Two open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channels

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Two open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channels is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1469-7793.2001.0135B.X
P8608Fatcat IDrelease_5lt3cqgemrf6np4htnluyspshe
P932PMC publication ID2278592
P698PubMed publication ID11351022
P5875ResearchGate publication ID11986677

P50authorMichael PuschQ38589708
P2093author name stringT Friedrich
L Ferrera
P2860cites workKCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafnessQ22008780
MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmiaQ22009462
A constitutively open potassium channel formed by KCNQ1 and KCNE3Q22011154
Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversityQ22254006
The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and SelectivityQ22337058
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesQ22337395
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmiasQ24311437
KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmiasQ24313536
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channelQ24318271
A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newbornsQ24319094
Voltage-dependent inactivation of the human K+ channel KvLQT1 is eliminated by association with minimal K+ channel (minK) subunitsQ24653858
Negative Conductance Caused by Entry of Sodium and Cesium Ions into the Potassium Channels of Squid AxonsQ24655934
The conduction pore of a cardiac potassium channelQ28262167
Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsyQ28292575
Cloning of a membrane protein that induces a slow voltage-gated potassium currentQ28292630
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium currentQ28295470
The LQT syndromes--current status of molecular mechanismsQ33688444
Evidence for multiple open and inactivated states of the hKv1.5 delayed rectifierQ34168352
Activation and inactivation of homomeric KvLQT1 potassium channels.Q34168644
MinK endows the I(Ks) potassium channel pore with sensitivity to internal tetraethylammoniumQ34173837
Neuronal KCNQ potassium channels: physiology and role in disease.Q34185467
The interaction of Na+ and K+ in voltage-gated potassium channels. Evidence for cation binding sites of different affinityQ36420126
Sodium ions as blocking agents and charge carriers in the potassium channel of the squid giant axonQ36432674
Ionic permeation and blockade in Ca2+-activated K+ channels of bovine chromaffin cellsQ36433498
Relief of Na+ block of Ca2+-activated K+ channels by external cationsQ36433512
Single-channel properties of IKs potassium channelsQ36436185
Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndromeQ36436190
Single streptomyces lividans K(+) channels: functional asymmetries and sidedness of proton activationQ36436261
Interaction between quaternary ammonium ions in the pore of potassium channels. Evidence against an electrostatic repulsion mechanismQ36442915
Selectivity changes during activation of mutant Shaker potassium channelsQ36445050
Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channelsQ40156271
Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmiasQ48045058
Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK.Q50741839
Visual identification of individual transfected cells for electrophysiology using antibody-coated beadsQ72495840
P433issuePt 1
P407language of work or nameEnglishQ1860
P304page(s)135-143
P577publication date2001-05-01
P1433published inJournal of PhysiologyQ7743612
P1476titleTwo open states and rate-limiting gating steps revealed by intracellular Na+ block of human KCNQ1 and KCNQ1/KCNE1 K+ channels
P478volume533

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cites work (P2860)
Q34186985A computational model of the human left-ventricular epicardial myocyte
Q34568142Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis
Q42594497Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel.
Q36015209Computational biology in the study of cardiac ion channels and cell electrophysiology.
Q34634464Computational modeling reveals key contributions of KCNQ and hERG currents to the malleability of uterine action potentials underpinning labor
Q43078277Effect of K+ and Rb+ on the action of verapamil on a voltage-gated K+ channel, hKv1.3: implications for a second open state?
Q36436477Extracellular sodium interacts with the HERG channel at an outer pore site
Q47127280Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening
Q37039299Modification of K+ channel-drug interactions by ancillary subunits.
Q50667198Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels.
Q40268694Na+ permeation and block of hERG potassium channels
Q48820160Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels
Q38690407Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels
Q36856367Voltage-dependent C-type inactivation in a constitutively open K+ channel