Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis

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Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E10-07-0570
P932PMC publication ID3057708
P698PubMed publication ID21248204

P2093author name stringGuendalina Rossi
Patrick Brennwald
P2860cites workThe Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiaeQ24561799
The Rho GTPase Rho3 has a direct role in exocytosis that is distinct from its role in actin polarityQ24647386
Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanismQ27644268
Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeastQ27931218
The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targetingQ27932330
Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular functionQ27932466
The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesiclesQ27932839
Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosisQ27933277
The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4pQ27933359
The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosisQ27934654
The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartmentsQ27935566
Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9Q27935690
Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeastQ27935856
Mlc1p is a light chain for the unconventional myosin Myo2p in Saccharomyces cerevisiaeQ27936373
Analysis of a yeast SNARE complex reveals remarkable similarity to the neuronal SNARE complex and a novel function for the C terminus of the SNAP-25 homolog, Sec9.Q27936879
Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesiclesQ27939177
The molecular motor toolbox for intracellular transportQ28211349
Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1Q28215755
Rabs and their effectors: achieving specificity in membrane trafficQ29619989
A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeastQ29620584
Transport-vesicle targeting: tethers before SNAREsQ33772639
Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4.Q34029364
Calmodulin signaling via the IQ motifQ34120325
Ypt/rab gtpases: regulators of protein traffickingQ34386638
Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70pQ34553174
Rho GTPase regulation of exocytosis in yeast is independent of GTP hydrolysis and polarization of the exocyst complexQ34560143
The yeast kinesin-related protein Smy1p exerts its effects on the class V myosin Myo2p via a physical interactionQ34686464
Vesicle transport: a close collaboration of Rabs and effectorsQ35623425
Myosins: tails (and heads) of functional diversityQ36197820
The Sec15 protein responds to the function of the GTP binding protein, Sec4, to control vesicular traffic in yeastQ36221387
The role of Myo2, a yeast class V myosin, in vesicular transportQ36235470
Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosisQ36320849
Secretory vesicle transport velocity in living cells depends on the myosin-V lever arm lengthQ36324635
The role of the COOH terminus of Sec2p in the transport of post-Golgi vesiclesQ36328209
Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging budQ36380043
The terminal tail region of a yeast myosin-V mediates its attachment to vacuole membranes and sites of polarized growthQ36754969
Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretionQ36914328
Sro7p, a Saccharomyces cerevisiae counterpart of the tumor suppressor l(2)gl protein, is related to myosins in functionQ38334814
Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes.Q39848704
Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stressQ40648776
The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblastsQ42497218
The Saccharomyces cerevisiae SOP1 and SOP2 genes, which act in cation homeostasis, can be functionally substituted by the Drosophila lethal(2)giant larvae tumor suppressor geneQ42687279
Interactions of three domains distinguishing the Ras-related GTP-binding proteins Ypt1 and Sec4.Q54310462
Distinct roles of myosin Va in membrane remodeling and exocytosis of secretory granulesQ82867465
P433issue6
P921main subjectexocytosisQ323426
P304page(s)842-857
P577publication date2011-01-19
P1433published inMolecular Biology of the CellQ2338259
P1476titleYeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis
P478volume22

Reverse relations

cites work (P2860)
Q44036219Apical myosin XI anticipates F-actin during polarized growth of Physcomitrella patens cells.
Q30524660Arabidopsis Myosin XI-K Localizes to the Motile Endomembrane Vesicles Associated with F-actin
Q30550022Bem3, a Cdc42 GTPase-activating protein, traffics to an intracellular compartment and recruits the secretory Rab GTPase Sec4 to endomembranes
Q37490408Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.
Q47991408Frontline Science: Tumor necrosis factor-α stimulation and priming of human neutrophil granule exocytosis
Q24322633Identification and characterization of multiple novel Rab-myosin Va interactions
Q34801730In vitro reconstitution of Rab GTPase-dependent vesicle clustering by the yeast lethal giant larvae/tomosyn homolog, Sro7.
Q45069611Lipid-dependent regulation of exocytosis in S. cerevisiae by OSBP homolog (Osh) 4.
Q38021975Mechanisms of cytokinesis in budding yeast.
Q35621765Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex
Q30528813Myosin Vs organize actin cables in fission yeast
Q41993334Quantitative analysis of membrane trafficking in regulation of Cdc42 polarity
Q89896520The Role of Secretory Pathways in Candida albicans Pathogenesis
Q38819431The Sec1/Munc18 Protein Groove Plays a Conserved Role in Interaction with Sec9p/SNAP-25.
Q88396882The tomosyn homologue, Sro7, is a direct effector of the Rab GTPase, Sec4, in post-Golgi vesicle tethering
Q47263177The ubiquitin-proteasome system functionally links neuronal Tomosyn-1 to dendritic morphology
Q41137742Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.
Q27310147Tracking individual secretory vesicles during exocytosis reveals an ordered and regulated process
Q35102466α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding.

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