Neural stem cells in Drosophila: molecular genetic mechanisms underlying normal neural proliferation and abnormal brain tumor formation

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Neural stem cells in Drosophila: molecular genetic mechanisms underlying normal neural proliferation and abnormal brain tumor formation is …
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scholarly articleQ13442814

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P356DOI10.1155/2012/486169
P932PMC publication ID3377361
P698PubMed publication ID22737173
P5875ResearchGate publication ID228071980

P2093author name stringHeinrich Reichert
Nidhi Saini
P2860cites workThe pattern of proliferation of the neuroblasts in the wild-type embryo of Drosophila melanogasterQ89560986
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Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisionsQ28256961
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Asymmetric cell divisions promote stratification and differentiation of mammalian skinQ29620393
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Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system.Q33885616
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Notch regulates the switch from symmetric to asymmetric neural stem cell division in the Drosophila optic lobeQ34080619
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The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblastsQ34519483
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The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell divisionQ34532924
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Concomitant requirement for Notch and Jak/Stat signaling during neuro-epithelial differentiation in the Drosophila optic lobeQ36552024
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Regulating the balance between symmetric and asymmetric stem cell division in the developing brainQ37866606
Neural stem cell biology in vertebrates and invertebrates: more alike than different?Q37879275
The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elementsQ38444916
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Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity.Q40287718
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Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblastsQ40913027
Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepitheliaQ41268202
The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in DrosophilaQ41717902
aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division.Q42157298
Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions.Q42442212
Apical/basal spindle orientation is required for neuroblast homeostasis and neuronal differentiation in Drosophila.Q42457210
Differential functions of G protein and Baz-aPKC signaling pathways in Drosophila neuroblast asymmetric division.Q42457548
miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis.Q42461059
Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts.Q42480871
A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in DrosophilaQ42486222
Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblastQ42497214
The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblastsQ42497218
DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in DrosophilaQ42498170
Patterns of cell division and expression of asymmetric cell fate determinants in postembryonic neuroblast lineages of Drosophila.Q42498611
Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells.Q42509178
Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous systemQ42511782
Role of inscuteable in orienting asymmetric cell divisions in DrosophilaQ42522271
Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6.Q42579481
Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.Q42733015
Proliferation pattern of postembryonic neuroblasts in the brain of Drosophila melanogasterQ45300018
The embryonic development of the Drosophila visual systemQ46181274
Asymmetric segregation of Numb and Prospero during cell divisionQ46547833
Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.Q47071360
Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewalQ47071774
Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in DrosophilaQ47071916
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogasterQ47072023
Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT.Q47072231
inscuteable, a neural precursor gene of Drosophila, encodes a candidate for a cytoskeleton adaptor proteinQ47072391
The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila.Q47072815
Molecular markers for identified neuroblasts in the developing brain of DrosophilaQ47791465
Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localizationQ47881793
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectDrosophilaQ312154
neural stem cellQ2944097
brain tumorQ233309
P304page(s)486169
P577publication date2012-06-07
P1433published inStem Cells InternationalQ26842114
P1476titleNeural stem cells in Drosophila: molecular genetic mechanisms underlying normal neural proliferation and abnormal brain tumor formation
P478volume2012

Reverse relations

cites work (P2860)
Q43814873A multipotent transit-amplifying neuroblast lineage in the central brain gives rise to optic lobe glial cells in Drosophila
Q34723950ASYMMETRIC CELL DIVISION: IMPLICATIONS FOR GLIOMA DEVELOPMENT AND TREATMENT.
Q36266346EAG2 potassium channel with evolutionarily conserved function as a brain tumor target
Q49478610Failure of the PTEN/aPKC/Lgl Axis Primes Formation of Adult Brain Tumours in Drosophila
Q36741582Prefoldin and Pins synergistically regulate asymmetric division and suppress dedifferentiation.
Q39300461The GAL4 System: A Versatile System for the Manipulation and Analysis of Gene Expression.
Q42261731Zinc finger X-chromosomal protein promotes growth and tumorigenesis in human osteosarcoma cells

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