Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants

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Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00624-07
P932PMC publication ID2169079
P698PubMed publication ID17881456

P50authorHoosen CoovadiaQ20656400
Bruce D. WalkerQ23770361
Christina F Thobakgale-TshabalalaQ58828199
Krista L. DongQ60055605
Philip J. R. GoulderQ72618990
Photini KiepielaQ77767253
Andrew PrendergastQ77768844
Nompumelelo MkhwanaziQ79068751
Wendy P MphatsweQ91807889
Gareth Tudor-WilliamsQ95647857
Ayanda CengimboQ114444551
Prakash JeenaQ114576975
Sharon ReddyQ117221669
Eshia S MoodleyQ117221676
Dhanwanthie RamduthQ117221679
Natasha BlanckenbergQ117221709
Raziya BobatQ117271934
P2093author name stringChantal de Pierres
Gupreet Kindra
P2860cites workSelection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infectionQ24564623
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infectionQ24645815
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cellsQ29616205
Longitudinal assessment of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon responses during the first year of life in HIV-1-infected infantsQ33843438
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trialQ33873955
Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cellsQ33981572
Unique acquisition of cytotoxic T-lymphocyte escape mutants in infant human immunodeficiency virus type 1 infectionQ33987347
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.Q34468117
Immunologic control of HIV-1.Q34511495
Mature CD8(+) T lymphocyte response to viral infection during fetal lifeQ35019349
Comparison of human immunodeficiency virus type 1 viral loads in Kenyan women, men, and infants during primary and early infectionQ35020912
HIV and SIV CTL escape: implications for vaccine designQ35852284
Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.Q36403330
Immune escape precedes breakthrough human immunodeficiency virus type 1 viremia and broadening of the cytotoxic T-lymphocyte response in an HLA-B27-positive long-term-nonprogressing childQ36684112
Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial.Q38882753
Infrequent detection of HIV-1-specific, but not cytomegalovirus-specific, CD8(+) T cell responses in young HIV-1-infected infantsQ40764424
Co-evolution of human immunodeficiency virus and cytotoxic T-lymphocyte responses.Q41672909
Progress in defining CD4 helper cell responses in chronic viral infectionsQ42109893
HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversityQ43438499
Viral load and disease progression in infants infected with human immunodeficiency virus type 1. Women and Infants Transmission Study GroupQ44142380
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.Q44291572
Early HIV-specific cytotoxic T lymphocytes and disease progression in children born to HIV-infected mothersQ45280425
Functional patterns of HIV-1-specific CD4 T-cell responses in children are influenced by the extent of virus suppression and exposureQ45409477
Association of strong virus-specific CD4 T cell responses with efficient natural control of primary HIV-1 infectionQ45654002
Reconstitution of virus-specific CD4 proliferative responses in pediatric HIV-1 infectionQ45705725
Longitudinal human immunodeficiency virus type 1 load in the italian seroconversion study: correlates and temporal trends of virus loadQ45747378
Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected childrenQ45854297
High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxisQ46175630
HIV-specific CD8+ T cell function in children with vertically acquired HIV-1 infection is critically influenced by age and the state of the CD4+ T cell compartmentQ46498993
Early proliferation of CCR5(+) CD38(+++) antigen-specific CD4(+) Th1 effector cells during primary HIV-1 infection.Q51991924
Association between HIV-specific T helper responses and CTL activities in pediatric AIDS.Q52030360
HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.Q53671883
Immune control of HIV-1 after early treatment of acute infectionQ56961920
CD8+ T-cell responses to different HIV proteins have discordant associations with viral loadQ57259602
Differential Immunogenicity of HIV‐1 Clade C Proteins in Eliciting CD8+and CD4+Cell ResponsesQ57259616
Immunopathogenic mechanisms of HIV infectionQ71016167
HIV-1-specific cytotoxic T lymphocyte responses in the first year of lifeQ72896097
Diminished HIV-specific CTL activity is associated with lower type 1 and enhanced type 2 responses to HIV-specific peptides during perinatal HIV infectionQ73433333
Cytotoxic T lymphocytes generation capacity in early life with particular reference to HIVQ77122423
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)12775-12784
P577publication date2007-09-19
P1433published inJournal of VirologyQ1251128
P1476titleHuman immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants
P478volume81

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cites work (P2860)
Q46191742Activation of cord blood myeloid dendritic cells by Trypanosoma cruzi and parasite-specific antibodies, proliferation of CD8+ T cells, and production of IFN-γ.
Q33886570Association of HIV diversity and survival in HIV-infected Ugandan infants.
Q35592229Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection
Q34677320CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles
Q91843704Deep sequence analysis of HIV adaptation following vertical transmission reveals the impact of immune pressure on the evolution of HIV
Q37271461Deficiency of HIV-Gag-specific T cells in early childhood correlates with poor viral containment
Q28475576Dendritic cells reveal a broad range of MHC class I epitopes for HIV-1 in persons with suppressed viral load on antiretroviral therapy
Q35664125Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection
Q59332866Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
Q41499429Functional Exhaustion Limits CD4+ and CD8+ T-Cell Responses to Congenital Cytomegalovirus Infection.
Q35581936HIV-specific gag responses in early infancy correlate with clinical outcome and inversely with viral load
Q34190667HLA-Cw*03-restricted CD8+ T-cell responses targeting the HIV-1 gag major homology region drive virus immune escape and fitness constraints compensated for by intracodon variation
Q37386643Identification of human immunodeficiency virus-1 specific CD8+ and CD4+ T cell responses in perinatally-infected infants and their mothers
Q34033051Immunity to HIV in Early Life
Q34195857Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality
Q37080573Immunology of pediatric HIV infection
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Q38890564Impact of maternal HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health
Q42214247In-utero infection with HIV-1 associated with suppressed lymphoproliferative responses at birth.
Q47812016Infants with late breast milk acquisition of HIV-1 generate interferon-gamma responses more rapidly than infants with early peripartum acquisition
Q35076519Influence of Gag-protease-mediated replication capacity on disease progression in individuals recently infected with HIV-1 subtype C.
Q35164457Limited immunogenicity of HIV CD8+ T-cell epitopes in acute Clade C virus infection
Q37738467Low level of HIV-1 evolution after transmission from mother to child
Q38699481Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity
Q38773102Paediatric HIV infection: the potential for cure
Q37243687Paediatric non-progression following grandmother-to-child HIV transmission
Q36053228Preservation HIV-1-specific IFNγ+ CD4+ T-cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial
Q54219253Recovery of effective hiv-specific cd4+ t-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia.
Q33558599Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate
Q41923263Role of HIV-specific CD8(+) T cells in pediatric HIV cure strategies after widespread early viral escape.
Q37330751Scientific consultation on cell mediated immunity (CMI) in dengue and dengue vaccine development
Q42535693Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection
Q37294337Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life
Q92049906Simian-Human Immunodeficiency Virus SHIV.CH505-Infected Infant and Adult Rhesus Macaques Exhibit Similar Env-Specific Antibody Kinetics, despite Distinct T-Follicular Helper and Germinal Center B Cell Landscapes
Q38037339The impact of differential antiviral immunity in children and adults
Q58843474Trypanosoma cruzi activates cord blood myeloid dendritic cells independently of cell infection
Q37086886Viral Evolution and Cytotoxic T Cell Restricted Selection in Acute Infant HIV-1 Infection
Q48139618Why are preterm newborns at increased risk of infection?

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