The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts

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The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1016176339
P356DOI10.1038/35046094
P698PubMed publication ID11117748

P2093author name stringDoe CQ
Manning L
Peng CY
Albertson R
P2860cites workYeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9Q27935690
Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisionsQ28256961
Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release processQ28273215
Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epitheliaQ30176838
Asymmetric cell division: fly neuroblast meets worm zygoteQ34132774
Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogasterQ34166641
Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitorsQ34477283
The mechanism of Golgi segregation during mitosis is cell type-specificQ36820489
Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblastsQ40913027
Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast divisionQ41714205
Miranda is required for the asymmetric localization of Prospero during mitosis in DrosophilaQ42443134
Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts.Q42480871
A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in DrosophilaQ42486222
The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chainQ42771059
Cooperative regulation of cell polarity and growth by Drosophila tumor suppressorsQ47070295
Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localizationQ47881793
Asymmetry across species.Q52574295
P433issue6812
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
Discs large 1 Dmel_CG1725Q29810201
Lethal (2) giant larvae Dmel_CG2671Q29812403
Partner of inscuteable Dmel_CG5692Q29817050
P304page(s)596-600
P577publication date2000-11-01
P1433published inNatureQ180445
P1476titleThe tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts
P478volume408

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cites work (P2860)
Q61806907A chemical-genetics approach to study the role of atypical Protein Kinase C in
Q39714757A family of snail-related zinc finger proteins regulates two distinct and parallel mechanisms that mediate Drosophila neuroblast asymmetric divisions
Q35096233A lethal giant kinase in cell polarity.
Q30817105A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions
Q24539869A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia
Q44357555A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.
Q48643836Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice
Q34283595Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye.
Q47105968Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division.
Q30493926Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium
Q43214185Analysis of partner of inscuteable (mPins) expression in the developing mouse eye.
Q35221496Anterior-posterior axis specification in Drosophila oocytes: identification of novel bicoid and oskar mRNA localization factors
Q42435659Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions
Q35892112Are genetic determinants of asymmetric stem cell division active in hematopoietic stem cells?
Q28185521Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg
Q34286348Asymmetric cell division during animal development
Q34443636Asymmetric cell division in the Drosophila nervous system
Q34132774Asymmetric cell division: fly neuroblast meets worm zygote
Q37811896Asymmetric cell division: recent developments and their implications for tumour biology
Q34723618Asymmetric division of Drosophila neural progenitors
Q35221182Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
Q37979739Balancing self-renewal and differentiation by asymmetric division: insights from brain tumor suppressors in Drosophila neural stem cells
Q36571746Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells
Q36525471Cell Fate Decision Making through Oriented Cell Division
Q52589032Cell division: Not all are born equal.
Q34453034Cell polarity: no need to reinvent the wheel
Q34183921Cell polarity: squaring the circle
Q42514755Cell-cell adhesion accounts for the different orientation of columnar and hepatocytic cell divisions.
Q36365512Compartmentalization in T-cell signalling: membrane microdomains and polarity orchestrate signalling and morphology.
Q47916394Compromising asymmetric stem cell division in Drosophila central brain: Revisiting the connections with tumorigenesis.
Q35041105Control of cell polarity and mitotic spindle positioning in animal cells
Q38217971Control of neural stem cell self-renewal and differentiation in Drosophila
Q37333588Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module
Q39644191Cortical aPKC kinase activity distinguishes neural stem cells from progenitor cells by ensuring asymmetric segregation of Numb
Q37306478Crosstalk between small GTPases and polarity proteins in cell polarization.
Q42438368Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression
Q24671881Distinct roles of Galphai and Gbeta13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions
Q42445994Distribution of lethal giant larvae (Lgl) protein in the tegument and negative impact of siRNA-based gene silencing on worm surface structure and egg hatching in Schistosoma japonicum
Q37457941Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
Q42436143Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry
Q28589659Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis
Q41865584Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome
Q47071031Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis
Q90103107Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis
Q44693355Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells
Q42485369Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division
Q39750530Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner
Q36324711Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia
Q37333619Drosophila asymmetric division, polarity and cancer
Q35768202Drosophila brain tumor metastases express both neuronal and glial cell type markers
Q35222279Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts
Q35985183Drosophila neural progenitor polarity and asymmetric division
Q36404824Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesis
Q33964840Drosophila neuroblasts as a new model for the study of stem cell self-renewal and tumour formation
Q42454045Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport
Q36161077Drosophila screening model for metastasis: Semaphorin 5c is required for l(2)gl cancer phenotype
Q35635180E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein
Q42724030Embryo emergent: elucidating the cell biology of development. The Santa Cruz Conference on Developmental Biology 2000.
Q38142056Epithelial polarity and spindle orientation: intersecting pathways
Q33980507Establishment of epithelial polarity--GEF who's minding the GAP?
Q37430722Evaluation of Lethal Giant Larvae as a Schistosomiasis Vaccine Candidate.
Q49478610Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours in Drosophila
Q40055182Filament-dependent and -independent localization modes of Drosophila non-muscle myosin II.
Q37173420Frequent unanticipated alleles of lethal giant larvae in Drosophila second chromosome stocks
Q42747736Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis
Q36985648Functional involvement of human discs large tumor suppressor in cytokinesis
Q24672496Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse
Q33576009Genetic mechanisms regulating stem cell self-renewal and differentiation in the central nervous system of Drosophila
Q35794212Genetic screen for regulators of lymph gland homeostasis and hemocyte maturation in Drosophila
Q55446420Genome-wide surveys reveal polarity and cytoskeletal regulators mediate LKB1-associated germline stem cell quiescence.
Q34795822Heads or tails: cell polarity and axis formation in the early Caenorhabditis elegans embryo
Q43124033Heterogeneity of barrier function in the lung reflects diversity in endothelial cell junctions
Q24294765Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis
Q30497964Immature T-cell clustering and efficient differentiation require the polarity protein Scribble
Q34895795Induced paternal effects mimic cytoplasmic incompatibility in Drosophila
Q47072023Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
Q37591350Initial neurogenesis in Drosophila
Q36740046Insights into neural stem cell biology from flies.
Q52602094Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization.
Q30159642Interdomain interactions in the tumor suppressor discs large regulate binding to the synaptic protein GukHolder
Q30157338Intramolecular interactions between the SRC homology 3 and guanylate kinase domains of discs large regulate its function in asymmetric cell division
Q38770014Intrinsic regulation of enteroendocrine fate by Numb.
Q34585567Junctions as organizing centers in epithelial cells? A fly perspective
Q28205051Lano, a novel LAP protein directly connected to MAGUK proteins in epithelial cells
Q38387100Lethal (2) giant larvae: an indispensable regulator of cell polarity and cancer development
Q42440609Lethal Giant Larvae Acts Together with Numb in Notch Inhibition and Cell Fate Specification in the Drosophila Adult Sensory Organ Precursor Lineage
Q36320849Lethal giant larvae proteins interact with the exocyst complex and are involved in polarized exocytosis
Q48765304Lethal(2)giant larvae is required in the follicle cells for formation of the initial AP asymmetry and the oocyte polarity during Drosophila oogenesis
Q37366108Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila
Q60950728Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex
Q52663442Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation.
Q58730941Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis
Q42450348Lgl2 and E-cadherin act antagonistically to regulate hemidesmosome formation during epidermal development in zebrafish
Q27348603Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis
Q64244563Light-Induced Protein Clustering for Optogenetic Interference and Protein Interaction Analysis in S2 Cells
Q24595932Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization
Q33841767Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions.
Q35866519Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis
Q28586326Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice
Q34467761MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex
Q46029130MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.
Q41123065Maintenance of Miranda Localization in Drosophila Neuroblasts Involves Interaction with the Cognate mRNA.
Q28513494Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development
Q33953411Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells
Q37145878Mechanisms of asymmetric cell division: flies and worms pave the way.
Q34280940Membrane targeting and asymmetric localization of Drosophila partner of inscuteable are discrete steps controlled by distinct regions of the protein.
Q38152747Microtubules and actin crosstalk in cell migration and division
Q43157347Miranda cargo-binding domain forms an elongated coiled-coil homodimer in solution: implications for asymmetric cell division in Drosophila
Q47071196Miranda couples oskar mRNA/Staufen complexes to the bicoid mRNA localization pathway
Q47251104Moesin is involved in polarity maintenance and cortical remodelling during asymmetric cell division.
Q39242357Molecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy
Q28188407Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex
Q52095870Myosins motor Miranda.
Q36039396Neural stem cells in Drosophila: molecular genetic mechanisms underlying normal neural proliferation and abnormal brain tumor formation
Q52107545Novel isoforms of Dlg are fundamental for neuronal development in Drosophila.
Q37259869Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells
Q64091210One hundred years of cancer research: no longer in solitude
Q36319259PAR1 specifies ciliated cells in vertebrate ectoderm downstream of aPKC.
Q34348752PDZ proteins and polarity: functions from the fly.
Q30547694PLP inhibits the activity of interphase centrosomes to ensure their proper segregation in stem cells
Q34492529PRIMA1 mutation: a new cause of nocturnal frontal lobe epilepsy
Q24291796Pilt, a novel peripheral membrane protein at tight junctions in epithelial cells
Q89367029Polarity and morphogenesis of the eye epithelium requires the adhesion junction associated adaptor protein Traf4
Q36741582Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation.
Q51905086Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development.
Q30164681Protein 4.1-mediated membrane targeting of human discs large in epithelial cells
Q37111119Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions.
Q96613311Rab11 is essential for lgl mediated JNK-Dpp signaling in dorsal closure and epithelial morphogenesis in Drosophila
Q41769266Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs
Q38901748Regulation of mitotic spindle orientation: an integrated view.
Q36669891Scaffolding proteins at the Drosophila neuromuscular junction
Q30577652Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts
Q30370310Signaling networks during development: the case of asymmetric cell division in the Drosophila nervous system.
Q47072116Signaling through Gs alpha is required for the growth and function of neuromuscular synapses in Drosophila.
Q34934273Small GTPases take the stage
Q36785224Spatial regulation of exocytosis and cell polarity: yeast as a model for animal cells
Q42476158Spatially defined Dsh–Lgl interaction contributes to directional tissue morphogenesis
Q28302977Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells
Q34216354Spindle orientation: what if it goes wrong?
Q36709998Spindle regulation in neural precursors of flies and mammals
Q34285009Stability and function of mammalian lethal giant larvae-1 oncoprotein are regulated by the scaffolding protein RanBPM.
Q35731150Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth
Q48270344Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia
Q49238908Systematic analysis reveals tumor-enhancing and -suppressing microRNAs in Drosophila epithelial tumors.
Q37132817TRAF4, at the Crossroad between Morphogenesis and Cancer
Q83224344Telophase correction refines division orientation in stratified epithelia
Q42437062The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.
Q47703682The PAR proteins: from molecular circuits to dynamic self-stabilizing cell polarity
Q40664929The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.
Q42508762The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila
Q38038640The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.
Q44641754The catalytic domain of xPAK1 is sufficient to induce myosin II dependent in vivo cell fragmentation independently of other apoptotic events
Q26851306The heavy chain has its day: regulation of myosin-II assembly
Q33717074The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts
Q42943491The involvement of lethal giant larvae and Wnt signaling in bottle cell formation in Xenopus embryos
Q33580800The lethal giant larvae gene in Tribolium castaneum: molecular properties and roles in larval and pupal development as revealed by RNA interference
Q24298617The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin
Q35341856The polarity protein Baz forms a platform for the centrosome orientation during asymmetric stem cell division in the Drosophila male germline
Q48134366The precise subcellular localization of Dlg in the Drosophila larva body wall using improved pre-embedding immuno-EM.
Q34718436The proliferation of Drosophila in cancer research: a system for the functional characterization of tumor suppressors and oncogenes
Q30427219The tumor suppressor Lgl1 regulates NMII-A cellular distribution and focal adhesion morphology to optimize cell migration
Q41292969The tumor suppressor Lgl1 regulates front-rear polarity of migrating cells
Q38444916The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements
Q27933359The yeast lgl family member Sro7p is an effector of the secretory Rab GTPase Sec4p
Q27937939The yeast tumor suppressor homologue Sro7p is required for targeting of the sodium pumping ATPase to the cell surface.
Q30497313TheC. eleganshomolog ofDrosophilaLethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo
Q33692936Tumor Suppressor RARRES1 Regulates DLG2, PP2A, VCP, EB1, and Ankrd26.
Q36063647Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex
Q38537596Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease
Q37046640Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth
Q41785743Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis
Q37333623Upsides and downsides to polarity and asymmetric cell division in leukemia.
Q33375197Varicose: a MAGUK required for the maturation and function of Drosophila septate junctions
Q50323081Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II.
Q33959941When fate follows age: unequal centrosomes in asymmetric cell division
Q30553119Wounded cells drive rapid epidermal repair in the early Drosophila embryo
Q34675258Yeast homologues of lethal giant larvae and type V myosin cooperate in the regulation of Rab-dependent vesicle clustering and polarized exocytosis
Q40648776Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stress
Q42480541Zebrafish penner/lethal giant larvae 2 functions in hemidesmosome formation, maintenance of cellular morphology and growth regulation in the developing basal epidermis
Q27316263aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis
Q48175937aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts
Q48182995miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila.
Q43981047nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina
Q36118850p32 is a novel mammalian Lgl binding protein that enhances the activity of protein kinase Czeta and regulates cell polarity

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