E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein

scientific article published on 22 November 2006

E6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.01712-06
P932PMC publication ID1797514
P698PubMed publication ID17121805

P50authorMasatoshi FujitaQ42705377
P2093author name stringMako Narisawa-Saito
Tohru Kiyono
Takashi Yugawa
Keisuke Handa
Shin-Ichi Ohno
P2860cites workEnhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 proteinQ22008543
The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phaseQ22011189
Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissuesQ24309659
Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC proteinQ24310777
Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor proteinQ24311317
The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteinsQ24315710
Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53Q24321129
Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteinsQ24527216
Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligaseQ24551145
Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6-AP complexQ24561609
Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteinsQ24622878
Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor proteinQ24654803
Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerizationQ27641957
Overlapping gene structure of human VLCAD and DLG4Q28212613
PDZ domains - common players in the cell signalingQ28240317
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95Q28290055
HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradationQ28360379
Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressorQ28571122
PSD-95 involvement in maturation of excitatory synapsesQ29616167
PDZ Domain Proteins: Plug and Play!Q30164767
Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasomeQ33292234
Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradationQ33292379
Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligaseQ33807681
Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradationQ34141231
The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivoQ35020321
Successful immortalization of endometrial glandular cells with normal structural and functional characteristicsQ35843291
Suppression of cellular proliferation by the papillomavirus E2 proteinQ35852233
The pCL vector system: rapid production of helper-free, high-titer, recombinant retrovirusesQ35866801
Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.Q36660357
Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promotersQ36807559
Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6.Q40315476
HPV E6 specifically targets different cellular pools of its PDZ domain-containing tumour suppressor substrates for proteasome-mediated degradationQ40513963
Molecular mechanisms of TNF-alpha-induced ceramide formation in human glioma cells: P53-mediated oxidant stress-dependent and -independent pathwaysQ40558195
Establishment of immortal normal and ataxia telangiectasia fibroblast cell lines by introduction of the hTERT geneQ40703207
PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domainQ40928878
Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblastQ42497214
The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblastsQ42497218
The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complexQ42613510
Degradation of hDlg and MAGIs by human papillomavirus E6 is E6-AP-independentQ45078112
Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.Q52547859
Activity of the human papillomavirus E6 PDZ-binding motif correlates with an enhanced morphological transformation of immortalized human keratinocytes.Q52552544
HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligaseQ73501403
Proliferation, cell cycle exit, and onset of terminal differentiation in cultured keratinocytes: pre-programmed pathways in control of C-Myc and Notch1 prevail over extracellular calcium signalsQ81688972
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)1379-1389
P577publication date2006-11-22
P1433published inJournal of VirologyQ1251128
P1476titleE6AP-dependent degradation of DLG4/PSD95 by high-risk human papillomavirus type 18 E6 protein
P478volume81

Reverse relations

cites work (P2860)
Q36106815A Drosophila Model of HPV E6-Induced Malignancy Reveals Essential Roles for Magi and the Insulin Receptor
Q53184803A critical role of MYC for transformation of human cells by HPV16 E6E7 and oncogenic HRAS.
Q39625147A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose loss accompanies disruption of tight junctions
Q53285916Abnormal distribution of hDlg and PTEN in premalignant lesions and invasive cervical cancer.
Q39013544Activation of telomerase by HPVs
Q28603342Comparative Transcriptomic Approaches Exploring Contamination Stress Tolerance in Salix sp. Reveal the Importance for a Metaorganismal de Novo Assembly Approach for Nonmodel Plants
Q28552533Computational Identification of Novel Stage-Specific Biomarkers in Colorectal Cancer Progression
Q33620294Constitutional haploinsufficiency of tumor suppressor genes in mentally retarded patients with microdeletions in 17p13.1.
Q30431944Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60-dependent transcriptional regulation and apoptotic pathway
Q43250013Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexes
Q45364775Double demonstration of oncogenic high risk human papilloma virus DNA and HPV-E7 protein in oral cancers
Q35531181Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses
Q37448007Enhanced Stabilization of MCL1 by the Human T-Cell Leukemia Virus Type 1 bZIP Factor Is Modulated by Blocking the Recruitment of Cullin 1 to the SCF Complex
Q35323930Expression of polarity genes in human cancer
Q52392798Human Papillomavirus E6 interaction with cellular PDZ domain proteins modulates YAP nuclear localization.
Q37169150Human papilloma virus (HPV) and host cellular interactions
Q34980270Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis
Q30443519Human papillomavirus E6 regulates the cytoskeleton dynamics of keratinocytes through targeted degradation of p53
Q37315925Human papillomavirus and molecular considerations for cancer risk
Q38026999Human papillomaviruses and the specificity of PDZ domain targeting.
Q37333627Human papillomaviruses, cervical cancer and cell polarity
Q52366931IntLIM: integration using linear models of metabolomics and gene expression data.
Q37327240Manipulation of the ubiquitin-proteasome pathway by small DNA tumor viruses
Q36840769Modeling migration and metastasis in Drosophila
Q35532348Modeling tumor invasion and metastasis in Drosophila
Q64256422Mucosal and Cutaneous Human Papillomavirus Infections and Cancer Biology
Q37336719NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes
Q30410553Papillomavirus E6 oncoproteins
Q64992613Regulating the human HECT E3 ligases.
Q35856917Regulation of Notch1 gene expression by p53 in epithelial cells
Q91983237Roles for E1-independent replication and E6-mediated p53 degradation during low-risk and high-risk human papillomavirus genome maintenance
Q33873284Roles of the PDZ-binding motif of HPV 16 E6 protein in oncogenic transformation of human cervical keratinocytes
Q44081167Surface plasmon resonance analysis of the binding of high-risk mucosal HPV E6 oncoproteins to the PDZ1 domain of the tight junction protein MAGI-1.
Q39429557Telomerase Induction in HPV Infection and Oncogenesis
Q59351344The Deubiquitinase USP46 Is Essential for Proliferation and Tumor Growth of HPV-Transformed Cancers
Q35895297The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy
Q24680527The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity
Q84450757The stability of the human papillomavirus E6 oncoprotein is E6AP dependent
Q26770053Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
Q35479045WIF1 is a frequent target for epigenetic silencing in squamous cell carcinoma of the cervix
Q36252643Whole Exome Sequencing of Growing and Non-Growing Cutaneous Neurofibromas from a Single Patient with Neurofibromatosis Type 1

Search more.