The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231.

scientific article

The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/15.15.5963
P932PMC publication ID306061
P698PubMed publication ID3627975
P5875ResearchGate publication ID19533906

P2093author name stringKozma SC
Bos JL
Hynes NE
Groner B
Buser K
Bogaard ME
Saurer SM
P2860cites workDetection of specific sequences among DNA fragments separated by gel electrophoresisQ25939003
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemiaQ27861076
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoterQ29614259
Breast tumor cell lines from pleural effusionsQ34209613
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.Q34708404
Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effectsQ35590255
Analysis of the transforming potential of the human H-ras gene by random mutagenesisQ36264166
New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell lineQ36885249
New Human Transforming Genes Detected by a Tumorigenicity AssayQ36947151
A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patientQ37565544
Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemiaQ38352393
The molecular genetics of cellular oncogenesQ40201361
A human gastric carcinoma contains a single mutated and an amplified normal allele of the Ki-ras oncogeneQ40560010
Biological properties of human c-Ha-ras1 genes mutated at codon 12.Q42817584
New Method for Detecting Cellular Transforming GenesQ42824470
The oncogenic activation of human p21ras by a novel mechanismQ44418236
Characterization of a human colon/lung carcinoma oncogeneQ59086201
A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotidesQ69022841
P433issue15
P407language of work or nameEnglishQ1860
P921main subjectbreast carcinomaQ18555947
P304page(s)5963-5971
P577publication date1987-08-01
P1433published inNucleic Acids ResearchQ135122
P1476titleThe human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231.
P478volume15

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cites work (P2860)
Q39979475A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.
Q40070223A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells
Q42831336A potent protein-tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor-expressing tumor cells in vitro and in vivo
Q42803597Activation of c-Ki-ras coexists with c-myc amplification in cells from a nude mouse tumor induced by the human breast carcinoma cell line SW 613-S.
Q24564358Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences
Q40341063Anandamide inhibits adhesion and migration of breast cancer cells
Q58605496Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction
Q21195230Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation
Q37141501Breast cancer metastasis suppressor-1 differentially modulates growth factor signaling.
Q30431290CD147, CD44, and the epidermal growth factor receptor (EGFR) signaling pathway cooperate to regulate breast epithelial cell invasiveness
Q47123785Combined targeting of Raf and Mek synergistically inhibits tumorigenesis in triple negative breast cancer model systems
Q70267772Conformational effects of the substitution of Arg for Gly 13 in the ras oncogene-encoded P21 protein
Q37284069Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway
Q24303568DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth
Q34769614Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells
Q39281631Downregulation of tropomyosin-1 in squamous cell carcinoma of esophagus, the role of Ras signaling and methylation
Q30575256E-cadherin-downregulation and RECK-upregulation are coupled in the non-malignant epithelial cell line MCF10A but not in multiple carcinoma-derived cell lines
Q37042957Early and Late Events in the Development of Human Breast Cancer
Q33893378Epidermal growth factor receptor dependence of radiation-induced transcription factor activation in human breast carcinoma cells
Q38997782Evidence for aldosterone-dependent growth of renal cell carcinoma
Q33549613Function-based gene identification using enzymatically generated normalized shRNA library and massive parallel sequencing.
Q33686865Functional diversity of gro gene expression in human fibroblasts and mammary epithelial cells
Q34066386GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines
Q25257668HER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cells
Q37420053High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: interaction with IQ motif-containing factors
Q37380664Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells
Q43744383Human breast cancer MDA-MB-231 cells fail to express the neurofibromin protein, lack its type I mRNA isoform and show accumulation of P-MAPK and activated Ras.
Q41727247IGF-independent regulation of breast cancer growth by IGF binding proteins
Q37114859Igf1r as a therapeutic target in a mouse model of basal-like breast cancer
Q55176494Infrequent ras mutation in human stomach cancers.
Q91474380Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation
Q37213805Integrated analysis of breast cancer cell lines reveals unique signaling pathways
Q33320695K-ras mutations in sinonasal cancers in relation to wood dust exposure
Q36482942Lipocalin 2 is a novel regulator of angiogenesis in human breast cancer
Q34087168Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells
Q36070110Mispair formation in DNA can involve rare tautomeric forms in the template
Q23912247Mutant c-Ki-ras p21 protein in chemical carcinogenesis in humans exposed to vinyl chloride
Q33825046Mutant p53-induced up-regulation of mitogen-activated protein kinase kinase 3 contributes to gain of function
Q35770590Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo
Q36081804Prostaglandin E2 production and metabolism in human breast cancer cells and breast fibroblasts. Regulation by inflammatory mediators
Q37446199Protein kinase Cdelta supports survival of MDA-MB-231 breast cancer cells by suppressing the ERK1/2 pathway
Q72452835Raf-1 protein expression in human breast cancer cells
Q40658383Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis
Q34407524Ribosome-induced tuning of GTP hydrolysis by a translational GTPase
Q52007365Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-beta.
Q36686648Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype
Q34352727TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells
Q35973719Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription
Q33823577Targeting signal transduction pathways to eliminate chemotherapeutic drug resistance and cancer stem cells.
Q37427689The EGF receptor system as a target for antitumor therapy
Q40456230The antitumor efficacy of anti-p21Ras scFv mediated by the dual-promoter-regulated recombinant adenovirus KGHV300.
Q37041619The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells
Q38206214The polymerase chain reaction: an improved method for the analysis of nucleic acids
Q37649657The proto-oncogene KRAS is targeted by miR-200c
Q34316122The ras signaling pathway in mammary tumorigenesis and metastasis.
Q36486913The role of ras gene expression and transforming growth factor α production in the etiology and progression of rodent and human breast cancer
Q74377212The use of molecular markers in farnesyltransferase inhibitor (FTI) therapy of breast cancer
Q54331857Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells.
Q36766981Transgenic mice carrying the mouse mammary tumor virus ras fusion gene: distinct effects in various tissues
Q40990697p53 Trans-Dominantly Suppresses Tumor Formation of Human Breast Cancer Cells Mediated by Retroviral Bulk Infection without Marker Gene Selection: An Expeditious In Vitro Protocol with Implications towards Gene Therapy

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