Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia

scientific article published on 15 June 2017

Synergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1242/DEV.148171
P698PubMed publication ID28619817

P50authorAna CarmenaQ89634253
P2093author name stringMaribel Franco
Ana de Torres-Jurado
Noemí Rives-Quinto
P2860cites workThe Hallmarks of CancerQ221226
Hallmarks of Cancer: The Next GenerationQ22252312
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinomaQ24319145
The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interactionQ24338616
Regulation of myeloid leukaemia by the cell-fate determinant MusashiQ24634359
Distinct roles of Galphai and Gbeta13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisionsQ24671881
The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domainQ24683045
Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermisQ27348603
Fiji: an open-source platform for biological-image analysisQ27860912
Junctional recruitment of mammalian Scribble relies on E-cadherin engagementQ28243180
Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisionsQ28256961
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenesQ28265486
The diverse functions of microRNAs in animal development and diseaseQ28266193
Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signallingQ28287899
Asymmetric cell division of stem and progenitor cells during homeostasis and cancerQ28292920
The ImageJ ecosystem: An open platform for biomedical image analysisQ28364366
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cellsQ28646359
Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain developmentQ30481439
Imaging hematopoietic precursor division in real timeQ30481466
Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cellsQ30492732
The PDZ protein Canoe/AF-6 links Ras-MAPK, Notch and Wingless/Wnt signaling pathways by directly interacting with Ras, Notch and DishevelledQ33267326
Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancerQ33896844
Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastomaQ34052754
MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genesQ34222706
Identification of AF-6 and canoe as putative targets for Ras.Q34371134
Neural stem cells: balancing self-renewal with differentiationQ34763775
Combined deletion of Pten and p53 in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2KQ34880928
Analyzing the function of tumor suppressor genes using a Drosophila modelQ35141497
The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientationQ35670607
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wingQ35787233
Asymmetry-defective oligodendrocyte progenitors are glioma precursorsQ35814886
Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblastsQ36293793
Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastomaQ36509996
canoe encodes a novel protein containing a GLGF/DHR motif and functions with Notch and scabrous in common developmental pathways in DrosophilaQ36698031
Mechanisms of asymmetric stem cell divisionQ37092865
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in DrosophilaQ37367551
The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.Q38038640
Cell competition, apoptosis and tumour developmentQ38587691
Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expressionQ38870713
MLL-AF6 fusion oncogene sequesters AF6 into the nucleus to trigger RAS activation in myeloid leukemiaQ39008746
MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cellsQ39021636
Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth.Q39561464
Malignant Neoplasms of Genetic Origin in Drosophila melanogasterQ39603384
Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblastsQ40913027
The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in DrosophilaQ41717902
Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetryQ42436143
Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts.Q42480871
Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblastQ42497214
The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblastsQ42497218
DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in DrosophilaQ42498170
Cooperative regulation of cell polarity and growth by Drosophila tumor suppressorsQ47070295
Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.Q47071360
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogasterQ47072023
Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model.Q47072687
The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila.Q47072815
The Drosophila ras oncogenes: structure and nucleotide sequence.Q48389250
Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.Q51224744
Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila.Q52668701
The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors.Q52691731
The hippo pathway core cassette regulates asymmetric cell division.Q52839049
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.Q53370119
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectneural stem cellQ2944097
P1104number of pages14
P304page(s)2570-2583
P577publication date2017-06-15
P1433published inDevelopmentQ3025404
P1476titleSynergism between canoe and scribble mutations causes tumor-like overgrowth via Ras activation in neural stem cells and epithelia
P478volume144

Reverse relations

cites work (P2860)
Q57459857A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer
Q47916394Compromising asymmetric stem cell division in Drosophila central brain: Revisiting the connections with tumorigenesis.
Q90103107Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis
Q91942694Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells
Q49478610Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours in Drosophila
Q52310247Modelling Cooperative Tumorigenesis in Drosophila.

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