Balancing self-renewal and differentiation by asymmetric division: insights from brain tumor suppressors in Drosophila neural stem cells

scientific article published on 27 January 2012

Balancing self-renewal and differentiation by asymmetric division: insights from brain tumor suppressors in Drosophila neural stem cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/BIES.201100090
P8608Fatcat IDrelease_fh4x6hsmcfeu5odfcr5nwom7lu
P698PubMed publication ID22287225

P2093author name stringCheng Wang
Hongyan Wang
Kai Chen Chang
P2860cites workHuntingtin is required for mitotic spindle orientation and mammalian neurogenesisQ24294765
The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expressionQ24307809
aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant NumbQ24338740
Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localizationQ24595932
Stem cells, cancer, and cancer stem cellsQ27860878
Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisionsQ28256961
Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcomaQ28261947
Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cellsQ28646359
The PAR proteins: fundamental players in animal cell polarizationQ30434403
A role for a novel centrosome cycle in asymmetric cell divisionQ30480419
Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain developmentQ30481439
Identification of Drosophila type II neuroblast lineages containing transit amplifying ganglion mother cellsQ30492732
dFezf/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila.Q30973931
Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions.Q33841767
The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in DrosophilaQ34145953
Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitorsQ34477283
The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblastsQ34519483
Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organizationQ34519492
The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell divisionQ34532924
Flies without centriolesQ34543650
Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cellsQ34586479
Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon.Q34618385
Drosophila neuroblasts retain the daughter centrosome.Q34769087
Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in DrosophilaQ42730924
numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryosQ44665387
The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.Q44742346
Proliferation pattern of postembryonic neuroblasts in the brain of Drosophila melanogasterQ45300018
Asymmetric segregation of Numb and Prospero during cell divisionQ46547833
Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteinsQ47069999
Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblastsQ47070895
Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.Q47071360
Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewalQ47071599
prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in DrosophilaQ47071678
Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cellsQ47071726
Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewalQ47071774
Cnn dynamics drive centrosome size asymmetry to ensure daughter centriole retention in Drosophila neuroblastsQ47071907
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogasterQ47072023
The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila.Q47072815
Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localizationQ47881793
Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instabilityQ49037799
Epigenetic licensing of germline gene expression by maternal RNA in C. elegans.Q51855441
Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in theDrosophilaoptic lobeQ51901613
Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development.Q51905086
Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate.Q52190224
The prospero gene specifies cell fates in the drosophila central nervous systemQ52444632
Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation.Q52663442
The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors.Q52691731
Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila.Q52713517
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblastsQ35221182
Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientationQ35503704
Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobeQ35606421
Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in DrosophilaQ35642076
The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientationQ35670607
Drosophila brain tumor metastases express both neuronal and glial cell type markersQ35768202
Brainy but not too brainy: starting and stopping neuroblast divisions in Drosophila.Q35996908
Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epitheliaQ36324711
The PAR-aPKC system: lessons in polarityQ36416725
Regulation of imaginal disc growth by tumor-suppressor genes in DrosophilaQ36548698
The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related deathQ36935988
Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions.Q37111119
At the crossroads of polarity, proliferation and apoptosis: the use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppressionQ37370141
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complexQ37694408
Endocytosis and intracellular trafficking of Notch and its ligandsQ37785196
Metastatic ability of Drosophila tumors depends on MMP activityQ38305585
The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elementsQ38444916
Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisionsQ38492936
Apical-basal polarity in Drosophila neuroblasts is independent of vesicular traffickingQ39123911
Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cellsQ39797461
PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblastsQ39837256
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.Q40664929
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.Q41073451
Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepitheliaQ41268202
Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.Q41700895
Modes of protein movement that lead to the asymmetric localization of partner of Numb during Drosophila neuroblast divisionQ41714205
The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in DrosophilaQ41717902
Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewalQ42125094
aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division.Q42157298
Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progressionQ42438368
Miranda is required for the asymmetric localization of Prospero during mitosis in DrosophilaQ42443134
Apical/basal spindle orientation is required for neuroblast homeostasis and neuronal differentiation in Drosophila.Q42457210
Differential functions of G protein and Baz-aPKC signaling pathways in Drosophila neuroblast asymmetric division.Q42457548
Identification of Miranda protein domains regulating asymmetric cortical localization, cargo binding, and cortical releaseQ42466623
G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitorsQ42481073
Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell divisionQ42485369
A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in DrosophilaQ42486222
An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts.Q42494446
Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblastQ42497214
The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblastsQ42497218
Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells.Q42509178
Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous systemQ42511782
Role of inscuteable in orienting asymmetric cell divisions in DrosophilaQ42522271
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
brain tumorQ233309
neural stem cellQ2944097
P304page(s)301-310
P577publication date2012-01-27
P1433published inBioEssaysQ4914614
P1476titleBalancing self-renewal and differentiation by asymmetric division: insights from brain tumor suppressors in Drosophila neural stem cells
P478volume34

Reverse relations

cites work (P2860)
Q34723950ASYMMETRIC CELL DIVISION: IMPLICATIONS FOR GLIOMA DEVELOPMENT AND TREATMENT.
Q38217971Control of neural stem cell self-renewal and differentiation in Drosophila
Q38079704Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics
Q38207120Drosophila neural stem cells in brain development and tumor formation
Q36937660Early-born neurons in type II neuroblast lineages establish a larval primordium and integrate into adult circuitry during central complex development in Drosophila
Q37593628Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors
Q47962979ING5 activity in self-renewal of glioblastoma stem cells via calcium and follicle stimulating hormone pathways.
Q48132751MiR200 and miR302: Two Big Families Influencing Stem Cell Behavior.
Q41757844Multipotent hematopoietic progenitors divide asymmetrically to create progenitors of the lymphomyeloid and erythromyeloid lineages
Q26784363Proliferation control in neural stem and progenitor cells
Q37620996The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages
Q37707821The SCFSlimb E3 ligase complex regulates asymmetric division to inhibit neuroblast overgrowth.
Q34441979The bHLH repressor Deadpan regulates the self-renewal and specification of Drosophila larval neural stem cells independently of Notch
Q41785743Uncovering the link between malfunctions in Drosophila neuroblast asymmetric cell division and tumorigenesis
Q50323081Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II.

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