ27936734
Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcriptionQ28131683
Zinc finger peptides for the regulation of gene expressionQ28146002
Zinc finger proteins: new insights into structural and functional diversityQ28200120
Sticky fingers: zinc-fingers as protein-recognition motifsQ28282409
An enzymatic activity in the yeast Sir2 protein that is essential for gene silencingQ29617054
Transcriptional silencing in yeast is associated with reduced nucleosome acetylationQ29618497
Telomeric heterochromatin propagation and histone acetylation control mutually exclusive expression of antigenic variation genes in malaria parasitesQ30046041
Nuclear repositioning of the VSG promoter during developmental silencing in Trypanosoma bruceiQ30480413
ESAG11, a new VSG expression site-associated gene from Trypanosoma bruceiQ30659715
Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activityQ30860113
A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation.Q38870869
UBF complexes with phosphatidylinositol 4,5-bisphosphate in nucleolar organizer regions regardless of ongoing RNA polymerase I activityQ39025278
Activity of a trypanosome metacyclic variant surface glycoprotein gene promoter is dependent upon life cycle stage and chromosomal context.Q39574419
A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulationQ39646669
The PARP promoter of Trypanosoma brucei is developmentally regulated in a chromosomal context.Q39716007
A trypanosome metacyclic VSG gene promoter with two functionally distinct, life cycle stage-specific activities.Q39723530
RNA polymerase I transcribes procyclin genes and variant surface glycoprotein gene expression sites in Trypanosoma bruceiQ39774504
Expression site attenuation mechanistically links antigenic variation and development in Trypanosoma brucei.Q39787815
Transcriptional regulation of metacyclic variant surface glycoprotein gene expression during the life cycle of Trypanosoma brucei.Q40017482
Localization of the modified base J in telomeric VSG gene expression sites of Trypanosoma bruceiQ40443898
A variant histone H3 is enriched at telomeres in Trypanosoma brucei.Q40496499
A novel DNA nucleotide inTrypanosoma bruceionly present in the mammalian phase of the life-cycleQ40503295
Alpha-amanitin-resistant transcription units in trypanosomes: a comparison of promoter sequences for a VSG gene expression site and for the ribosomal RNA genesQ40507388
The promoter for the procyclic acidic repetitive protein (PARP) genes of Trypanosoma brucei shares features with RNA polymerase I promotersQ40655056
Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites.Q40692004
VSG gene expression site control in insect form Trypanosoma bruceiQ40793913
TDP1 is an HMG chromatin protein facilitating RNA polymerase I transcription in African trypanosomesQ41123793
Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma bruceiQ41208510
Inactivation and reactivation of a variant-specific antigen gene in cyclically transmitted Trypanosoma bruceiQ41389068
Procyclin gene expression and loss of the variant surface glycoprotein during differentiation of Trypanosoma bruceiQ41571556
Trypanosoma brucei histone H1 inhibits RNA polymerase I transcription and is important for parasite fitness in vivoQ41934797
Identification of the ISWI Chromatin Remodeling Complex of the Early Branching Eukaryote Trypanosoma brucei.Q41944599
Trypanosoma brucei TIF2 suppresses VSG switching by maintaining subtelomere integrityQ42065326
Direct modification and activation of a nuclear receptor-PIP₂ complex by the inositol lipid kinase IPMK.Q42077086
The FACT subunit TbSpt16 is involved in cell cycle specific control of VSG expression sites in Trypanosoma bruceiQ42254608
Trypanosoma brucei Orc1 is essential for nuclear DNA replication and affects both VSG silencing and VSG switching.Q42283703
NLP is a novel transcription regulator involved in VSG expression site control in Trypanosoma bruceiQ42704211
A novel ISWI is involved in VSG expression site downregulation in African trypanosomesQ42805612
A proposed mechanism for promoter-associated DNA rearrangement events at a variant surface glycoprotein gene expression siteQ43183326
The anatomy and transcription of a telomeric expression site for variant-specific surface antigens in T. bruceiQ43544439
Organization of telomeres during the cell and life cycles of Trypanosoma bruceiQ44048505
Cytokinesis of Trypanosoma brucei bloodstream forms depends on expression of adenylyl cyclases of the ESAG4 or ESAG4-like subfamilyQ44238142
Capturing the variant surface glycoprotein repertoire (the VSGnome) of Trypanosoma brucei Lister 427.Q44314256
Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II.Q44658575
Two pathways of homologous recombination in Trypanosoma bruceiQ46247501
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparumQ46429981
Loss of the mono-allelic control of the VSG expression sites during the development of Trypanosoma brucei in the bloodstreamQ46794890
Antigenic variation in African trypanosomes by gene replacement or activation of alternate telomeresQ46839275
The anatomy and transcription of a monocistronic expression site for a metacyclic variant surface glycoprotein gene in Trypanosoma bruceiQ47958504
The putative promoter for a metacyclic VSG gene in African trypanosomesQ48073005
The architecture of variant surface glycoprotein gene expression sites in Trypanosoma bruceiQ48294559
Multiple procyclin isoforms are expressed differentially during the development of insect forms of Trypanosoma brucei.Q48341043
A novel heterodimeric transferrin receptor encoded by a pair of VSG expression site-associated genes in T. bruceiQ49096603
A developmentally regulated position effect at a telomeric locus in Trypanosoma brucei.Q52204732
Two mechanisms of expression of a predominant variant antigen gene of Trypanosoma brucei.Q53911004
Transcription of Leishmania major Friedlin chromosome 1 initiates in both directions within a single region.Q55036574
Transient adenylate cyclase activation accompanies differentiation of Trypanosoma brucei from bloodstream to procyclic formsQ58844181
A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma bruceiQ58846342
Telomere looping permits gene activation by a downstream UAS in yeastQ59070403
Expression-site-associated gene 8 (ESAG8) of Trypanosoma brucei is apparently essential and accumulates in the nucleolusQ61519295
The surface coat of procyclic Trypanosoma brucei: Programmed expression and proteolytic cleavage of procyclin in the tsetse flyQ61790526
A novel telomeric gene conversion in Trypanosoma bruceiQ69683303
Trypanosoma brucei: frequent loss of a telomeric variant surface glycoprotein geneQ69948331
A ribosomal DNA promoter replacing the promoter of a telomeric VSG gene expression site can be efficiently switched on and off in T. bruceiQ71806491
Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeastQ72560058
Isolation of the repertoire of VSG expression site containing telomeres of Trypanosoma brucei 427 using transformation-associated recombination in yeastQ33208595
The promoter for a variant surface glycoprotein gene expression site in Trypanosoma bruceiQ33257564
A histone methyltransferase modulates antigenic variation in African trypanosomes.Q33348749
Nucleosomes are depleted at the VSG expression site transcribed by RNA polymerase I in African trypanosomesQ33585929
Alpha-amanitin resistant transcription of protein coding genes in insect and bloodstream form Trypanosoma bruceiQ33591516
The endocytic activity of the flagellar pocket in Trypanosoma brucei is regulated by an adjacent phosphatidylinositol phosphate kinase.Q33613389
The Transcriptome of the Human Pathogen Trypanosoma brucei at Single-Nucleotide ResolutionQ33691492
Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in Trypanosoma bruceiQ33790035
Trypanosome telomeres are protected by a homologue of mammalian TRF2.Q33836828
Histone H3 trimethylated at lysine 4 is enriched at probable transcription start sites in Trypanosoma bruceiQ33875106
Trypanosoma brucei variant surface glycoprotein regulation involves coupled activation/inactivation and chromatin remodeling of expression sitesQ33890790
Architectural organization in the interphase nucleus of the protozoan Trypanosoma brucei: location of telomeres and mini-chromosomesQ33924213
Identification of the glucosyltransferase that converts hydroxymethyluracil to base J in the trypanosomatid genomeQ33931238
Telomere folding is required for the stable maintenance of telomere position effects in yeastQ33966202
Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription.Q34036364
The pre-mRNA splicing machinery of trypanosomes: complex or simplified?Q34055168
beta-D-glucosyl-hydroxymethyluracil: a novel modified base present in the DNA of the parasitic protozoan T. bruceiQ34061024
Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sitesQ34080058
Life without transcriptional control? From fly to man and back againQ34086628
Histone deacetylases play distinct roles in telomeric VSG expression site silencing in African trypanosomes.Q34138783
t-loops at trypanosome telomeres.Q34271330
The impact of mutation and gene conversion on the local diversification of antigen genes in African trypanosomesQ34317540
Mosaic VSGs and the scale of Trypanosoma brucei antigenic variation.Q34357533
Tb927.10.6900 encodes the glucosyltransferase involved in synthesis of base J in Trypanosoma bruceiQ34389666
The in vivo dynamics of antigenic variation in Trypanosoma bruceiQ34468884
Histone H1 plays a role in heterochromatin formation and VSG expression site silencing in Trypanosoma brucei.Q34469008
A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesienseQ34484958
MCM-BP is required for repression of life-cycle specific genes transcribed by RNA polymerase I in the mammalian infectious form of Trypanosoma brucei.Q34602897
SUMOylation by the E3 ligase TbSIZ1/PIAS1 positively regulates VSG expression in Trypanosoma brucei.Q34634847
DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomesQ34649711
Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei.Q35066514
Niche metabolism in parasitic protozoaQ35113597
Nuclear lipid signallingQ35120151
TbISWI regulates multiple polymerase I (Pol I)-transcribed loci and is present at Pol II transcription boundaries in Trypanosoma brucei.Q35138983
Leishmania major chromosome 3 contains two long convergent polycistronic gene clusters separated by a tRNA geneQ35186026
A major surface glycoprotein of trypanosoma brucei is expressed transiently during development and can be regulated post-transcriptionally by glycerol or hypoxia.Q35187690
Chromatin assembly by DNA-translocating motorsQ35201456
The sequence and analysis of Trypanosoma brucei chromosome II.Q35222720
Inositol phosphate pathway controls transcription of telomeric expression sites in trypanosomesQ35669366
DNA Recombination Strategies During Antigenic Variation in the African Trypanosome.Q35672273
Synchronous expression of individual metacyclic variant surface glycoprotein genes in Trypanosoma bruceiQ35751982
Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma bruceiQ35900453
Base J and H3.V Regulate Transcriptional Termination in Trypanosoma bruceiQ35900489
Trypanosoma brucei TIF2 and TRF Suppress VSG Switching Using Overlapping and Independent MechanismsQ36039757
Multifunctional class I transcription in Trypanosoma brucei depends on a novel protein complexQ36177213
FACT plays a major role in histone dynamics affecting VSG expression site control in Trypanosoma brucei.Q36221396
Gene transcription in trypanosomesQ36374333
Characterization of a novel class I transcription factor A (CITFA) subunit that is indispensable for transcription by the multifunctional RNA polymerase I of Trypanosoma bruceiQ36506502
ATP-dependent chromatin remodeling complexes in Drosophila.Q36527443
The PARP and rRNA promoters of Trypanosoma brucei are composed of dissimilar sequence elements that are functionally interchangeableQ36664882
Genome-wide analysis reveals extensive functional interaction between DNA replication initiation and transcription in the genome of Trypanosoma brucei.Q36713460
The epigenetic regulation of mammalian telomeresQ36761196
ATP-dependent chromatin remodeling enzymes: two heads are not better, just differentQ36808347
Nuclear architecture underlying gene expression in Trypanosoma bruceiQ36811798
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomesQ37065139
JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomesQ37128117
Silencing subtelomeric VSGs by Trypanosoma brucei RAP1 at the insect stage involves chromatin structure changesQ37148511
RAP1 is essential for silencing telomeric variant surface glycoprotein genes in Trypanosoma brucei.Q37169037
Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma bruceiQ37194366
A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma bruceiQ37207551
Cohesin regulates VSG monoallelic expression in trypanosomesQ37280418
A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma bruceiQ37367700
The Mcm complex: unwinding the mechanism of a replicative helicase.Q37451513
Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression.Q37507562
Promoter occupancy of the basal class I transcription factor A differs strongly between active and silent VSG expression sites in Trypanosoma brucei.Q37631833
Trypanosome spliced leader RNA genes contain the first identified RNA polymerase II gene promoter in these organismsQ38678733
Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei.Q38870836
P433issue2
P304page(s)119-132
P577publication date2018-02-01
P1433published inCurrent GenomicsQ5195047
P1476titleTranscriptional Regulation of Telomeric Expression Sites and Antigenic Variation in Trypanosomes
P478volume19

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cites work (P2860)
Q61496438A single-point mutation in the RNA-binding protein 6 generates Trypanosoma brucei metacyclics that are able to progress to bloodstream forms in vitro
Q90287090African trypanosomes expressing multiple VSGs are rapidly eliminated by the host immune system
Q92264842Dynamic colocalization of 2 simultaneously active VSG expression sites within a single expression-site body in Trypanosoma brucei
Q50420470Inositol polyphosphate multikinase regulation of Trypanosoma brucei life stage development
Q93015093Nuclear Phosphatidylinositol 5-Phosphatase Is Essential for Allelic Exclusion of Variant Surface Glycoprotein Genes in Trypanosomes
Q92375557Phosphoinositide signaling and regulation in Trypanosoma brucei: Specialized functions in a protozoan pathogen
Q59789575Schizont transcriptome variation among clinical isolates and laboratory-adapted clones of the malaria parasite Plasmodium falciparum
Q99571785TbRAP1 has an unusual duplex DNA binding activity required for its telomere localization and VSG silencing
Q89899802Trypanosoma brucei RAP1 Has Essential Functional Domains That Are Required for Different Protein Interactions

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