CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles

scientific article

CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00276-16
P932PMC publication ID4944274
P698PubMed publication ID27194762

P50authorThumbi Ndung'uQ1952473
Bruce D. WalkerQ23770361
Christina F Thobakgale-TshabalalaQ58828199
Philip J. R. GoulderQ72618990
Zenele MncubeQ79068601
Mary van der StokQ79069730
Nasreen IsmailQ79069804
Julia G PradoQ90811762
Zaza M NdhlovuQ91595972
Catherine KoofhethileQ100304296
Lungile MkhizeQ117222358
P2093author name stringNonhlanhla Yende
P2860cites workCommon genetic variation and the control of HIV-1 in humansQ21092450
Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infectionQ24564779
HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressorsQ24676982
The influence of HLA genotype on AIDSQ28202903
Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognitionQ28282470
Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virusQ28302762
A combination of defective DNA and protective host factors are found in a set of HIV-1 ancestral LTNPsQ58415384
Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)Q61365620
Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progressionQ71803154
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDSQ73034306
AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesisQ81481381
The major genetic determinants of HIV-1 control affect HLA class I peptide presentationQ29417018
Recovery of replication-competent HIV despite prolonged suppression of plasma viremiaQ29615995
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cellsQ29616205
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rateQ33558599
Impaired replication capacity of acute/early viruses in persons who become HIV controllersQ33963989
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.Q34009945
Additive contribution of HLA class I alleles in the immune control of HIV-1 infectionQ34120809
Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parametersQ34178349
Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasmaQ34332166
Association between virus-specific T-cell responses and plasma viral load in human immunodeficiency virus type 1 subtype C infectionQ34465724
Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infectionQ35164457
HIV and SIV CTL escape: implications for vaccine designQ35852284
Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responsesQ36086732
Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutationsQ36238124
Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infantsQ36315692
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infectionQ36399423
Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing childQ36684112
Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changesQ36845893
Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+ T-cell epitope in p1 Gag protein.Q37033282
HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703Q37081581
Pressure from TRIM5α contributes to control of HIV-1 replication by individuals expressing protective HLA-B allelesQ37123118
HLA footprints on human immunodeficiency virus type 1 are associated with interclade polymorphisms and intraclade phylogenetic clusteringQ37157122
Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infectionQ37356088
HIV and HLA class I: an evolving relationshipQ38045636
Viral suppression of multiple escape mutants by de novo CD8(+) T cell responses in a human immunodeficiency virus-1 infected elite suppressorQ38425723
First demonstration of a lack of viral sequence evolution in a nonprogressor, defining replication-incompetent HIV-1 infectionQ38451424
HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus controlQ38610690
Gag cytotoxic T lymphocyte escape mutations can increase sensitivity of HIV-1 to human TRIM5alpha, linking intrinsic and acquired immunityQ38959897
Widespread impact of HLA restriction on immune control and escape pathways of HIV-1Q41814777
Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.Q41827503
HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcomeQ41937295
Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virusQ42737606
Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytesQ43163152
Evolution of HIV-1 in an HLA-B*57-positive patient during virologic escape.Q44082963
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.Q44291572
Long-term nonprogressive disease among untreated HIV-infected individuals: clinical implications of understanding immune control of HIV.Q44910750
Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.Q53588591
CD8+ T-cell responses to different HIV proteins have discordant associations with viral loadQ57259602
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)6818-6831
P577publication date2016-05-18
P1433published inJournal of VirologyQ1251128
P1476titleCD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles
P478volume90

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cites work (P2860)
Q92781215Control of the HIV-1 Load Varies by Viral Subtype in a Large Cohort of African Adults With Incident HIV-1 Infection
Q59332866Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
Q37615584Factors Associated with the Size of HIV DNA Reservoir
Q47174478Factors Leading to the Loss of Natural Elite Control of HIV-1 Infection.
Q64100454Harnessing CD8 T Cells Under HIV Antiretroviral Therapy
Q59349690Mechanisms of abrupt loss of virus control in a cohort of previous HIV controllers
Q92538798The Safety and Immunogenicity of GTU®MultiHIV DNA Vaccine Delivered by Transcutaneous and Intramuscular Injection With or Without Electroporation in HIV-1 Positive Subjects on Suppressive ART
Q40163730The association of HIV-1 Gag-specific IgG antibodies with natural control of HIV-1 infection in individuals not carrying HLA-B*57: 01 is only observed in viremic controllers

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