Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer

scientific article published on December 2009

Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GAD.1850809
P932PMC publication ID2788323
P698PubMed publication ID19952104
P5875ResearchGate publication ID40045190

P50authorJürgen KnoblichQ1717362
P2093author name stringRalph A Neumüller
P2860cites workDelta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and functionQ22011016
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42Q22254751
The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1Q24290129
Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell divisionQ47068743
Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domainsQ47068816
Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegansQ47069165
MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryosQ47069199
Depletion of the co-chaperone CDC-37 reveals two modes of PAR-6 cortical association in C. elegans embryosQ47069512
Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryosQ47069527
Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteinsQ47069999
Neuralized contains a phosphoinositide-binding motif required downstream of ubiquitination for delta endocytosis and notch signalingQ47070148
Live-imaging of single stem cells within their niche reveals that a U3snoRNP component segregates asymmetrically and is required for self-renewal in DrosophilaQ47070256
Sara endosomes and the maintenance of Dpp signaling levels across mitosis.Q47070673
Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblastsQ47070895
Unequal segregation of Neuralized biases Notch activation during asymmetric cell divisionQ47071033
Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryosQ47071223
Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.Q47071360
The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesisQ47071621
Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous systemQ47071636
Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell divisionQ47071685
Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cellsQ47071726
Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewalQ47071774
Quantitative analysis of protein dynamics during asymmetric cell divisionQ47071776
A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain.Q47071911
Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in DrosophilaQ47071916
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogasterQ47072023
Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division.Q47072044
Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT.Q47072231
The tripartite motif family identifies cell compartmentsQ24291183
aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant NumbQ24338740
The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitorsQ24569665
Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localizationQ24595932
Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesisQ24624356
Distinct roles of Galphai and Gbeta13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisionsQ24671881
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesisQ24676117
Numb is an endocytic proteinQ24681102
Prospective identification of tumorigenic breast cancer cellsQ24683474
Asymmetry of early endosome distribution in C. elegans embryosQ27302973
Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotesQ27334980
Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificityQ27766331
Stem cells, cancer, and cancer stem cellsQ27860878
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellQ27861001
A mechanism for asymmetric segregation of age during yeast buddingQ27929801
Identification of a cancer stem cell in human brain tumorsQ28131688
A cell initiating human acute myeloid leukaemia after transplantation into SCID miceQ28131777
A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformationQ28139572
Neurons derived from radial glial cells establish radial units in neocortexQ28202112
The SOCS box: a tale of destruction and degradationQ28205975
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phasesQ28236938
Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisionsQ28256961
NUMB controls p53 tumour suppressor activityQ28263413
Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryosQ28280279
The cell biology of neurogenesisQ28284165
Control of daughter cell fates during asymmetric division: interaction of Numb and NotchQ28286748
Aggresomes: a cellular response to misfolded proteinsQ28292275
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributedQ28301842
Determination of cell division axes in the early embryogenesis of Caenorhabditis elegansQ28302830
Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cellsQ28302977
Crypt stem cells as the cells-of-origin of intestinal cancerQ28304418
Modes of spindle pole body inheritance and segregation of the Bfa1p-Bub2p checkpoint protein complexQ28364029
Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progenyQ47072696
The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila.Q47072815
Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localizationQ47881793
Repression of gene expression in the embryonic germ lineage of C. elegansQ47915934
Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryosQ48561935
Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instabilityQ49037799
Cortical microtubule contacts position the spindle in C. elegans embryosQ50685222
Temporal transcription factors and their targets schedule the end of neural proliferation in DrosophilaQ51956127
Asymmetric T lymphocyte division in the initiation of adaptive immune responses.Q51977375
Developmental biology. The mother of all stem cells?Q51996052
CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryosQ52010283
Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cellsQ52014010
Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosomeQ52100403
The prospero gene specifies cell fates in the drosophila central nervous systemQ52444632
Asymmetric segregation of the homeodomain protein Prospero during Drosophila development.Q52536835
The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in DrosophilaQ52537055
Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS.Q52547102
Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNSQ52562911
Evidence that stem cells reside in the adult Drosophila midgut epitheliumQ52663260
The adult Drosophila posterior midgut is maintained by pluripotent stem cellsQ52663264
Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiationQ52663442
Spindle alignment is achieved without rotation after the first cell cycle in Drosophila embryonic neuroblasts.Q52699000
PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryosQ53495600
Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3.Q53543170
Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteinsQ53568166
CYK-4/GAP provides a localized cue to initiate anteroposterior polarity upon fertilization.Q53608548
AGING INSACCHAROMYCES CEREVISIAEQ57175234
Stem Cells and Cancer: Two Faces of EveQ59243883
Identification of genes required for cytoplasmic localization in early C. elegans embryosQ68273724
Immunochemical approach to characterize advanced glycation end products of the Maillard reaction. Evidence for the presence of a common structureQ70141654
PAR proteins regulate microtubule dynamics at the cell cortex in C. elegansQ73341305
Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and NotchQ77336632
Elimination of damaged proteins during differentiation of embryonic stem cellsQ34650731
Neural stem cells: balancing self-renewal with differentiationQ34763775
Asymmetric mitosis: Unequal segregation of proteins destined for degradationQ34782639
The majority of multipotent epidermal stem cells do not protect their genome by asymmetrical chromosome segregationQ34821613
The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursorsQ34988064
The stem-cell niche theory: lessons from fliesQ35013187
Drosophila Brain Tumor is a translational repressorQ35077727
PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegansQ35078092
inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesisQ35189774
Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division inDrosophilaQ35202580
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblastsQ35221182
Germ plasm: protein degradation in the somaQ35572679
Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobeQ35606421
Cleavage furrow positioningQ35646477
Asymmetric localization and function of cell-fate determinants: a fly's viewQ35690282
Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebratesQ35868625
Cancer stem cells in nervous system tumorsQ35892122
Asymmetric cell division in C. elegans: cortical polarity and spindle positioningQ35912817
Heterotrimeric G proteins: new tricks for an old dog.Q35945442
A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function inC. elegansQ35965179
From stem cell to embryo without centriolesQ35980950
Centrosome movement in the early divisions of Caenorhabditis elegans: a cortical site determining centrosome positionQ36147639
ncl-1 Is Required for the Regulation of Cell Size and Ribosomal RNA Synthesis in Caenorhabditis elegansQ36255131
Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblastsQ36293793
Molecular mechanisms of germline stem cell regulationQ36312198
Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitroQ36320656
Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epitheliaQ36324711
The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cellsQ36328376
Drosophila neuroblast asymmetric divisions: cell cycle regulators, asymmetric protein localization, and tumorigenesisQ36404824
The PAR-aPKC system: lessons in polarityQ36416725
PAR proteins direct asymmetry of the cell cycle regulators Polo-like kinase and Cdc25.Q36491719
The Drosophila ovary: an active stem cell communityQ36697534
The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localizationQ36715211
Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell divisionQ42485369
Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteinsQ42485373
A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in DrosophilaQ42486222
Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblastsQ42488951
The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblastsQ42497218
DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in DrosophilaQ42498170
The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in DrosophilaQ42508762
Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells.Q42509178
Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous systemQ42511782
Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortexQ42521702
Role of inscuteable in orienting asymmetric cell divisions in DrosophilaQ42522271
Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis.Q42522587
Asymmetric localization of the adaptor protein Miranda in neuroblasts is achieved by diffusion and sequential interaction of Myosin II and VI.Q42526538
Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signallingQ42805914
Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organsQ43205606
Protein oxidation in G0 cells of Saccharomyces cerevisiae depends on the state rather than rate of respiration and is enhanced in pos9 but not yap1 mutantsQ43657444
The Caenorhabditis elegans par-5 Gene Encodes a 14-3-3 Protein Required for Cellular Asymmetry in the Early EmbryoQ43849657
numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryosQ44665387
Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cellsQ44693355
RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegansQ45103218
MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation.Q45211998
Proliferation pattern of postembryonic neuroblasts in the brain of Drosophila melanogasterQ45300018
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repairQ46210604
Asymmetric segregation of Numb and Prospero during cell divisionQ46547833
Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitorsQ28506397
Drosophila Neuralized Is a Ubiquitin Ligase that Promotes the Internalization and Degradation of DeltaQ28646245
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cellsQ28646359
Mutation selection and the natural history of cancerQ29614279
Defining the epithelial stem cell niche in skinQ29614985
A mechanism linking extra centrosomes to chromosomal instabilityQ29617923
Extrachromosomal rDNA circles--a cause of aging in yeastQ29618308
Asymmetric cell divisions promote stratification and differentiation of mammalian skinQ29620393
Stem cells and niches: mechanisms that promote stem cell maintenance throughout lifeQ29620450
Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryoQ30442050
Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint controlQ30476312
Stabilization of cell polarity by the C. elegans RING protein PAR-2.Q30478491
Microtubules are involved in anterior-posterior axis formation in C. elegans embryosQ30480579
Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain developmentQ30481439
Imaging hematopoietic precursor division in real timeQ30481466
Cytokinesis of neuroepithelial cells can divide their basal process before anaphaseQ30485002
Adherens junction domains are split by asymmetric division of embryonic neural stem cellsQ30487576
Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cellsQ30492732
Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryoQ30654911
The distribution of active force generators controls mitotic spindle positionQ31150806
Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineageQ31157923
Centrosome-dependent exit of cytokinesis in animal cellsQ32062097
High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progenyQ33282298
Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAiQ33429561
Cell polarity in yeastQ33804326
Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions.Q33841767
Rotation and asymmetry of the mitotic spindle direct asymmetric cell division in the developing central nervous system.Q33885616
Molecular cloning of lethal(2)giant larvae, a recessive oncogene of Drosophila melanogasterQ33931438
Asymmetric inheritance of radial glial fibers by cortical neuronsQ34092179
Stem cells find their nicheQ34100153
MEN and SIN: what's the difference?Q34102523
The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in DrosophilaQ34145953
Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogasterQ34166641
Asymmetric inheritance of oxidatively damaged proteins during cytokinesisQ34180285
PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progressionQ34183985
Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryosQ34197454
Life span of individual yeast cellsQ34246486
Receptor-independent activators of heterotrimeric G-proteins.Q34254306
The segregation of DNA in epithelial stem cellsQ34283817
Cleavage orientation and the asymmetric inheritance of notchl immunoreactivity in mammalian neurogenesisQ34304333
RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryosQ34358248
Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity.Q34360639
Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancerQ34398455
Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors.Q34447801
Centriolin anchoring of exocyst and SNARE complexes at the midbody is required for secretory-vesicle-mediated abscissionQ34457967
Partner of Numb Colocalizes with Numb during Mitosis and Directs Numb Asymmetric Localization in Drosophila Neural and Muscle ProgenitorsQ34477283
Model Organisms as a Guide to Mammalian AgingQ34487795
The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetryQ34507504
Centrosome inheritance: birthright or the privilege of maturity?Q34511134
Protein degradation: four E3s for the notch pathwayQ34511141
The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblastsQ34519483
Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organizationQ34519492
The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell divisionQ34532924
Flies without centriolesQ34543650
Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cellsQ34586479
Genetic studies of mei-P26 reveal a link between the processes that control germ cell proliferation in both sexes and those that control meiotic exchange in DrosophilaQ34610042
Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon.Q34618385
Hassles with taking out the garbage: aggravating aggresomes.Q34637179
The immortal strand hypothesis: segregation and reconstruction.Q34644479
Immortal strands? Give me a breakQ34644490
Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the questionQ36749996
Male and female Drosophila germline stem cells: two versions of immortality.Q36796598
Asymmetric cell divisions of human hematopoietic stem and progenitor cells meet endosomesQ36900054
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU.Q37079677
Mechanisms of asymmetric stem cell divisionQ37092865
Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions.Q37111119
Centrosome amplification can initiate tumorigenesis in flies.Q37123357
Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusionQ37124367
Mechanisms of asymmetric cell division: flies and worms pave the way.Q37145878
nhl-2 Modulates microRNA activity in Caenorhabditis elegansQ37161408
Kinetochore asymmetry defines a single yeast lineageQ37167774
Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortexQ37330087
Modeling stem cell asymmetry in yeast.Q37330969
Pten haploinsufficiency accelerates formation of high-grade astrocytomasQ37384874
Asymmetric cell divisions: a view from plant development.Q37521277
Plant asymmetric cell division, vive la différence!Q37535067
Endocytosis, asymmetric cell division, stem cells and cancer: unus pro omnibus, omnes pro unoQ37542578
Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryoQ38353471
Malignant Neoplasms of Genetic Origin in Drosophila melanogasterQ39603384
Patterns of cell division and cell movement in the formation of the imaginal nervous system in Drosophila melanogasterQ39613433
Cortical flow in animal cellsQ39628270
PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryosQ39758007
PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblastsQ39837256
Lgl mediates apical domain disassembly by suppressing the PAR-3-aPKC-PAR-6 complex to orient apical membrane polarity.Q40287718
Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryoQ40483476
A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarityQ40862977
Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cellsQ40901854
Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblastsQ40913027
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.Q41073451
Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast divisionQ41714205
The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in DrosophilaQ41717902
Asymmetric inheritance of mother versus daughter centrosome in stem cell divisionQ41956545
Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgutQ42077813
Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewalQ42125094
aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division.Q42157298
The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.Q42437062
Miranda Is Required for the Asymmetric Localization of Prospero during Mitosis in DrosophilaQ42443134
Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transportQ42454045
Apical/basal spindle orientation is required for neuroblast homeostasis and neuronal differentiation in Drosophila.Q42457210
Differential functions of G protein and Baz-aPKC signaling pathways in Drosophila neuroblast asymmetric division.Q42457548
miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesisQ42461059
Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae.Q42473975
Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts.Q42480871
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectasymmetric cell divisionQ4812070
P304page(s)2675-2699
P577publication date2009-12-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inGenes & DevelopmentQ1524533
P1476titleDividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
P478volume23

Reverse relations

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Q42504161Expression of the 49 human ATP binding cassette (ABC) genes in pluripotent embryonic stem cells and in early- and late-stage multipotent mesenchymal stem cells: possible role of ABC plasma membrane transporters in maintaining human stem cell pluripo
Q35188323Fly meets yeast: checking the correct orientation of cell division
Q92541388Formation of Polarized, Functional Artificial Cells from Compartmentalized Droplet Networks and Nanomaterials, Using One-Step, Dual-Material 3D-Printed Microfluidics
Q57055355From "the Worm" to "the Worms" and Back Again: The Evolutionary Developmental Biology of Nematodes
Q37897490Gastrointestinal stem cells in self-renewal and cancer
Q42733015Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.
Q48850164Germinal Zones in the Developing Cerebral Cortex of Ferret: Ontogeny, Cell Cycle Kinetics, and Diversity of Progenitors
Q38091661Going vertical: functional role and working principles of the protein Inscuteable in asymmetric cell divisions
Q38014365Gut stem cells in tissue renewal and disease: methods, markers, and myths
Q90110440Hormonal Suppression of Stem Cells Inhibits Symmetric Cell Division and Gastric Tumorigenesis
Q38169087IGF1(CA)19 and IGFBP-3-202A/C gene polymorphism and cancer risk: a meta-analysis
Q39363359Identification of Pancreatic Cancer Stem Cells and Selective Toxicity of Chemotherapeutic Agents
Q37324837Identification of a cancer stem cell-like side population in the HeLa human cervical carcinoma cell line
Q42113553Imperfect asymmetry: The mechanism governing asymmetric partitioning of damaged cellular components during mitosis
Q35196349In vitro generation of human cells with cancer stem cell properties
Q37955139In vitro models
Q35914920In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells
Q36473698Inhibition of mTOR sensitizes breast cancer stem cells to radiation-induced repression of self-renewal through the regulation of MnSOD and Akt.
Q37819572Initial cell type choice in Dictyostelium
Q38239339Insights into brain development and disease from neurogenetic analyses in Drosophila melanogaster
Q41620700Integrated Analysis of Copy Number Variations and Gene Expression Profiling in Hepatocellular carcinoma.
Q48103780Interaction of Spoonbill with Prospero in Drosophila: Implications in neuroblast development.
Q38069041Introduction to stem cells and regenerative medicine
Q42776923Isolation and functional interrogation of adult human prostate epithelial stem cells at single cell resolution.
Q27671529LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways
Q38387100Lethal (2) giant larvae: an indispensable regulator of cell polarity and cancer development
Q42291770Lineage Specification from Prostate Progenitor Cells Requires Gata3-Dependent Mitotic Spindle Orientation
Q26829782Lineage selection and plasticity in the intestinal crypt
Q93163796Liquid-liquid phase separation in artificial cells
Q36928209Lovastatin Decreases the Expression of CD133 and Influences the Differentiation Potential of Human Embryonic Stem Cells
Q37707517MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division
Q28513494Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development
Q37852428Mechanisms for complexity in the brain: generating the insect central complex
Q52623886Mechanisms of Trabecular Formation and Specification During Cardiogenesis.
Q35087768Mechanisms of regulating tissue elongation in Drosophila wing: impact of oriented cell divisions, oriented mechanical forces, and reduced cell size
Q39021636MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells
Q38291096MicroRNAs as Therapeutic Targets and Colorectal Cancer Therapeutics
Q38152747Microtubules and actin crosstalk in cell migration and division
Q28593404Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity
Q55364065Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells.
Q47793757Mitotic spindle misorientation in cancer – out of alignment and into the fire
Q90617354Modeling cell population dynamics
Q39016064Molecular mechanisms of asymmetric divisions in mammary stem cells.
Q35630080Molecular profile of clonal strains of human skeletal stem/progenitor cells with different potencies
Q38134570Moving RNA moves RNA forward
Q24318195Msd1/SSX2IP-dependent microtubule anchorage ensures spindle orientation and primary cilia formation
Q30764907NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells.
Q34505099Nanoparticle labeling identifies slow cycling human endometrial stromal cells
Q36254400Network Inference of pal-1 Lineage-Specific Regulation in the C. elegans Embryo by Structural Equation Modeling
Q36039396Neural Stem Cells inDrosophila: Molecular Genetic Mechanisms Underlying Normal Neural Proliferation and Abnormal Brain Tumor Formation
Q49843515New dimensions of asymmetric division in vertebrates
Q38940597Non-coding RNAs Functioning in Colorectal Cancer Stem Cells
Q38090269Non-enzymatic post-translational protein modifications and proteostasis network deregulation in carcinogenesis
Q36120615Non-invasive, quantitative assessment of the morphology of γ-irradiated human mesenchymal stem cells and periosteal cells using digital holographic microscopy
Q35763355Nonlinear mixed-effects modelling for single cell estimation: when, why, and how to use it
Q35944703Numb downregulation suppresses cell growth and is associated with a poor prognosis of human hepatocellular carcinoma
Q47162554Numb prevents a complete epithelial-mesenchymal transition by modulating Notch signalling.
Q48433826Ontogeny of pioneer neurons in the antennal nervous system of the grasshopper Schistocerca gregaria
Q35744530Organelle segregation during mitosis: lessons from asymmetrically dividing cells.
Q37945958Oriented cell division in vertebrate embryogenesis
Q58547334Orienting Muscle Stem Cells for Regeneration in Homeostasis, Aging, and Disease
Q34569371Ovarian cancer stem cell-like side populations are enriched following chemotherapy and overexpress EZH2.
Q30585966Pharmacological induction of pancreatic islet cell transdifferentiation: relevance to type I diabetes
Q98893983Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics
Q47620027Physical Limits on the Precision of Mitotic Spindle Positioning by Microtubule Pushing forces: Mechanics of mitotic spindle positioning
Q37552600Physical basis of large microtubule aster growth
Q61452256Polarity as a physiological modulator of cell function
Q26830318Polarity in mammalian epithelial morphogenesis
Q33712552Polarized myosin produces unequal-size daughters during asymmetric cell division.
Q58243863Probability density function solutions to a Bessel type pantograph equation
Q41575899Programmed cell death in type II neuroblast lineages is required for central complex development in the Drosophila brain
Q28115044Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma
Q40348586Protein aggregates are associated with replicative aging without compromising protein quality control
Q38107433Random chromosome segregation in mouse intestinal epithelial stem cells.
Q37707515Regulation of stem cell function by protein ubiquitylation
Q26865816Regulatory cells and transplantation tolerance
Q61133296Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells
Q37721761Roles of small regulatory RNAs in determining neuronal identity
Q28513877Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition–like mechanism
Q60934163Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells
Q60300380Skeletal muscle stem cells in comfort and stress
Q41269518Spatial perturbation with synthetic protein scaffold reveals robustness of asymmetric cell division
Q37204606Spindle orientation and epidermal morphogenesis
Q26829174Spindle orientation in mammalian cerebral cortical development
Q28083790Splitting the cell, building the organism: Mechanisms of cell division in metazoan embryos
Q39177046Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up.
Q50743420Stem Cells in the Drosophila Digestive System
Q39834294Stem cell control, oscillations, and tissue regeneration in spatial and non-spatial models.
Q38194814Stem cell decisions: a twist of fate or a niche market?
Q38118084Stem cells behind the barrier.
Q28728633Stem cells in the light of evolution
Q37616850Stemness in human thyroid cancers and derived cell lines: the role of asymmetrically dividing cancer stem cells resistant to chemotherapy
Q28727730Stomatal development: a plant's perspective on cell polarity, cell fate transitions and intercellular communication
Q38200040Structure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells
Q37424094TRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation.
Q34505105Targeting breast cancer stem cells
Q55063443Targeting muscle stem cell intrinsic defects to treat Duchenne muscular dystrophy.
Q83224344Telophase correction refines division orientation in stratified epithelia
Q36251360The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation
Q52313294The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment.
Q26745851The Role of Lymphatic Niches in T Cell Differentiation
Q37899288The Significant Role of Centrosomes in Stem Cell Division and Differentiation
Q34441979The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch
Q41970576The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo
Q47236781The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division
Q26753023The final cut: cell polarity meets cytokinesis at the bud neck in S. cerevisiae
Q91433684The kinases PIG-1 and PAR-1 act in redundant pathways to regulate asymmetric division in the EMS blastomere of C. elegans
Q42108281The labial gene is required to terminate proliferation of identified neuroblasts in postembryonic development of the Drosophila brain
Q26740666The regulation of hematopoietic stem cell populations
Q37802541The secret to life is being different: asymmetric divisions in plant development
Q36145854The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division.
Q30555736The transmission of nuclear pore complexes to daughter cells requires a cytoplasmic pool of Nsp1
Q53055743The tumor suppressor APC differentially regulates multiple β-catenins through the function of axin and CKIα during C. elegans asymmetric stem cell divisions.
Q30524017The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.
Q38444916The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements
Q34627354Tracking adult stem cells.
Q36352412Tracking chromatid segregation to identify human cardiac stem cells that regenerate extensively the infarcted myocardium
Q48239892Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells.
Q38537596Ubiquitin in regulation of spindle apparatus and its positioning: implications in development and disease
Q46581689Ultrastructural features of the differentiating thyroid primordium in the sand lizard (Lacerta agilis L.) from the differentiation of the cellular cords to the formation of the follicular lumen.
Q26991584Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies
Q36576333Where gene discovery turns into systems biology: genome-scale RNAi screens in Drosophila
Q33917414Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling
Q38997845Xihuang Pill () induces mesenchymal-epithelial transition and inhibits loss of apical-basal polarity in colorectal cancer cell through regulating ZEB1-SCRIB loop
Q91827817Zeb1 Regulates the Symmetric Division of Mouse Lewis Lung Carcinoma Stem Cells through Numb mediated by miR-31
Q47071684bHLH-O proteins balance the self-renewal and differentiation of Drosophila neural stem cells by regulating Earmuff expression
Q42426376c-Met in pancreatic cancer stem cells: therapeutic implications.
Q38378086c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Differentiation
Q86711119miR-34a Sets the “Sweet Spot” for Notch in Colorectal Cancer Stem Cells
Q92006467zfh2 controls progenitor cell activation and differentiation in the adult Drosophila intestinal absorptive lineage

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