Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms.

scientific article

Phenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.BBCAN.2014.08.003
P932PMC publication ID4260992
P698PubMed publication ID25152445
P5875ResearchGate publication ID265018565

P50authorKim Sung-hoonQ13452316
P2093author name stringSanjay K Srivastava
Stephen E Wright
Parul Gupta
P2860cites workThe Hallmarks of CancerQ221226
Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cellsQ21261317
Hallmarks of Cancer: The Next GenerationQ22252312
Reactive oxygen species: role in the development of cancer and various chronic conditionsQ24548312
Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basisQ24641921
Modulation of human serum glutathione S-transferase A1/2 concentration by cruciferous vegetables in a controlled feeding study is influenced by GSTM1 and GSTT1 genotypesQ24656071
Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemopreventionQ24657569
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
Inhibition and inactivation of human cytochrome P450 isoforms by phenethyl isothiocyanateQ28206507
Cruciferous vegetables and cancer preventionQ28208356
Induction of lung lesions in Wistar rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by aspirin and phenethyl isothiocyanateQ28211715
In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot studyQ28285194
Molecular targets of isothiocyanates in cancer: recent advancesQ28307527
Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathwaysQ28308253
Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanateQ28384383
Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cellsQ28396209
Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cellsQ28397373
Phenethylisothiocyanate alters site- and promoter-specific histone tail modifications in cancer cellsQ28533351
Modulation of rat hepatic and kidney phase II enzymes by cabbage juices: comparison with the effects of indole-3-carbinol and phenethyl isothiocyanateQ28570306
Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanatesQ74048033
Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activityQ74150828
Stage and organ dependent effects of 1-O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8-10-dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis modelQ74646610
Cruciferous vegetables, mushrooms, and gastrointestinal cancer risks in a multicenter, hospital-based case-control study in JapanQ75201279
Urinary total isothiocyanate (ITC) in a population-based sample of middle-aged and older Chinese in Singapore: relationship with dietary total ITC and glutathione S-transferase M1/T1/P1 genotypesQ77347899
Diet, reproductive factors and lung cancer risk among Chinese women in Singapore: evidence for a protective effect of soy in nonsmokersQ77441072
Human metabolism and excretion of cancer chemoprotective glucosinolates and isothiocyanates of cruciferous vegetablesQ77725490
Phenethyl isothiocyanate inhibits angiogenesis in vitro and ex vivoQ79856335
Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotypeQ80007759
Evaluation of the effect of dietary vegetable consumption on reducing risk of transitional cell carcinoma of the urinary bladder in Scottish TerriersQ80363889
Increase in cruciferous vegetable intake in women previously treated for breast cancer participating in a dietary intervention trialQ80364228
Interactions among GSTM1, GSTT1 and GSTP1 polymorphisms, cruciferous vegetable intake and breast cancer riskQ80785310
Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer riskQ80836620
Phenylethyl isothiocyanate and its N-acetylcysteine conjugate suppress the metastasis of SK-Hep1 human hepatoma cellsQ82965990
Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2Q84165659
Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicityQ85060097
β-phenylethyl isothiocyanate reverses platinum resistance by a GSH-dependent mechanism in cancer cells with epithelial-mesenchymal transition phenotypeQ85634545
Differential hepatic GSTA2 expression of arylalkyl isothiocyanates in vivo and in vitro: the molecular mechanism of gene induction by phenethyl isothiocyanateQ85851358
Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Comparison with induction by phenobarbital and 3-methylcholanthreneQ68307928
Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1Q71170301
Effect of oltipraz, alpha-tocopherol, beta-carotene and phenethylisothiocyanate on rat oesophageal, gastric, colonic and hepatic glutathione, glutathione S-transferase and peroxidaseQ71254831
The effects of phenethyl isothiocyanate on benzo[a]pyrene-induced tumors and DNA adducts in A/J mouse lungQ72910616
Dietary intake of isothiocyanates: evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer riskQ73112344
Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanoneQ73648304
Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compoundQ36771195
Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosisQ36808478
In vitro and in vivo effects of phenethyl isothiocyanate treatment on vimentin protein expression in cancer cellsQ36899363
Cruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysisQ36950491
Chemopreventive and anti-angiogenic effects of dietary phenethyl isothiocyanate in an N-methyl nitrosourea-induced breast cancer animal modelQ36994897
Prevention of cigarette smoke-induced lung tumors in mice by budesonide, phenethyl isothiocyanate, and N-acetylcysteineQ37009685
Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implicationsQ37021194
Postdiagnosis cruciferous vegetable consumption and breast cancer outcomes: a report from the After Breast Cancer Pooling ProjectQ37067390
Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cellsQ37160330
Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implicationsQ37264650
Urinary isothiocyanates; glutathione S-transferase M1, T1, and P1 polymorphisms; and risk of colorectal cancer: the Multiethnic Cohort StudyQ37275405
The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanateQ37300043
PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathwayQ37361876
Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, ChinaQ37376279
Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanatesQ37431990
Combinations of N-Acetyl-S-(N-2-Phenethylthiocarbamoyl)-L-Cysteine and myo-inositol inhibit tobacco carcinogen-induced lung adenocarcinoma in miceQ37487617
Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemopreventionQ37990641
PEITC reverse multi-drug resistance of human gastric cancer SGC7901/DDP cell lineQ39108537
Phenethyl isothiocyanate induces apoptosis of cholangiocarcinoma cells through interruption of glutathione and mitochondrial pathway.Q39109829
Phenethyl isothiocyanate triggers apoptosis in human malignant melanoma A375.S2 cells through reactive oxygen species and the mitochondria-dependent pathways.Q39140452
Phenethyl isothiocyanate suppresses EGF-stimulated SAS human oral squamous carcinoma cell invasion by targeting EGF receptor signalingQ39141458
Phenethyl isothiocyanate inhibits androgen receptor-regulated transcriptional activity in prostate cancer cells through suppressing PCAF.Q39153876
Targeting heat shock proteins by phenethyl isothiocyanate results in cell-cycle arrest and apoptosis of human breast cancer cellsQ39175428
Phenethyl isothiocyanate regulates inflammation through suppression of the TRIF-dependent signaling pathway of Toll-like receptorsQ39186474
Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cellsQ39305534
β-Phenethyl isothiocyanate induces death receptor 5 to induce apoptosis in human oral cancer cells via p38.Q39400925
Transcriptomic alterations in human prostate cancer cell LNCaP tumor xenograft modulated by dietary phenethyl isothiocyanateQ39401093
Diet, nutrition, and cancerQ39501319
Mitogen-activated protein kinase mediates the apoptosis of highly metastatic human non-small cell lung cancer cells induced by isothiocyanatesQ39511845
Effect of β-phenylethyl isothiocyanate from cruciferous vegetables on growth inhibition and apoptosis of cervical cancer cells through the induction of death receptors 4 and 5.Q39518731
Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.Q39528016
Phenethyl isothiocyanate promotes immune responses in normal BALB/c mice, inhibits murine leukemia WEHI-3 cells, and stimulates immunomodulations in vivoQ39533295
Phenethyl isothiocyanate (PEITC) promotes G2/M phase arrest via p53 expression and induces apoptosis through caspase- and mitochondria-dependent signaling pathways in human prostate cancer DU 145 cells.Q39745929
Targeting protein kinase C (PKC) and telomerase by phenethyl isothiocyanate (PEITC) sensitizes PC-3 cells towards chemotherapeutic drug-induced apoptosisQ39747791
Inhibition of hypoxia inducible factor by phenethyl isothiocyanate.Q39859462
Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cellsQ39861400
Phenethyl isothiocyanate induced apoptosis via down regulation of Bcl-2/XIAP and triggering of the mitochondrial pathway in MCF-7 cellsQ39903082
Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expressionQ40101701
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.Q40234453
Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potentialQ40267877
Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein).Q40367004
Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.Q40388657
Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanatesQ40486680
Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines.Q40520795
A prospective study of cruciferous vegetables and prostate cancer.Q40541345
Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrestQ40579395
The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis.Q40598314
Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosisQ40644490
Role of glutathione conjugate efflux in cellular protection against benzo[a]pyrene-7,8-diol-9,10-epoxide-induced DNA damageQ40747755
A glutathione S-transferase inducer from papaya: rapid screening, identification and structure-activity relationship of isothiocyanatesQ40862614
Inhibition of Carcinogenic Effects of Polycyclic Hydrocarbons by Benzyl Isothiocyanate and Related Compounds2Q41225000
Isothiocyanates as substrates for human glutathione transferases: structure-activity studies.Q42122470
Inhibitory effects of benzyl isothiocyanate and benzyl thiocyanate on diethylnitrosamine-induced hepatocarcinogenesis in ratsQ42497970
Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machineryQ42561802
Forward and reverse catalysis and product sequestration by human glutathione S-transferases in the reaction of GSH with dietary aralkyl isothiocyanatesQ42824553
Natural products as sources of new drugs over the 30 years from 1981 to 2010Q29616640
Phenethyl isothiocyanate inhibits hypoxia-induced accumulation of HIF-1α and VEGF expression in human glioma cellsQ30456818
Phenethyl isothiocyanate sensitizes glioma cells to TRAIL-induced apoptosisQ30457366
Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathwayQ30499567
GSTM1, GSTT1, GSTP1, and GSTA1 polymorphisms and urinary isothiocyanate metabolites following broccoli consumption in humansQ33279492
Kinetics of the stability of broccoli (Brassica oleracea Cv. Italica) myrosinase and isothiocyanates in broccoli juice during pressure/temperature treatments.Q33436660
Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal modelQ33560683
Dietary phenethylisothiocyanate attenuates bowel inflammation in miceQ33566354
Isothiocyanate exposure, glutathione S-transferase polymorphisms, and colorectal cancer riskQ33666199
Phenethyl isothiocyanate sensitizes androgen-independent human prostate cancer cells to docetaxel-induced apoptosis in vitro and in vivoQ33724512
Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agentsQ33743679
Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophagesQ33791448
p66Shc is indispensable for phenethyl isothiocyanate-induced apoptosis in human prostate cancer cellsQ33793988
Pharmacokinetics and pharmacodynamics of phenethyl isothiocyanate: implications in breast cancer preventionQ33803972
Modulation of microRNA expression by budesonide, phenethyl isothiocyanate and cigarette smoke in mouse liver and lungQ33829198
Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human osteQ33837132
Breast cancer cell growth inhibition by phenethyl isothiocyanate is associated with down-regulation of oestrogen receptor-alpha36Q33939078
Intake of cruciferous vegetables modifies bladder cancer survivalQ33981670
Identification of potential protein targets of isothiocyanates by proteomicsQ33991759
Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expressionQ34000784
Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combinationQ34094986
Autophagy: cellular and molecular mechanismsQ34103624
Inhibition of carcinogenesis by isothiocyanatesQ34119188
Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (Review)Q34128289
Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationshipsQ34159403
Cruciferous Vegetable Intake and Lung Cancer Risk: A Nested Case-Control Study Matched on Cigarette SmokingQ34185557
Dietary Phenethyl Isothiocyanate Alters Gene Expression in Human Breast Cancer CellsQ34186892
Cruciferous vegetables intake and the risk of colorectal cancer: a meta-analysis of observational studiesQ34315597
Metabolism of isothiocyanates in individuals with positive and null GSTT1 and M1 genotypes after drinking watercress juiceQ34328902
Differential Response of Normal (PrEC) and Cancerous Human Prostate Cells (PC-3) to Phenethyl Isothiocyanate-Mediated Changes in Expression of Antioxidant Defense GenesQ34329930
Epigenetic impact of dietary isothiocyanates in cancer chemopreventionQ34343612
Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer modelsQ34348403
Transcriptional regulation of vascular endothelial growth factor in cancer.Q34398077
Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanateQ43075004
Phenethyl isothiocyanate suppresses nitric oxide production via inhibition of phosphoinositide 3-kinase/Akt-induced IFN-gamma secretion in LPS-activated peritoneal macrophages.Q43129737
Oxygen is the key factor associated with the difference between in vivo and in vitro effects of antioxidantsQ43235053
Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in ratsQ43252960
Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer StudyQ43525663
Modulation of biomarkers by chemopreventive agents in smoke-exposed ratsQ43566245
Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humansQ43607675
Dietary isothiocyanates, glutathione S-transferase -M1, -T1 polymorphisms and lung cancer risk among Chinese women in SingaporeQ43757394
Inhibition of benzo(a)pyrene-induced lung tumorigenesis in A/J mice by dietary N-acetylcysteine conjugates of benzyl and phenethyl isothiocyanates during the postinitiation phase is associated with activation of mitogen-activated protein kinases andQ43848547
Differential expression of glutathione S-transferase isoenzymes in murine small intestine and colonQ43962843
Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lungQ44110044
Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastineQ44211838
Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health StudyQ44266878
Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 ratsQ44381265
Induction of glutathione S-transferase, placental type in T9 glioma cells by dibutyryladenosine 3',5'-cyclic monophosphate and modification of its expression by naturally occurring isothiocyanatesQ44469335
Anti-tumour and anti-oxidant activity of naturally occurring isothiocyanates.Q44515503
Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography–tandem mass spectrometryQ44658811
Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3.Q44941454
Dietary isothiocyanates, GSTM1, GSTT1, NAT2 polymorphisms and bladder cancer riskQ45049461
Effect of organic isothiocyanates on breast cancer resistance protein (ABCG2)-mediated transportQ45222334
Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytesQ45239724
Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress.Q45292463
Modulation of detoxification enzymes by watercress: in vitro and in vivo investigations in human peripheral blood cells.Q45918181
Cruciferous vegetables in relation to renal cell carcinoma.Q45947701
Modulation by phenethyl isothiocyanate and budesonide of molecular and histopathologic alterations induced by environmental cigarette smoke in mice.Q45985329
Absorption of bioactive compounds from steamed broccoli and their effect on plasma glutathione S-transferase activity.Q46020624
[Effect of phenethyl isothiocyanate on expression of genes during differentiation process of mouse embryonic stem cells in vitro].Q46111345
Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomasQ46130181
Budesonide and phenethyl isothiocyanate attenuate DNA damage in bronchoalveolar lavage cells of mice exposed to environmental cigarette smokeQ46201750
Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanateQ46311169
Dietary intake of Cruciferous vegetables, Glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian populationQ46413641
Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China.Q46545564
Pharmacokinetics of dietary phenethyl isothiocyanate in ratsQ46717292
Phenethyl isothiocyanate inhibits growth of human chronic myeloid leukemia K562 cells via reactive oxygen species generation and caspasesQ46899018
The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cellsQ46978062
Interplay between histopathological alterations, cigarette smoke and chemopreventive agents in defining microRNA profiles in mouse lung.Q53294108
Potentiation of benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis in mice by D,L-buthionine-S,R-sulfoximine-mediated tissue glutathione depletion.Q53410656
Disposition and pharmacokinetics of phenethyl isothiocyanate and 6-phenylhexyl isothiocyanate in F344 rats.Q53427481
Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes.Q53429810
Effects of long term dietary phenethyl isothiocyanate on the microsomal metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats.Q53439902
Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate.Q53446638
K-ras mutations in lung tumors from A/J and A/J×TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanateQ53460872
Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents.Q53468347
Structure-activity relationships of arylalkyl isothiocyanates for the inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism and the modulation of xenobiotic-metabolizing enzymes in rats and mice.Q53479971
Quantitation of human uptake of the anticarcinogen phenethyl isothiocyanate after a watercress mealQ53489441
Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.Q53514964
Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk.Q53543721
Modulating testosterone stimulated prostate growth by phenethyl isothiocyanate via Sp1 and androgen receptor down-regulation.Q53559692
Phenethyl Isothiocyanate Inhibited Tumor Migration and Invasion via Suppressing Multiple Signal Transduction Pathways in Human Colon Cancer HT29 CellsQ57017839
Essential role of p53 in phenethyl isothiocyanate-induced apoptosisQ63561121
Epidemiological studies on brassica vegetables and cancer risk.Q34403425
Inhibition of EGFR-AKT axis results in the suppression of ovarian tumors in vitro and in preclinical mouse modelQ34405324
Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolismQ34428592
Effects of watercress consumption on urinary metabolites of nicotine in smokersQ34505594
Fruit and vegetable intake in relation to risk of breast cancer in the Black Women's Health StudyQ34514195
Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cellsQ34520431
Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokersQ34733097
Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.Q34764877
Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel In Vivo Metastasis ModelQ34796819
Cruciferous vegetable consumption and lung cancer risk: a systematic reviewQ34915650
Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungsQ34958166
Are isothiocyanates potential anti-cancer drugs?Q34979394
Phenethyl isothiocyanate induces calcium mobilization and mitochondrial cell death pathway in cholangiocarcinoma KKU-M214 cells.Q35058902
Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myelomaQ35143496
Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα.Q35312332
Bim contributes to phenethyl isothiocyanate-induced apoptosis in breast cancer cellsQ35353981
Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by β-phenethyl isothiocyanate: mechanisms for anti-leukemia activityQ35445099
Phenethyl isothiocyanate suppresses inhibitor of apoptosis family protein expression in prostate cancer cells in culture and in vivoQ35846374
Chemoprevention by isothiocyanates and their underlying molecular signaling mechanismsQ35914378
Proteomic analysis of covalent modifications of tubulins by isothiocyanatesQ36030230
Induction of apoptosis in tumor cells by naturally occurring sulfur-containing compoundsQ36082301
Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell DeathQ36163315
Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivoQ36217167
Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosisQ36218790
Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer culturesQ36226632
Role of dietary iodine and cruciferous vegetables in thyroid cancer: a countrywide case-control study in New CaledoniaQ36393275
Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent.Q36502589
Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatinQ36580055
Tumor regression by phenethyl isothiocyanate involves DDB2.Q36608692
Inhibition of androgen-responsive LNCaP prostate cancer cell tumor xenograft growth by dietary phenethyl isothiocyanate correlates with decreased angiogenesis and inhibition of cell attachmentQ36645457
The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivationQ36717177
Biomarkers of phenethyl isothiocyanate-mediated mammary cancer chemoprevention in a clinically relevant mouse modelQ36727385
Dietary isothiocyanates, glutathione S-transferase M1 (GSTM1), and lung cancer risk in African Americans and Caucasians from Los Angeles County, CaliforniaQ36743996
Differential effects of phenethyl isothiocyanate and D,L-sulforaphane on TLR3 signalingQ36754284
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)405-424
P577publication date2014-08-23
P1433published inBiochimica et Biophysica ActaQ864239
P1476titlePhenethyl isothiocyanate: a comprehensive review of anti-cancer mechanisms
P478volume1846

Reverse relations

cites work (P2860)
Q370598182-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke
Q52618019A Review of Promising Natural Chemopreventive Agents for Head and Neck Cancer.
Q53217247A principal mechanism for the cancer chemopreventive activity of phenethyl isothiocyanate is modulation of carcinogen metabolism.
Q35741652Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation.
Q92571924Alyssin and Iberin in Cruciferous Vegetables Exert Anticancer Activity in HepG2 by Increasing Intracellular Reactive Oxygen Species and Tubulin Depolymerization
Q28068135Antiproliferative Effect of Indole Phytoalexins
Q41660926Dietary Phenethyl Isothiocyanate Protects Mice from Colitis Associated Colon Cancer
Q36576975Dietary components as epigenetic-regulating agents against cancer
Q39025354Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers
Q89167611Differentiating Antiproliferative and Chemopreventive Modes of Activity for Electron-Deficient Aryl Isothiocyanates against Human MCF-7 Cells
Q57163862Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition
Q49565076Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells
Q38572921Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors
Q28829316Identification of cancer chemopreventive isothiocyanates as direct inhibitors of the arylamine N-acetyltransferase-dependent acetylation and bioactivation of aromatic amine carcinogens
Q41612750Identification of deubiquitinase targets of isothiocyanates using SILAC-assisted quantitative mass spectrometry.
Q45814721Impact of Natural Compounds on DNA Methylation Levels of the Tumor Suppressor Gene RASSF1A in Cancer
Q52331716Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy.
Q55387579Melt electrospinning of daunorubicin hydrochloride-loaded poly (ε-caprolactone) fibrous membrane for tumor therapy.
Q36050048MiR-135a and MRP1 play pivotal roles in the selective lethality of phenethyl isothiocyanate to malignant glioma cells
Q89510873Molecular Mechanisms of the Anti-Cancer Effects of Isothiocyanates from Cruciferous Vegetables in Bladder Cancer
Q55039774New aspects of antiproliferative activity of 4-hydroxybenzyl isothiocyanate, a natural H2S-donor.
Q35506493PEITC treatment suppresses myeloid derived tumor suppressor cells to inhibit breast tumor growth
Q64095526Phenethyl Isothiocyanate Exposure Promotes Oxidative Stress and Suppresses Sp1 Transcription Factor in Cancer Stem Cells
Q58691415Phenethyl Isothiocyanate Inhibits In Vivo Growth of Xenograft Tumors of Human Glioblastoma Cells
Q57165448Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF1
Q58084855Phenethyl isothiocyanate activates leptin signaling and decreases food intake
Q35896411ROS Accumulation by PEITC Selectively Kills Ovarian Cancer Cells via UPR-Mediated Apoptosis
Q55503143Reactive oxygen species in haematopoiesis: leukaemic cells take a walk on the wild side.
Q92424179Red blood cell membrane-enveloped O2 self-supplementing biomimetic nanoparticles for tumor imaging-guided enhanced sonodynamic therapy
Q38823095Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy
Q53697878The oxidoreductase p66Shc acts as tumor suppressor in BRAFV600E-transformed cells.
Q91690576Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy
Q88468597Usual Cruciferous Vegetable Consumption and Ovarian Cancer: A Case-Control Study
Q52781548[Advances in Research of Antitumor Mechanisms of Isothiocyanates].
Q93165768β-Phenethyl Isothiocyanate Induces Cell Death in Human Osteosarcoma through Altering Iron Metabolism, Disturbing the Redox Balance, and Activating the MAPK Signaling Pathway

Search more.