Computational biology in the study of cardiac ion channels and cell electrophysiology.

scientific article

Computational biology in the study of cardiac ion channels and cell electrophysiology. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1017/S0033583506004227
P932PMC publication ID1994938
P698PubMed publication ID16848931

P50authorJonathan R. SilvaQ42318035
P2093author name stringYoram Rudy
P2860cites workMiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmiaQ22009462
Basic Mechanisms of Cardiac Impulse Propagation and Associated ArrhythmiasQ22337019
A quantitative description of membrane current and its application to conduction and excitation in nerveQ22337072
Measurement of current-voltage relations in the membrane of the giant axon of LoligoQ22337076
Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channelQ24292184
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmiasQ24311437
The inward rectification mechanism of the HERG cardiac potassium channelQ24320034
Mutations in the hminK gene cause long QT syndrome and suppress IKs functionQ24323571
Voltage-dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunitsQ24653858
A single Na(+) channel mutation causing both long-QT and Brugada syndromesQ28139738
Reconstruction of the electrical activity of cardiac Purkinje fibresQ28202575
Identification of Ser38 as the site in cardiac sarcoplasmic reticulum Ca(2+)-ATPase that is phosphorylated by Ca2+/calmodulin-dependent protein kinaseQ28238989
Mutation of the gene for IsK associated with both Jervell and Lange-Nielsen and Romano-Ward forms of Long-QT syndromeQ28260101
ATP-regulated K+ channels in cardiac muscleQ28265565
Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potentialQ28345142
Two open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channelsQ28364994
The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytesQ32077745
Pause induced early afterdepolarizations in the long QT syndrome: a simulation studyQ33145051
Risk stratification in the long-QT syndrome.Q33148941
Drug-induced prolongation of the QT intervalQ33151147
Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channelsQ33152183
Catecholaminergic polymorphic ventricular tachycardia.Q33152560
Molecular mechanism for an inherited cardiac arrhythmiaQ33173678
Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy.Q33174548
Right bundle-branch block and ST-segment elevation in leads V1 through V3: a marker for sudden death in patients without demonstrable structural heart diseaseQ33175526
The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heartQ33722232
Structure and function of the cardiac sodium channelsQ33758984
Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevationQ33876613
Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependentQ33877950
A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cellQ34108342
Early afterdepolarizations in cardiac myocytes: mechanism and rate dependenceQ34128689
The Brugada syndrome: ionic basis and arrhythmia mechanismsQ34171444
Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation studyQ34173006
Molecular biology of sodium channels and their role in cardiac arrhythmiasQ34175659
Ionic charge conservation and long-term steady state in the Luo-Rudy dynamic cell modelQ34177010
A mathematical model of the electrophysiological alterations in rat ventricular myocytes in type-I diabetesQ34180327
A computational model of the human left-ventricular epicardial myocyteQ34186985
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.Q34187747
Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. A weaker IKs contributes to the longer action potential of the M cellQ34318866
Dynamics of cAMP-dependent protein kinaseQ34465979
Electrical heterogeneity within the ventricular wallQ34479868
Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscleQ34656051
Autonomic aspects of arrhythmogenesis: the enduring and the new.Q34806259
Structural basis of two-stage voltage-dependent activation in K+ channelsQ34809127
Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond.Q34863518
Activation of protein kinase by physiological concentrations of cyclic AMP.Q35112983
Long QT syndrome: novel insights into the mechanisms of cardiac arrhythmiasQ35219529
Cyclic AMP-dependent protein kinase I: cyclic nucleotide binding, structural changes, and release of the catalytic subunitsQ35325475
Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserveQ35676902
Ionic current basis of electrocardiographic waveforms: a model studyQ35742067
Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell modelQ35750331
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.Q35772979
Modelling and imaging cardiac repolarization abnormalitiesQ35783131
Inactivation of the sodium channel. I. Sodium current experimentsQ41897655
Voltage-dependent activation of the inward-rectifier potassium channel in the ventricular cell membrane of guinea-pig heartQ41906588
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitorsQ41929087
Inactivation of the sodium channel. II. Gating current experimentsQ41933393
Effects of modification of the hydrophobic C-1-C-16 segment of tautomycin on its affinity to type-1 and type-2A protein phosphatasesQ42158301
Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation.Q42441516
Effects of III-IV linker mutations on human heart Na+ channel inactivation gatingQ42597128
Changes in sodium channel gating produced by point mutations in a cytoplasmic linkerQ42632424
A critical role for the S4-S5 intracellular loop in domain IV of the sodium channel alpha-subunit in fast inactivationQ42670296
Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytesQ42822434
Density and kinetics of I(Kr) and I(Ks) in guinea pig and rabbit ventricular myocytes explain different efficacy of I(Ks) blockade at high heart rate in guinea pig and rabbit: implications for arrhythmogenesis in humansQ43714041
Abrupt rate accelerations or premature beats cause life-threatening arrhythmias in mice with long-QT3 syndrome.Q43726773
Calcium-activated non-selective cation channel in ventricular cells isolated from adult guinea-pig heartsQ43850390
RYR2 and CASQ2 mutations in patients suffering from catecholaminergic polymorphic ventricular tachycardiaQ44292826
Na(+)-activated K+ current in cardiac cells: rectification, open probability, block and role in digitalis toxicityQ44457213
Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes.Q44486244
Role of individual ionic current systems in ventricular cells hypothesized by a model studyQ44523434
Modeling beta-adrenergic control of cardiac myocyte contractility in silicoQ44583904
ATP-sensitive potassium channel modulation of the guinea pig ventricular action potential and contractionQ44894233
Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue.Q45140727
A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interactionQ45172101
An ionic model for rhythmic activity in small clusters of embryonic chick ventricular cellsQ45263664
A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiationQ46168705
Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulationQ46178464
Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunitQ46196123
Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential durationQ46239877
Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardiumQ46299957
Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarizationQ46336732
A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changesQ46410988
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes.Q46599516
Role of aiNa in positive force-frequency staircase in guinea pig papillary muscleQ46852814
Kinetic properties of the cardiac T-type calcium channel in the guinea-pigQ46922673
Four potassium channel mutations account for 73% of the genetic spectrum underlying long-QT syndrome (LQTS) and provide evidence for a strong founder effect in FinlandQ47398470
Computer model of action potential of mouse ventricular myocytes.Q47606383
Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model.Q47747371
Simulation study of cellular electric properties in heart failureQ47951135
Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity.Q48707184
Mathematical model of an adult human atrial cell: the role of K+ currents in repolarizationQ48732077
Novel gain-of-function mechanism in K(+) channel-related long-QT syndrome: altered gating and selectivity in the HERG1 N629D mutantQ48896292
Pathways of HERG inactivationQ48913019
Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivationQ48921379
Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivationQ48933322
Multiple mechanisms of Na+ channel--linked long-QT syndromeQ49013113
Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK.Q50741839
Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel alpha-subunit gene (SCN5A) to band 3p21.Q51614266
Two kinds of calcium-induced release of calcium from the sarcoplasmic reticulum of skinned cardiac cellsQ35857333
A mutation in segment IVS6 disrupts fast inactivation of sodium channelsQ35977279
Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanismQ36019333
Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels.Q36266824
Molecular physiology of cardiac repolarizationQ36267771
Rate-limiting steps in the beta-adrenergic stimulation of cardiac calcium currentQ36411360
Shaker potassium channel gating. II: Transitions in the activation pathwayQ36411437
Shaker potassium channel gating. III: Evaluation of kinetic models for activationQ36411441
The Na+ channel inactivation gate is a molecular complex: a novel role of the COOH-terminal domain.Q36412518
Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurementsQ36412534
Gating of IsK expressed in Xenopus oocytes depends on the amount of mRNA injectedQ36435283
Single-channel properties of IKs potassium channelsQ36436185
Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndromeQ36436190
Gating charges in the activation and inactivation processes of the HERG channelQ36445757
A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmiaQ36446420
Anti-minK Antisense Decreases the Amplitude of the Rapidly Activating Cardiac Delayed Rectifier K + CurrentQ36684678
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivationQ37301303
Pharmacological targeting of long QT mutant sodium channelsQ37365724
Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinaseQ38293222
Inhibition of cardiac delayed rectifier K+ currents by an antisense oligodeoxynucleotide against IsK (minK) and over-expression of IsK mutant D77N in neonatal mouse heartsQ38298221
A model of cardiac electrical activity incorporating ionic pumps and concentration changesQ38383023
Compartmentalization of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in heart tissueQ39148490
Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscleQ39952712
The hormonal control of glycogen metabolism: The amino acid sequence at the phosphorylation site of protein phosphatase inhibitor-1Q40072524
Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channelsQ40156271
Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium-calmodulin-dependent phosphorylationsQ40265186
Cardiac T-type calcium current: pharmacology and roles in cardiac tissuesQ40623976
Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmiaQ40655450
Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel.Q40812589
Enhanced Na(+) channel intermediate inactivation in Brugada syndromeQ40849528
Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: A computational analysisQ40865508
Molecular genetic insights into cardiovascular diseaseQ40939557
HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defectsQ41018746
Multiple effects of KPQ deletion mutation on gating of human cardiac Na+ channels expressed in mammalian cellsQ41037340
Background potassium current active during the plateau of the action potential in guinea pig ventricular myocytesQ41084550
The vmax of the Ca2+-ATPase of cardiac sarcoplasmic reticulum (SERCA2a) is not altered by Ca2+/calmodulin-dependent phosphorylation or by interaction with phospholambanQ41191898
A model for early afterdepolarizations: induction with the Ca2+ channel agonist Bay K 8644.Q41251946
Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ currentQ41256047
Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signalsQ41469189
Characterization and Regulation of ?1-Adrenergic Receptors in a Human Neuroepithelioma Cell LineQ41698642
Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cellsQ41749919
Dynamical mechanisms of pacemaker generation in IK1-downregulated human ventricular myocytes: insights from bifurcation analyses of a mathematical modelQ41872690
Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation.Q51819325
Cardiac-enriched LIM domain protein fhl2 is required to generate I(Ks) in a heterologous system.Q51843125
Hysteresis and bistability in the direct transition from 1:1 to 2:1 rhythm in periodically driven single ventricular cells.Q52015370
Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling.Q52073425
A theory for the membrane potential of living cells.Q52076833
A conservation principle and its effect on the formulation of Na-Ca exchanger current in cardiac cells.Q52252561
A discussion about the DiFrancesco-Noble model.Q52252564
Postextrasystolic potentiation of the isolated canine left ventricle. Relationship to mechanical restitution.Q52431032
A mathematical model of electrophysiological activity in a bullfrog atrial cell.Q52475875
Reconstruction of the action potential of ventricular myocardial fibres.Q52812079
Intracellular Na+ activates a K+ channel in mammalian cardiac cellsQ53910978
Macroscopic and unitary properties of physiological ion flux through T-type Ca2+ channels in guinea-pig heart cellsQ54059474
Conductance properties of the Na(+)-activated K+ channel in guinea-pig ventricular cells.Q54081583
Interactions of forskolin and ATP with the cytosolic domains of mammalian adenylyl cyclase.Q54559572
Charybdotoxin Binding in the IKs Pore Demonstrates Two MinK Subunits in Each Channel ComplexQ58482877
Linking a genetic defect to its cellular phenotype in a cardiac arrhythmiaQ59087954
Calmodulin kinase II inhibition protects against structural heart diseaseQ59975125
Comment on "Limit cycle oscillations in pacemaker cells"Q63456453
A novel cardiac potassium channel that is active and conductive at depolarized potentialsQ68016398
Mechanisms underlying early and delayed afterdepolarizations induced by catecholaminesQ68465482
Properties of adenosine-triphosphate-regulated potassium channels in guinea-pig ventricular cellsQ68938083
Regulation of a heart potassium channel by protein kinase A and CQ69839766
Catecholamine-stimulated GTPase cycle. Multiple sites of regulation by beta-adrenergic receptor and Mg2+ studied in reconstituted receptor-Gs vesiclesQ69875809
Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricleQ70558190
Torsade de pointes: the long-short initiating sequence and other clinical features: observations in 32 patientsQ71072125
Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinaseQ72204896
A critical role for transmembrane segment IVS6 of the sodium channel alpha subunit in fast inactivationQ72223457
Further characterization and reconstitution of the purified Ca2+-pumping ATPase of heart sarcolemmaQ72787984
Enhanced Ca(2+) release and Na/Ca exchange activity in hypertrophied canine ventricular myocytes: potential link between contractile adaptation and arrhythmogenesisQ73108727
A plethora of mechanisms in the HERG-related long QT syndrome. Genetics meets electrophysiologyQ73482820
Modeling short-term interval-force relations in cardiac muscleQ73532308
A founder mutation of the potassium channel KCNQ1 in long QT syndrome: implications for estimation of disease prevalence and molecular diagnosticsQ73536405
Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndromeQ73762841
Two distinct congenital arrhythmias evoked by a multidysfunctional Na(+) channelQ73783799
Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytesQ73821726
Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac deathQ73832369
Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction couplingQ73833055
LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transportQ77136323
Ionic mechanism of electrical alternansQ77481025
MinK-KvLQT1 fusion proteins, evidence for multiple stoichiometries of the assembled IsK channelQ77677778
Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation studyQ77726098
Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and IIQ77932855
Genetic and molecular basis of cardiac arrhythmias: impact on clinical management part IIIQ78019850
P433issue1
P921main subjectcardiologyQ10379
computational biologyQ177005
electrophysiologyQ1154774
P304page(s)57-116
P577publication date2006-02-01
P1433published inQuarterly Reviews of BiophysicsQ2361372
P1476titleComputational biology in the study of cardiac ion channels and cell electrophysiology
P478volume39

Reverse relations

cites work (P2860)
Q91858933A Xenopus oocyte model system to study action potentials
Q91669372A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources
Q39125524A computationally efficient algorithm for fitting ion channel parameters.
Q37282277A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells
Q30488360A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential
Q47666024Alternans promotion in cardiac electrophysiology models by delay differential equations
Q31139964An atlas- and data-driven approach to initializing reaction-diffusion systems in computer cardiac electrophysiology.
Q59037496Analytical Study of Fractional-Order Multiple Chaotic FitzHugh-Nagumo Neurons Model Using Multistep Generalized Differential Transform Method
Q34329504Atrial fibrillation and sinus node dysfunction in human ankyrin-B syndrome: a computational analysis
Q58648638Bifurcating Solutions to the Monodomain Model Equipped with FitzHugh-Nagumo Kinetics
Q33157910Biophysical properties of 9 KCNQ1 mutations associated with long-QT syndrome.
Q89436058Bond graph modelling of the cardiac action potential: implications for drift and non-unique steady states
Q38009794Bridging experiments, models and simulations: an integrative approach to validation in computational cardiac electrophysiology
Q26781547Bridging scales through multiscale modeling: a case study on protein kinase A
Q30426852Cardiac models in drug discovery and development: a review
Q44109577Cellular information dynamics through transmembrane flow of ions
Q33345106Chaste: using agile programming techniques to develop computational biology software
Q64115291Combination of "quadratic adaptive algorithm" and "hybrid operator splitting" or uniformization algorithms for stability against acceleration in the Markov model of sodium ion channels in the ventricular cell model
Q47568627Comparing two sequential Monte Carlo samplers for exact and approximate Bayesian inference on biological models.
Q38605343Computational Membrane Biophysics: From Ion Channels Interactions with Drugs to Cellular Function
Q37174582Computational approaches to understand cardiac electrophysiology and arrhythmias
Q27322666Computational model of erratic arrhythmias in a cardiac cell network: the role of gap junctions
Q34020140Computational modelling elucidates the mechanism of ciliary regulation in health and disease.
Q42965487Computational modelling of the initiation and development of spontaneous intracellular Ca2+ waves in ventricular myocytes
Q38638006Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation.
Q96815979Computational translation of drug effects from animal experiments to human ventricular myocytes
Q33677176Contributions of ion channel currents to ventricular action potential changes and induction of early afterdepolarizations during acute hypoxia
Q34132568Defining new insight into atypical arrhythmia: a computational model of ankyrin-B syndrome
Q53828026Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study.
Q28535491Determinants of beat-to-beat variability of repolarization duration in the canine ventricular myocyte: a computational analysis
Q82270954Early afterdepolarisations and ventricular arrhythmias in cardiac tissue: a computational study
Q57187143Effects of β-subunit on gating of a potassium ion channel: Molecular simulations of cardiac IKs activation
Q33425857Functional interactions between KCNE1 C-terminus and the KCNQ1 channel
Q34987142Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias
Q51678236High-throughput cardiac science on the Grid.
Q28601926Hodgkin-Huxley revisited: reparametrization and identifiability analysis of the classic action potential model with approximate Bayesian methods
Q52699573How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels.
Q35683380Human cardiac systems electrophysiology and arrhythmogenesis: iteration of experiment and computation
Q89964079Improved Computational Identification of Drug Response Using Optical Measurements of Human Stem Cell Derived Cardiomyocytes in Microphysiological Systems
Q37706949In silico assessment of drug safety in human heart applied to late sodium current blockers
Q92997724In silico trials: Verification, validation and uncertainty quantification of predictive models used in the regulatory evaluation of biomedical products
Q27332176Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome
Q59794500Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems
Q35021903KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity
Q35632946Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation.
Q34785976Local control of β-adrenergic stimulation: Effects on ventricular myocyte electrophysiology and Ca(2+)-transient
Q34358818Long-chain acylcarnitines regulate the hERG channel
Q42009686LongQt: A cardiac electrophysiology simulation platform
Q45065487Markov models for ion channels: versatility versus identifiability and speed
Q34548564Mathematical model of the neonatal mouse ventricular action potential
Q34089490Mathematical modeling of physiological systems: an essential tool for discovery.
Q47758712Mechanisms and models of cardiac sodium channel inactivation.
Q26779602Modeling Electrophysiological Coupling and Fusion between Human Mesenchymal Stem Cells and Cardiomyocytes
Q51320073Modeling ion channel dynamics through reflected stochastic differential equations.
Q36899903Modeling subunit cooperativity in opening of tetrameric ion channels.
Q36948777Multi-scale computational modelling in biology and physiology
Q37279192Parameter sensitivity analysis in electrophysiological models using multivariable regression
Q28550678Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs
Q44505007Potassium channels in the heart: structure, function and regulation.
Q37162572Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium.
Q35456738Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis
Q35850064Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species.
Q28242126Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue
Q39306025Role of Mg(2+) block of the inward rectifier K(+) current in cardiac repolarization reserve: A quantitative simulation.
Q36254025Role of action potential configuration and the contribution of C²⁺a and K⁺ currents to isoprenaline-induced changes in canine ventricular cells
Q41652870Role of activated CaMKII in abnormal calcium homeostasis and I(Na) remodeling after myocardial infarction: insights from mathematical modeling
Q28478313Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
Q50751968Space-discretization error analysis and stabilization schemes for conduction velocity in cardiac electrophysiology.
Q37597517Structural and regulatory evolution of cellular electrophysiological systems
Q30433543Sudden cardiac death prediction and prevention: report from a National Heart, Lung, and Blood Institute and Heart Rhythm Society Workshop
Q34013724Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.
Q62495888The Structural Basis of IKs Ion-Channel Activation: Mechanistic Insights from Molecular Simulations
Q56995733The cardiovascular system: Mathematical modelling, numerical algorithms and clinical applications
Q36342116The virtual heart as a platform for screening drug cardiotoxicity
Q28084180Three-dimensional cardiac computational modelling: methods, features and applications
Q34097632Transmural heterogeneity of repolarization and Ca2+ handling in a model of mouse ventricular tissue
Q37774882Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy
Q38026557Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies.

Search more.