| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/J.TIPS.2007.07.003 |
| P698 | PubMed publication ID | 17692392 |
| P2093 | author name string | Stephen P Soltoff | |
| P433 | issue | 9 | |
| P304 | page(s) | 453-458 | |
| P577 | publication date | 2007-08-10 | |
| P1433 | published in | Trends in Pharmacological Sciences | Q2451474 |
| P1476 | title | Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta | |
| P478 | volume | 28 |
| Q36183914 | A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors |
| Q53363192 | A key role for gp130 expressed on peripheral sensory nerves in pathological pain. |
| Q90638381 | Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways |
| Q33881442 | Activation of protein kinase C isoforms and its impact on diabetic complications |
| Q37459860 | Activation of the TRPV4 ion channel is enhanced by phosphorylation. |
| Q40023913 | Aldosterone regulates rapid trafficking of epithelial sodium channel subunits in renal cortical collecting duct cells via protein kinase D activation. |
| Q39210293 | Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy. |
| Q35958584 | BKCa channel activation increases cardiac contractile recovery following hypothermic ischemia/reperfusion |
| Q28478397 | Biosynthesis of promatrix metalloproteinase-9/chondroitin sulphate proteoglycan heteromer involves a Rottlerin-sensitive pathway |
| Q97421354 | CagA orchestrates eEF1A1 and PKCδ to induce interleukin-6 expression in Helicobacter pylori-infected gastric epithelial cells |
| Q30393891 | Comprehensive Structural and Functional Characterization of the Human Kinome by Protein Structure Modeling and Ligand Virtual Screening |
| Q42255764 | Critical appraisal of the MTT assay in the presence of rottlerin and uncouplers. |
| Q36271232 | Cytoplasmic phospholipase A₂ modulation of adolescent rat ethanol-induced protein kinase C translocation and behavior. |
| Q37523285 | Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method |
| Q45072634 | Diabetic Microvascular Disease: An Endocrine Society Scientific Statement |
| Q33386819 | Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets |
| Q33648567 | Dissecting the factors involved in the locomotion mode of neuronal migration in the developing cerebral cortex |
| Q24598316 | Distinct PTPmu-associated signaling molecules differentially regulate neurite outgrowth on E-, N-, and R-cadherin |
| Q37651042 | Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation. |
| Q35887700 | Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. |
| Q34077759 | Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro |
| Q34559604 | Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta |
| Q37058186 | Enhancement of inhibitory neurotransmission and inhibition of excitatory mechanisms underlie the anticonvulsant effects of Mallotus oppositifolius |
| Q33902921 | Estrogen increases ENaC activity via PKCδ signaling in renal cortical collecting duct cells |
| Q34138135 | First identification of small-molecule inhibitors of Pontin by combining virtual screening and enzymatic assay |
| Q47843852 | Fluorescence labelling of extracellular vesicles using a novel thiol-based strategy for quantitative analysis of cellular delivery and intracellular traffic |
| Q34683308 | Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease |
| Q36559393 | Human Neutrophil Elastase Induce Interleukin-10 Expression in Peripheral Blood Mononuclear Cells through Protein Kinase C Theta/Delta and Phospholipase Pathways |
| Q33531815 | Human cytomegaloviruses expressing yellow fluorescent fusion proteins--characterization and use in antiviral screening |
| Q54314310 | IL-1β-Induced Mesenchymal Stem Cell Migration Involves MLCK Activation via PKC Signaling. |
| Q91827368 | Identification of Targetable Pathways in Oral Cancer Patients via Random Forest and Chemical Informatics |
| Q35640132 | Identification of kinase inhibitors that target transcription initiation by RNA polymerase II |
| Q36954876 | In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation. |
| Q84599923 | Inhibiting the Inhibitor of the Inhibitor: Blocking PKC-θ to Enhance Regulatory T Cell Function |
| Q35572426 | Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer |
| Q54309464 | Inhibition of protein kinase (PK) Cδ attenuates methamphetamine-induced dopaminergic toxicity via upregulation of phosphorylation of tyrosine hydroxylase at Ser40 by modulation of protein phosphatase 2A and PKA. |
| Q33801828 | Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay |
| Q35842003 | Insulin promotes neuronal survival via the alternatively spliced protein kinase CδII isoform. |
| Q36903990 | Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact |
| Q39759467 | Ischemia induces regulator of G protein signaling 2 (RGS2) protein upregulation and enhances apoptosis in astrocytes |
| Q36368230 | Isozyme-specific interaction of protein kinase Cδ with mitochondria dissected using live cell fluorescence imaging. |
| Q43079558 | Kaposi's sarcoma-associated herpesvirus kaposin B induces unique monophosphorylation of STAT3 at serine 727 and MK2-mediated inactivation of the STAT3 transcriptional repressor TRIM28. |
| Q34947739 | Loss of protein kinase C-δ protects against LPS-induced osteolysis owing to an intrinsic defect in osteoclastic bone resorption |
| Q36573922 | Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ. |
| Q37855881 | Low-molecular-weight MK2 inhibitors: a tough nut to crack! |
| Q33942716 | Mallotus philippinensis Muell. Arg (Euphorbiaceae): ethnopharmacology and phytochemistry review |
| Q83235743 | Modulation of p53 by mitogen-activated protein kinase pathways and protein kinase C delta during avian reovirus S1133-induced apoptosis |
| Q38834586 | Multifunctional roles of PKCδ: Opportunities for targeted therapy in human disease |
| Q38899613 | Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway |
| Q43878954 | Non-ATP-competitive kinase inhibitors - enhancing selectivity through new inhibition strategies |
| Q42821471 | Novel Screening Method for Potential Skin-Whitening Compounds by a Luciferase Reporter Assay |
| Q37308263 | Novel role of protein kinase C-delta Tyr 311 phosphorylation in vascular smooth muscle cell hypertrophy by angiotensin II. |
| Q36990167 | Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy. |
| Q35940384 | OX1 orexin/hypocretin receptor activation of phospholipase D. |
| Q24337295 | Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium |
| Q38821323 | Osmolar regulation of endothelin-1 production by the inner medullary collecting duct |
| Q64080450 | PKC and PKN in heart disease |
| Q44981820 | PKC inhibition markedly enhances Ca2+ signaling and phosphatidylserine exposure downstream of protease-activated receptor-1 but not protease-activated receptor-4 in human platelets |
| Q44274021 | PKC isoenzymes in equine platelets and stimulus induced activation |
| Q42905567 | PKC-δ mediates TCDD-induced apoptosis of chondrocyte in ROS-dependent manner |
| Q90164388 | PKCδ Mediates NF-κB Inflammatory Response and Downregulates SIRT1 Expression in Liver Fibrosis |
| Q34414671 | PKCδ and θ possibly mediate FSH-induced mouse oocyte maturation via NOX-ROS-TACE cascade signaling pathway |
| Q37646564 | PKCδ inhibition enhances tyrosine hydroxylase phosphorylation in mice after methamphetamine treatment. |
| Q37138890 | PKCδ mediates paraquat-induced Nox1 expression in dopaminergic neurons |
| Q90642827 | PKCδ promotes fertilization of mouse embryos in early development via the Cdc25B signaling pathway |
| Q44430636 | PKCδ regulates IL-12p40/p70 production by macrophages and dendritic cells, driving a type 1 healer phenotype in cutaneous leishmaniasis |
| Q28477084 | PKCδ sensitizes neuroblastoma cells to L-buthionine-sulfoximine and etoposide inducing reactive oxygen species overproduction and DNA damage |
| Q91812522 | PKCδ stimulates macropinocytosis via activation of SSH1-cofilin pathway |
| Q52597639 | PKCδ-Mediated Nox2 Activation Promotes Fluid-Phase Pinocytosis of Antigens by Immature Dendritic Cells. |
| Q37655955 | PKCδ/midkine pathway drives hypoxia-induced proliferation and differentiation of human lung epithelial cells |
| Q37005250 | Pendrin function and regulation in Xenopus oocytes |
| Q36497577 | Phosphoinositide-dependent kinase-1 and protein kinase Cδ contribute to endothelin-1 constriction and elevated blood pressure in intermittent hypoxia |
| Q42243246 | Phosphorylation of Fli1 at threonine 312 by protein kinase C delta promotes its interaction with p300/CREB-binding protein-associated factor and subsequent acetylation in response to transforming growth factor beta |
| Q28586109 | Phosphorylation of NLRC4 is critical for inflammasome activation |
| Q38846159 | Polyphenol compounds and PKC signaling |
| Q28066192 | Prospects for Creation of Cardioprotective and Antiarrhythmic Drugs Based on Opioid Receptor Agonists |
| Q34214022 | Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation |
| Q38842875 | Protein Kinase C Isoforms Differentially Regulate Hypoxia-Inducible Factor-1α Accumulation in Cancer Cells |
| Q41002895 | Protein kinase C controls activation of the DNA integrity checkpoint. |
| Q53654933 | Protein kinase C delta contributes to increase in EP3 agonist-induced contraction in mesenteric arteries from type 2 diabetic Goto-Kakizaki rats. |
| Q39084131 | Protein kinase C delta mediated cytotoxicity of 6-Hydroxydopamine via sustained extracellular signal-regulated kinase 1/2 activation in PC12 cells |
| Q37695308 | Protein kinase C delta modulates endothelial nitric oxide synthase after cardiac arrest |
| Q33991241 | Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction |
| Q38105600 | Protein kinase C pharmacology: refining the toolbox |
| Q21131217 | Protein kinase C signaling and cell cycle regulation |
| Q42272087 | Protein kinase C δ (PKCδ) splice variants modulate apoptosis pathway in 3T3L1 cells during adipogenesis: identification of PKCδII inhibitor. |
| Q37141320 | Protein kinase C, an elusive therapeutic target? |
| Q39740403 | Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells |
| Q39915494 | Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity |
| Q37676057 | Protein kinase Cdelta regulates endothelial nitric oxide synthase expression via Akt activation and nitric oxide generation |
| Q28475914 | Protein kinase Cdelta stimulates proteasome-dependent degradation of C/EBPalpha during apoptosis induction of leukemic cells |
| Q34726786 | Protein kinase Cδ protects against bile acid apoptosis by suppressing proapoptotic JNK and BIM pathways in human and rat hepatocytes |
| Q54977098 | Protein kinase Cε regulates nuclear translocation of extracellular signal-regulated kinase, which contributes to bradykinin-induced cyclooxygenase-2 expression. |
| Q38037338 | Protein kinase cδ in apoptosis: a brief overview |
| Q91651231 | Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors |
| Q42409145 | Regulation of Thrombin-Induced Lung Endothelial Cell Barrier Disruption by Protein Kinase C Delta |
| Q36055992 | Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2 |
| Q38265625 | Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer |
| Q36019985 | Regulation of the surface expression of α4β2δ GABAA receptors by high efficacy states |
| Q37568716 | Regulatory roles for histone deacetylation in IL-1beta-induced nitric oxide release in pancreatic beta-cells. |
| Q39733356 | Role for protein kinase C delta in the functional activity of human UGT1A6: implications for drug-drug interactions between PKC inhibitors and UGT1A6. |
| Q35671582 | Role for the SRC family kinase Fyn in sphingolipid acquisition by chlamydiae |
| Q54117747 | Role of Protein Kinase C-delta in regulating platelet activation and platelet-leukocyte interaction during sepsis. |
| Q37661270 | Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. |
| Q39871404 | Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis |
| Q38855614 | Role of protein kinase C in cytokine secretion by lung epithelial cells during infection with Paracoccidioides brasiliensis |
| Q34572349 | Rottlerin Inhibits Lonicera japonica-Induced Photokilling in Human Lung Cancer Cells through Cytoskeleton-Related Signaling Cascade. |
| Q27000504 | Rottlerin and cancer: novel evidence and mechanisms |
| Q38023565 | Rottlerin and curcumin: a comparative analysis. |
| Q35667259 | Rottlerin enhances IL-1β-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells |
| Q37382511 | Rottlerin exhibits anti-cancer effect through inactivation of S phase kinase-associated protein 2 in pancreatic cancer cells |
| Q42485777 | Rottlerin exhibits antiangiogenic effects in vitro |
| Q37702621 | Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer |
| Q30514156 | Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts |
| Q37735226 | Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells |
| Q38358616 | Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells |
| Q41928112 | Rottlerin inhibits ROS formation and prevents NFkappaB activation in MCF-7 and HT-29 cells |
| Q36483003 | Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells |
| Q34401367 | Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathway |
| Q93254411 | Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity |
| Q89538013 | Saturated Fatty Acids in Obesity-Associated Inflammation |
| Q28476186 | Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling |
| Q33729192 | Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption. |
| Q37340973 | Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: Application for Myocardial Injury in Vivo |
| Q39673159 | Significance of host cell kinases in herpes simplex virus type 1 egress and lamin-associated protein disassembly from the nuclear lamina |
| Q26751007 | Silica, Silicosis, and Autoimmunity |
| Q30432989 | Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling |
| Q64064585 | Specific targeting of PKCδ suppresses osteoclast differentiation by accelerating proteolysis of membrane-bound macrophage colony-stimulating factor receptor |
| Q43189423 | Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species |
| Q43137845 | Staurosporine-induced collapse of cochlear hair bundles |
| Q33973406 | Structural basis of protein kinase C isoform function |
| Q35210379 | Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors. |
| Q39066768 | Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells |
| Q28066752 | The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms |
| Q64119457 | The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation |
| Q39678716 | The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP. |
| Q34643586 | The osteogenic or adipogenic lineage commitment of human mesenchymal stem cells is determined by protein kinase C delta |
| Q38406458 | The role of intestinal oxalate transport in hyperoxaluria and the formation of kidney stones in animals and man. |
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| Q30557489 | Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties |
| Q39016063 | Ultrasound enhanced PEI-mediated gene delivery through increasing the intracellular calcium level and PKC-δ protein expression |
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