Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle

scientific article published on December 1, 1977

Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0006-3495(77)85554-9
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0006349577855549?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0006349577855549?httpAccept=text/xml
https://europepmc.org/articles/PMC1473363
https://europepmc.org/articles/PMC1473363?pdf=render
P932PMC publication ID1473363
P698PubMed publication ID21711

P2093author name stringB. Hille
W. Schwarz
P. T. Palade
P2860cites workThe buffer value of rat diaphragm muscle tissue determined by Pco2, equilibration of homogenatesQ71818601
Electrical activity and intracellular sodium concentration in frog muscleQ73261004
Potassium chloride movement and the membrane potential of frog muscleQ79130064
Measurement of current-voltage relations in the membrane of the giant axon of LoligoQ22337076
Hydrogen Ion Buffers for Biological Research*Q28257659
Ionic Mobility in Muscle CellsQ34232212
The pH-dependent rate of action of local anesthetics on the node of RanvierQ34559874
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reactionQ34684384
The site of action and active form of local anesthetics. II. Experiments with quaternary compoundsQ34703281
ELEMENTARY STEPS IN ENZYME REACTIONS (AS STUDIED BY RELAXATION SPECTROMETRY).Q35441254
Ionic Blockage of Sodium Channels in NerveQ36388606
Kinetic and pharmacological properties of the sodium channel of frog skeletal muscleQ36407628
An improved vaseline gap voltage clamp for skeletal muscle fibersQ36407642
Direct measurement of the intracellular pH of mammalian cardiac muscleQ39132313
Saxitoxin and procaine act independently on separate sites of the sodium channelQ39585641
Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEAQ41066031
The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of LidocaineQ41920650
The effects of pH on penetration and action of procaine 14C, atropine 3H, n-butanol 14C and halothane 14C in single giant axons of the squidQ42234162
The binding of labelled saxitoxin to the sodium channels in nerve membranesQ44902342
The binding of labelled tetrodotoxin to non-myelinated nerve fibres.Q52439651
Local anesthetics: effects on permeability properties of nodal membrane in myelinated nerve fibres from xenopus. Potential clamp experiments.Q52723905
The active form of local anesthetics.Q52767720
Effect of procaine on electrical properties of squid axon membrane.Q52771198
Effects of calcium ions and local anesthetics on electrical properties of Purkinje fibres.Q52776323
Local anesthetics. I. The blocking potencies of some local anesthetics and of butyl alcohol determined on peripheral nerves.Q52777947
Intracellular pH, H ion flux and H ion permeability coefficient in bullfrog toe muscleQ69091222
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectsodiumQ658
biophysicsQ7100
AnuraQ53636
P1104number of pages26
P304page(s)343-368
P577publication date1977-12-01
P1433published inBiophysical JournalQ2032955
P1476titleLocal anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle
P478volume20

Reverse relations

cites work (P2860)
Q49486564A protein-conducting channel in the endoplasmic reticulum
Q34257683A quantitative description of QX222 blockade of sodium channels in squid axons
Q40124099Acetylcholine receptor kinetics
Q51789203Action of benzocaine on sodium channels of frog nodes of Ranvier treated with chloramine-T.
Q51424821Alkalinizing local anesthetic does not decrease pain during injection for dorsal penile nerve block.
Q47250431Antagonism by local anesthetics of sodium channel activators in the presence of scorpion toxins: two mechanisms for competitive inhibition
Q53943964Antiarrhythmic drugs and cardiac ion channels: mechanisms of action.
Q28306235Aprindine blocks the sodium current in guinea-pig ventricular myocytes
Q72394790Asymmetric proton block of inward rectifier K channels in skeletal muscle
Q34778955Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart
Q41549896Block of sodium conductance by n-octanol in crayfish giant axons
Q35872351Blockade by local anaesthetics of the single Ca(2+)-activated K+ channel in rat hippocampal neurones
Q37082082Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve
Q39679803Cardiac arrhythmia, sudden death, and psychoactive agents
Q72386538Cat ventricular muscle treated with D600: characteristics of calcium channel block and unblock
Q34125687Characterization of cocaine-induced block of cardiac sodium channels
Q34575837Characterization of concentration- and use-dependent effects of quinidine from conduction delay and declining conduction velocity in canine Purkinje fibers
Q40158538Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels
Q34018832Charged tetracaine as an inactivation enhancer in batrachotoxin-modified Na+ channels
Q41552906Chemical modification of sodium channel surface charges in frog skeletal muscle by trinitrobenzene sulphonic acid
Q28476574Classification of drugs based on properties of sodium channel inhibition: a comparative automated patch-clamp study
Q36412399Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues
Q36015209Computational biology in the study of cardiac ion channels and cell electrophysiology.
Q41953808Conotoxins as sensors of local pH and electrostatic potential in the outer vestibule of the sodium channel
Q51866579Current concepts of the mechanism of action of local anesthetics.
Q33907181Differences in steady-state inactivation between Na channel isoforms affect local anesthetic binding affinity
Q40460868Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway.
Q42184420Direct inhibition of the actomyosin motility by local anesthetics in vitro
Q40335968Direct quantification of apparent binding indices from quinidine-induced in vivo conduction delay in canine myocardium
Q34017596Distinct local anesthetic affinities in Na+ channel subtypes
Q72898354Effect of RP 30356 on the fast inward Na current in frog atrial fibres
Q41053039Effect of a trial pharmaceutical solution on reversing sensations after using lidocain: An animal study
Q53968833Effect of procainamide on transmembrane action potentials in guinea-pig papillary muscles as affected by external potassium concentration
Q48690483Effects of amphipathic drugs onl-[3H]glutamate binding to synaptic membranes and the purified binding protein
Q60690949Enantioselective relief of neuropathic pain by systemic mexiletine in the rat
Q77731265Enhancing effects of salicylate on tonic and phasic block of Na+ channels by class 1 antiarrhythmic agents in the ventricular myocytes and the guinea pig papillary muscle
Q42856497Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration
Q48335317Exploring the role of pH in modulating the effects of lidocaine in virtual ischemic tissue
Q27324485Exploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computation
Q52702876Fast frequency-dependent block of action potential upstroke in rabbit atrium by small local anesthetics
Q39769656Gating currents and charge movements in excitable membranes
Q46555656High selectivity of calcium channels in single dialysed heart cells of the guinea-pig
Q41447574Histochemical study of calcium on T-tubule membranes and in the sarcoplasmic reticulum, in frog twitch muscle fibres at rest and during activity
Q28374367Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels
Q67526951Imipramine and 2-hydroxyimipramine: comparative cardiotoxicity and pharmacokinetics in swine
Q46390376Inactivation of human sodium channels and the effect of tocainide
Q36410344Influence of pHo on calcium channel block by amlodipine, a charged dihydropyridine compound. Implications for location of the dihydropyridine receptor
Q33152183Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels
Q40983615Inhibition by local anesthetics of Ca2+ channels in rat anterior pituitary cells
Q36409628Inhibition of sodium currents by local anesthetics in chloramine-T-treated squid axons. The role of channel activation
Q46702076Inhibiton of $$\dot V_{\max } $$ of the action potential by propafenone and its voltage-, time- and pH-dependence in mammalian ventricular myocardium
Q51875266Interaction of lidocaine and benzocaine in blocking sodium channels
Q51864195Interaction of spin-labeled local anesthetics with the sodium channel of squid axon membranes.
Q40300883Interactions between quaternary lidocaine, the sodium channel gates, and tetrodotoxin
Q36409432Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells
Q55687858Intramuscular infiltration of a local anesthetic, lidocaine, does not result in adverse behavioural side effects in rainbow trout.
Q41908034Irreversible inhibition of sodium current and batrachotoxin binding by a photoaffinity-derivatized local anesthetic
Q34126144Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaine
Q36433539Kinetics of 9-aminoacridine block of single Na channels
Q52542989Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potentials.
Q39631657Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence
Q41556598Lidocaine block of cardiac sodium channels
Q51787811Local anaesthetic effects of benzene and structurally related molecules, including benzocaine, on the squid giant axon.
Q34656530Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
Q39340842Local anesthetic inhibition of a bacterial sodium channel
Q36408497Local anesthetics QX 572 and benzocaine act at separate sites on the batrachotoxin-activated sodium channel
Q37362215Local anesthetics as effectors of allosteric gating. Lidocaine effects on inactivation-deficient rat skeletal muscle Na channels
Q37023303Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel.
Q42855770Local anesthetics: a century of progress
Q46928441Mechanism of inhibition of the Na current by tocainide in guinea-pig isolated ventricular cells
Q42269886Mechanism of inhibition of the sodium current by bepridil in guinea-pig isolated ventricular cells
Q47230575Mechanisms of Drug Binding to Voltage-Gated Sodium Channels
Q34534868Mechanisms of use-dependent block of sodium channels in excitable membranes by local anesthetics
Q35006735Membrane porters of ATP-binding cassette transport systems are polyphyletic
Q38997044Molecular Determinants of BK Channel Functional Diversity and Functioning
Q41160240Molecular and structural basis of resting and use-dependent block of sodium current defined using disopyramide analogues
Q47422850Molecular determinants of prokaryotic voltage-gated sodium channels for recognition of local anesthetics
Q30474717Molecular disruptions of the panglial syncytium block potassium siphoning and axonal saltatory conduction: pertinence to neuromyelitis optica and other demyelinating diseases of the central nervous system
Q34535788Na channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axons
Q28365692Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state
Q37365724Pharmacological targeting of long QT mutant sodium channels
Q72418552Potency of 3,4-Diaminopyridine and 4-aminopyridine on mammalian neuromuscular transmission and the effect of pH changes
Q48657941Procaine actions on tetrodotoxin sensitive and insensitive leech neurons
Q51875256Properties of toxin-resistant sodium channels produced by chemical modification in frog skeletal muscle
Q42665311Quinacrine (mepacrine) action at frog end-plate
Q24555201Quinine blocks specific gap junction channel subtypes
Q39219867Rates of block by procaine and benzocaine and the procaine-benzocaine interaction at the node of Ranvier
Q24634668Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias
Q37553511Sidedness of carbamazepine accessibility to voltage-gated sodium channels
Q41243945Slow calcium and potassium currents in frog skeletal muscle: their relationship and pharmacologic properties
Q24595359Sodium Channel Molecular Conformations and Antiarrhythmic Drug Affinity
Q37605350Sodium channel blockers for the treatment of neuropathic pain
Q51867596Sodium current depression by lidocaine and quinidine in isolated ventricular cells
Q39805666Some aspects of the pharmacology of sodium channels in nerve membrane. Process of inactivation
Q40923244State-Dependent Inhibition of Sodium Channels by Local Anesthetics: A 40-Year Evolution
Q37384589State-dependent block of Na+ channels by articaine via the local anesthetic receptor
Q73118055Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers
Q51714710Stereoselective interaction of tocainide and its chiral analogs with the sodium channels in human myoballs.
Q40170517Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block.
Q37860361Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review
Q40732149Temperature experiments on nerve and muscle membranes of frogs. Indications for a phase transition
Q42847976The activation gate of the sodium channel controls blockade and deblockade by disopyramide in rabbit Purkinje fibres
Q51868436The blockade of Vmax of the atrioventricular action potential produced by the slow channel inhibitors verapamil and nifedipine.
Q73898558The blocking mechanism of sodium currents by a new class I antiarrhythmic drug, Ro 22-9194, in isolated guinea-pig ventricular myocytes
Q36003857The channel-blocking action of methonium compounds on rat submandibular ganglion cells
Q35573700The channel-blocking action of methonium compounds on rat submandibular ganglion cells. 1983
Q51704198The different use dependences of tocainide and benzocaine are correlated with different effects on sodium channel inactivation
Q51861121The effect of yohimbine on sodium and gating currents in frog ranvier node membrane
Q46339296The impact of environment and resonance effects on the site of protonation of aminobenzoic acid derivatives.
Q51668201The interaction of local anesthetics with the ryanodine receptor of the sarcoplasmic reticulum.
Q72098669The interaction of potassium with the activation of anomalous rectification in frog muscle membrane
Q41768716Tonic and phasic block of neuronal sodium currents by 5-hydroxyhexano-2',6'-xylide, a neutral lidocaine homologue
Q51652331Ultra-deep blockade of Na+ channels by a quaternary ammonium ion: catalysis by a transition-intermediate state?
Q53461325Updated Review of Fish Analgesia.
Q34016917Use-dependent inhibition of Na+ currents by benzocaine homologs
Q39218475Uses and Doses of Local Anesthetics in Fish, Amphibians, and Reptiles
Q37326589Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity
Q51874590Voltage-clamp experiments in normal and denervated mammalian skeletal muscle fibres.
Q34254425n-Alkanols potentiate sodium channel inactivation in squid giant axons
Q34126151pH-dependent binding of local anesthetics in single batrachotoxin-activated Na+ channels. Cocaine vs. quaternary compounds
Q77654452pH-dependent block of the L-type Ca2+ channel current by diltiazem in human mesenteric arterial myocytes