Development of human anti-murine T-cell receptor antibodies in both responding and nonresponding patients enrolled in TCR gene therapy trials

scientific article

Development of human anti-murine T-cell receptor antibodies in both responding and nonresponding patients enrolled in TCR gene therapy trials is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-10-1280
P932PMC publication ID3058233
P698PubMed publication ID21138872

P50authorSteven RosenbergQ2347448
P2093author name stringCor H J Lamers
Richard A Morgan
Zhili Zheng
Marc R Theoret
Jeremy L Davis
P2860cites workHerpes simplex virus thymidine kinase gene transfer for controlled graft-versus-host disease and graft-versus-leukemia: clinical follow-up and improved new vectorsQ45753115
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapyQ45858516
T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patientsQ45876112
Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cellsQ48587406
Tumor-specific cytolysis by lymphocytes infiltrating human melanomasQ69738303
Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experienceQ83222464
Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigenQ24623215
Cancer regression in patients after transfer of genetically engineered lymphocytesQ24654976
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytesQ24676216
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune responseQ29619095
T cell receptor gene therapy: strategies for optimizing transgenic TCR pairingQ33528336
T cell receptor (TCR) gene therapy to treat melanoma: lessons from clinical and preclinical studiesQ33530527
Targeting p53 as a general tumor antigenQ33638172
Immune responses to adenovirus and adeno-associated virus in humans.Q33874473
Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cellsQ33927506
Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transductionQ34354588
Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR.Q34657661
Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stabilityQ36286127
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancerQ36299662
Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cellsQ36326582
Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytesQ36327157
Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functionsQ36713758
Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognitionQ37197942
Enhanced T cell receptor gene therapy for cancerQ37702226
The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignanciesQ40165690
Immune response to fetal calf serum by two adenosine deaminase-deficient patients after T cell gene therapyQ44134992
Persistence and expression of the adenosine deaminase gene for 12 years and immune reaction to gene transfer components: long-term results of the first clinical gene therapy trial.Q44232574
Ovarian cancer BRCA1 gene therapy: Phase I and II trial differences in immune response and vector stability.Q45081770
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
patientQ181600
gene therapyQ213901
P304page(s)5852-5861
P577publication date2010-12-01
P1433published inClinical Cancer ResearchQ332253
P1476titleDevelopment of human anti-murine T-cell receptor antibodies in both responding and nonresponding patients enrolled in TCR gene therapy trials
P478volume16

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