Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

scientific article published on March 14, 2013

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMCL.2013.03.013
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0960894X13003296?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0960894X13003296?httpAccept=text/xml
https://doi.org/10.1016/j.bmcl.2013.03.013
https://europepmc.org/articles/PMC3648997
https://europepmc.org/articles/pmc3648997?pdf=render
https://europepmc.org/articles/PMC3648997?pdf=render
P932PMC publication ID3648997
P698PubMed publication ID23562243

P50authorStuart SchreiberQ906562
Longqin HuQ51736154
T.A. LewisQ67474605
Ah-Ng KongQ88994223
P2093author name stringLin Chen
Lili Wang
Yu Chen
Jian Shen
Ah-Ng Tony Kong
Benito Munoz
Sadagopan Magesh
Sivaraman Dandapani
Daigo Inoyama
Carol Khodier
Michelle Palmer
Stuart L. Schreiber
Thomas J. Emge
John E. Kerrigan
Lesa J. Beamer
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Small Molecule Modulators of Keap1‐Nrf2‐ARE Pathway as Potential Preventive and Therapeutic AgentsQ28386244
Discovery of Potent, Novel Nrf2 Inducers Via Quantum Modeling, Virtual Screening, and In Vitro Experimental ValidationQ30559467
Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer.Q33733198
Bardoxolone methyl and kidney function in CKD with type 2 diabetesQ34194954
A novel strategy to activate cytoprotective genes in the injured brainQ34686666
Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, ChinaQ34790043
Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonanceQ35555898
The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stressQ35837805
Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction.Q35842879
Chemical and molecular regulation of enzymes that detoxify carcinogensQ36210195
Nrf2 as a target for cancer chemopreventionQ36212945
Nrf2: a potential molecular target for cancer chemoprevention by natural compoundsQ36399767
Chemopreventive promise of targeting the Nrf2 pathwayQ36794329
Dual roles of Nrf2 in cancerQ37119963
The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative diseaseQ37248671
Targeting the Nrf2 pathway against cardiovascular diseaseQ37521075
The cytoprotective role of the Keap1-Nrf2 pathwayQ37848718
Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.Q39623558
An alkaloid-mediated desymmetrization of meso-anhydrides via a nucleophilic ring opening with benzyl alcohol and its application in the synthesis of highly enantiomerically enriched β-amino acidsQ57404992
Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I StudyQ63433163
Control of oxidative stress by the Keap1-Nrf2 pathwayQ83694391
Effect of Bardoxolone Methyl on Kidney Function in Patients with T2D and Stage 3b–4 CKDQ83917014
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectprotein-protein interactionQ896177
P1104number of pages5
P304page(s)3039-3043
P577publication date2013-03-14
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleDiscovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction
Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction
P478volume23

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cites work (P2860)
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