Molecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy

scientific article published on January 2017

Molecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/978-3-319-53150-2_18
P8608Fatcat IDrelease_r6hjvp7gangnpetvrq56b456mu
P698PubMed publication ID28409315

P2093author name stringDaniel J Brat
Subhas Mukherjee
P2860cites workWnt signals and frizzled activity orient anterior-posterior axon outgrowth in C. elegansQ82728948
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42Q22254751
Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retinaQ24299778
Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell PolarityQ24300954
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteinsQ24313402
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complexQ24337717
The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitorsQ24569665
Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localizationQ24595932
Regulation of myeloid leukaemia by the cell-fate determinant MusashiQ24634359
Cancer stem cell division: when the rules of asymmetry are brokenQ26851679
Molecular mechanisms of epithelial-mesenchymal transitionQ27013743
Metabolic maintenance of cell asymmetry following division in activated T lymphocytesQ27314597
Oncomirs - microRNAs with a role in cancerQ27860773
Radial glial identity is promoted by Notch1 signaling in the murine forebrainQ28145728
Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignanciesQ28188807
Germline stem cells anchored by adherens junctions in the Drosophila ovary nichesQ28203153
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phasesQ28236938
NUMB controls p53 tumour suppressor activityQ28263413
Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovaryQ28274199
Asymmetric cell division of stem and progenitor cells during homeostasis and cancerQ28292920
Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cellsQ28589354
Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epitheliaQ30176838
Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisionsQ30429671
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancersQ30434796
A role for the TGFbeta-Par6 polarity pathway in breast cancer progressionQ30489618
Coordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38α/β MAPKQ30582181
Aurora B expression directly correlates with prostate cancer malignancy and influence prostate cell proliferationQ33226511
Altered regulation of Prox1-gene-expression in liver tumorsQ33327426
Loss of heterozygosity of TRIM3 in malignant gliomasQ33413437
Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cellsQ33500854
MYC oncogenes and human neoplastic diseaseQ33667340
A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions.Q33751351
Prox1 regulates the notch1-mediated inhibition of neurogenesisQ33784912
Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.Q33920769
c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent pointsQ33958488
Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastomaQ34052754
The cerebrospinal fluid provides a proliferative niche for neural progenitor cellsQ34169014
Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesisQ34304333
The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblastsQ34519483
Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zoneQ35011868
Drosophila Brain Tumor is a translational repressorQ35077727
Stem-cell hierarchy in skin cancerQ35141774
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblastsQ35221182
Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signalingQ35226321
A niche for adult neural stem cellsQ35556003
Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?Q35968417
Evidence of asymmetric cell division and centrosome inheritance in human neuroblastoma cellsQ36398031
Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesisQ36404824
Pathogenetic mechanisms in thyroid follicular-cell neoplasiaQ36430189
Male and female Drosophila germline stem cells: two versions of immortality.Q36796598
Asymmetry of stem cell fate and the potential impact of the niche: observations, simulations, and interpretationsQ36877528
The abbreviated pluripotent cell cycle.Q36886887
Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear TransportQ36918095
Cell polarity in development and cancer.Q36925556
Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesisQ37082090
Mechanisms of asymmetric stem cell divisionQ37092865
Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortexQ37330087
Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activityQ37398471
A localized Wnt signal orients asymmetric stem cell division in vitroQ37664730
Notch Signaling in the Regulation of Stem Cell Self-Renewal and DifferentiationQ37785203
Asymmetric cell division: recent developments and their implications for tumour biologyQ37811896
The relevance of symmetric and asymmetric cell divisions to human central nervous system diseasesQ37834774
MicroRNA biogenesis and regulation of bone remodelingQ37884118
Myc in stem cell behaviour: insights from DrosophilaQ38108585
Metastatic ability of Drosophila tumors depends on MMP activityQ38305585
Notch post-translationally regulates β-catenin protein in stem and progenitor cellsQ38635489
TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.).Q39210791
Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cellsQ39686834
Trans-synaptic transmission of vesicular Wnt signals through Evi/WntlessQ39753324
Loss of function of the candidate tumor suppressor prox1 by RNA mutation in human cancer cellsQ40184230
Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cellsQ40570664
Proteomic analysis of hematopoietic stem cell-like fractions in leukemic disordersQ40639543
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.Q40664929
Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblastsQ40913027
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.Q41073451
The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in DrosophilaQ41717902
Asymmetric inheritance of mother versus daughter centrosome in stem cell divisionQ41956545
Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae.Q42473975
Oblique radial glial divisions in the developing mouse neocortex induce self-renewing progenitors outside the germinal zone that resemble primate outer subventricular zone progenitors.Q42485045
Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblastQ42497214
The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblastsQ42497218
Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis.Q42522587
Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastomaQ46158804
Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase-promoting complex/cyclosome.Q47070227
Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblastsQ47070895
Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.Q47071360
Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewalQ47071774
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogasterQ47072023
Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cellsQ47401361
Mutations in the beta-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brainQ47836373
Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancerQ48212974
Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout miceQ48643836
An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells.Q50789703
Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche.Q51826206
The Drosophila ovarian and testis stem cell niches: similar somatic stem cells and signals.Q51838788
Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.Q52547859
Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation.Q52663442
Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila.Q52713517
The Mutation Theory From the Standpoint of CytologyQ80992520
P304page(s)401-421
P577publication date2017-01-01
P1433published inResults and problems in cell differentiationQ26842363
P1476titleMolecular Programs Underlying Asymmetric Stem Cell Division and Their Disruption in Malignancy
P478volume61

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cites work (P2860)
Q55010335CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells.
Q98773460Orderly assembly underpinning built-in asymmetry in the yeast centrosome duplication cycle requires cyclin-dependent kinase