Therapeutic potential for protein kinase C inhibitor in vascular restenosis

scientific article

Therapeutic potential for protein kinase C inhibitor in vascular restenosis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1177/1074248410382106
P932PMC publication ID3527091
P698PubMed publication ID21183728

P50authorDaria Mochly-RosenQ56073232
P2093author name stringWei Zhou
Hong Chai
Jerry Tsao
Richard Qinxue Ding
P2860cites workPhysical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human plateletsQ24300809
Direct Demonstration of Involvement of Protein Kinase Cα in the Ca2+-induced Platelet AggregationQ24300892
PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formationQ24301041
Pharmacological inhibition of epsilon-protein kinase C attenuates cardiac fibrosis and dysfunction in hypertension-induced heart failureQ28276546
Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathwayQ28361224
PKCalpha regulates platelet granule secretion and thrombus formation in miceQ28505136
Role of PKC and TGF-beta receptor in glucose-induced proliferation of smooth muscle cellsQ28572253
Essential role of PKC-zeta in normal and angiotensin II-accelerated neointimal growth after vascular injuryQ28579623
PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretionQ28586641
A small molecule-kinase interaction map for clinical kinase inhibitorsQ29617451
Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylationQ30442189
Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formationQ33371697
Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.Q33944297
Protein kinase C activation and its pharmacological inhibition in vascular diseaseQ34097328
Rottlerin: an inappropriate and ineffective inhibitor of PKCdeltaQ34662000
Endothelial protein kinase C isoform identity and differential activity of PKCzeta in an athero-susceptible region of porcine aortaQ34670556
Vascular restenosis. Basic science and clinical implicationsQ34676789
Inflammation and restenosis in the stent era.Q34993928
Coated stents for the prevention of restenosis: Part I.Q35001575
Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II.Q46580801
Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cellsQ46740822
Mechanical stress-activated PKCdelta regulates smooth muscle cell migrationQ47643239
Protein kinase C isoforms in human aortic smooth muscle cellsQ47994379
Integrin cleavage regulates bidirectional signalling in vascular smooth muscle cellsQ50275288
Protein kinase C-alpha mediates endothelial barrier dysfunction induced by TNF-alpha.Q50511731
Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.Q50647596
The chemotactic and mitogenic responses of vascular smooth muscle cells to insulin-like growth factor-I require the activation of ERK1/2.Q52101085
Protein kinase C delta activated adhesion regulates vascular smooth muscle cell migration.Q53546084
Protein kinase C-alpha regulates proliferation but not apoptosis in rat coronary vascular smooth muscle cellsQ71083580
Correlation between human vascular smooth muscle cell proliferation and protein kinase C alpha-expression: effect of d-alpha-tocopherolQ71847485
Angiotensin II stimulates tyrosine phosphorylation of the focal adhesion-associated protein paxillin in aortic smooth muscle cellsQ72591900
Morphologic characteristics of lesion formation and time course of smooth muscle cell proliferation in a porcine proliferative restenosis modelQ72726591
Protein kinase C-mediated inhibition of vascular smooth muscle cell proliferation: the isoforms that may mediate G1/S inhibitionQ72897832
Down-regulation of protein kinase C inhibits insulin-like growth factor I-induced vascular smooth muscle cell proliferation, migration, and gene expressionQ73025289
Proliferative effect of lipoprotein lipase on human vascular smooth muscle cellsQ73076597
Activation of PKC-epsilon and ERK1/2 participates in shear-induced endothelial MCP-1 expression that is repressed by nitric oxideQ73294016
Restenosis after coronary stent placement and randomization to a 4-week combined antiplatelet or anticoagulant therapy: six-month angiographic follow-up of the Intracoronary Stenting and Antithrombotic Regimen (ISAR) TrialQ73558460
Acute glucose-induced downregulation of PKC-betaII accelerates cultured VSMC proliferationQ74172709
Prospective randomized trial of corticosteroids for the prevention of restenosis after intracoronary stent implantationQ77933845
Acute platelet inhibition with abciximab does not reduce in-stent restenosis (ERASER study). The ERASER InvestigatorsQ78162518
Systemic immunosuppressive therapy with oral Sirolimus after bare metal stent implantation: the missing alternative in the prevention of coronary restenosis after percutaneous coronary interventionsQ79809363
Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allograftsQ80557758
Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulatorsQ81708841
Diabetes and vascular disease: basic concepts of nitric oxide physiology, endothelial dysfunction, oxidative stress and therapeutic possibilitiesQ83963995
Coated stents for the prevention of restenosis: Part II.Q35009006
Protein kinase C-delta regulates migration and proliferation of vascular smooth muscle cells through the extracellular signal-regulated kinase 1/2.Q35691430
In stent restenosis: bane of the stent era.Q35769824
Therapeutic potential of oral antiproliferative agents in the prevention of coronary restenosisQ35917050
Vascular restenosis - striving for therapyQ35925488
Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null miceQ36168899
Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cellsQ36711111
PKC isozymes in chronic cardiac disease: possible therapeutic targets?Q36962140
Approaches for prevention of restenosisQ37039843
Preventing restenosis after angioplasty: a multistage approachQ37056663
Impaired activation of platelets lacking protein kinase C-theta isoformQ37129685
VCAM-1 signals activate endothelial cell protein kinase Calpha via oxidationQ37263935
Protein kinase C[delta] differentially regulates platelet functional responsesQ37344199
Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.Q37651042
Activation of protein kinase Czeta is essential for cytokine-induced metalloproteinase-1, -3, and -9 secretion from rabbit smooth muscle cells and inhibits proliferation.Q38289439
Effects of protein kinase C alpha overexpression on A7r5 smooth muscle cell proliferation and differentiationQ38342165
Calcineurin-NFAT signaling is involved in phenylephrine-induced vascular smooth muscle cell proliferationQ39019415
Activation of PKCbeta(II) and PKCtheta is essential for LDL-induced cell proliferation of human aortic smooth muscle cells via Gi-mediated Erk1/2 activation and Egr-1 upregulation.Q40022023
PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cellsQ40411223
The Src/PLC/PKC/MEK/ERK signaling pathway is involved in aortic smooth muscle cell proliferation induced by glycated LDL.Q40449899
Regulation of expression of the endothelial cell nitric oxide synthaseQ41230965
Spheciosterol sulfates, PKCzeta inhibitors from a philippine sponge Spheciospongia sp.Q41327849
Expression of six protein kinase C isotypes in endothelial cellsQ41502748
Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen.Q41789528
Acute stent thrombosis in a sirolimus eluting stent after wasp sting causing acute myocardial infarction: a case reportQ42152547
The effect of protein kinase C and its alpha subtype on human vascular smooth muscle cell proliferation, migration and fibronectin productionQ42491396
Glucose-induced hyperproliferation of cultured rat aortic smooth muscle cells through polyol pathway hyperactivityQ43611292
Binding specificity for RACK1 resides in the V5 region of beta II protein kinase C.Q43626701
Synergistic effect of urotensin II with mildly oxidized LDL on DNA synthesis in vascular smooth muscle cellsQ43660489
Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferationQ43675828
Identification of protein kinase Calpha as an essential, but not sufficient, cytosolic factor for Ca2+-induced alpha- and dense-core granule secretion in plateletsQ43701621
Synergistic effect of urotensin II with serotonin on vascular smooth muscle cell proliferationQ43810240
Overexpression of protein kinase C alpha and beta1 has distinct effects on bovine aortic endothelial cell growthQ43881127
High glucose abolishes the antiproliferative effect of 17beta-estradiol in human vascular smooth muscle cellsQ43908119
Effects of hypoxia on rat airway smooth muscle cell proliferationQ44355304
Tumor Necrosis Factor-α Induces Early-Onset Endothelial Adhesivity by Protein Kinase Cζ–Dependent Activation of Intercellular Adhesion Molecule-1Q44417182
Selective inhibition of protein kinase Cbeta2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cellsQ44947018
Altered PDGF-BB-induced p38 MAP kinase activation in diabetic vascular smooth muscle cells: roles of protein kinase C-deltaQ45042440
Functional interaction of protein kinase Calpha with the tyrosine kinases Syk and Src in human platelets.Q45176611
Modification of PI3K- and MAPK-dependent chemotaxis in aortic vascular smooth muscle cells by protein kinase CbetaII.Q45182851
Central role of PKCbeta in neointimal expansion triggered by acute arterial injury.Q45232098
PKC-delta-dependent pathways contribute to PDGF-stimulated ERK1/2 activation in vascular smooth muscleQ45241916
Role of Ras/PKCzeta/MEK/ERK1/2 signaling pathway in angiotensin II-induced vascular smooth muscle cell proliferationQ45274653
Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxisQ46277544
P433issue2
P304page(s)160-167
P577publication date2010-12-23
P1433published inJournal of Cardiovascular Pharmacology and TherapeuticsQ1855644
P1476titleTherapeutic potential for protein kinase C inhibitor in vascular restenosis
P478volume16

Reverse relations

cites work (P2860)
Q39045977Antileukemic effects of midostaurin in acute myeloid leukemia - the possible importance of multikinase inhibition in leukemic as well as nonleukemic stromal cells
Q33833050Circulating mircoRNA-21 as a predictor for vascular restenosis after interventional therapy in patients with lower extremity arterial occlusive disease
Q36064282Dexmedetomidine-Induced Contraction in the Isolated Endothelium-Denuded Rat Aorta Involves PKC-δ-mediated JNK Phosphorylation.
Q54321998Dexmedetomidine-induced contraction involves c-Jun NH2 -terminal kinase phosphorylation through activation of the 5-lipoxygenase pathway in the isolated endothelium-denuded rat aorta.
Q49923465Evolving Mechanisms of Vascular Smooth Muscle Contraction Highlight Key Targets in Vascular Disease
Q89841062IRF-1 mediates the suppressive effects of mTOR inhibition on arterial endothelium
Q64108192Mass Spectrometric Imaging Reveals Temporal and Spatial Dynamics of Bioactive Lipids in Arteries Undergoing Restenosis
Q90431751Monoclonal Antibody to Marinobufagenin Downregulates TGFβ Profibrotic Signaling in Left Ventricle and Kidney and Reduces Tissue Remodeling in Salt-Sensitive Hypertension
Q41633518PKCε mediates resistin-induced NADPH oxidase activation and inflammation leading to smooth muscle cell dysfunction and intimal hyperplasia
Q47131231Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders
Q37695308Protein kinase C delta modulates endothelial nitric oxide synthase after cardiac arrest
Q37141320Protein kinase C, an elusive therapeutic target?
Q38001437Restenosis and therapy
Q35559964TNF-α mediates PKCδ/JNK1/2/c-Jun-dependent monocyte adhesion via ICAM-1 induction in human retinal pigment epithelial cells

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