| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2007PNAS..10416504S |
| P356 | DOI | 10.1073/PNAS.0708258104 |
| P932 | PMC publication ID | 2034228 |
| P698 | PubMed publication ID | 17925435 |
| P5875 | ResearchGate publication ID | 5920472 |
| P50 | author | Howard Ronald Kaback | Q1562621 |
| Wayne L. Hubbell | Q7976400 | ||
| P2093 | author name string | Irina Smirnova | |
| Vladimir Kasho | |||
| Christian Altenbach | |||
| Jun-Yong Choe | |||
| P2860 | cites work | Interhelical packing modulates conformational flexibility in the lactose permease of Escherichia coli | Q38325976 |
| A mutation in the lactose permease of Escherichia coli that decreases conformational flexibility and increases protein stability | Q38356876 | ||
| Equilibrium between two forms of the lac carrier protein in energized and nonenergized membrane vesicles from Escherichia coli | Q38359212 | ||
| Interresidual distance determination by four-pulse double electron-electron resonance in an integral membrane protein: the Na+/proline transporter PutP of Escherichia coli | Q40278902 | ||
| Watching proteins move using site-directed spin labeling | Q40933370 | ||
| Tertiary contacts of helix V in the lactose permease determined by site-directed chemical cross-linking in situ | Q41608922 | ||
| Thiol cross-linking of cytoplasmic loops in the lactose permease of Escherichia coli | Q41724640 | ||
| Proteomics on full-length membrane proteins using mass spectrometry | Q41729427 | ||
| Assessing oligomerization of membrane proteins by four-pulse DEER: pH-dependent dimerization of NhaA Na+/H+ antiporter of E. coli. | Q41867016 | ||
| Direct sugar binding to LacY measured by resonance energy transfer | Q42059057 | ||
| Molecular motion of spin labeled side chains in alpha-helices: analysis by variation of side chain structure | Q43573920 | ||
| Binding of hydrophobic D-galactopyranosides to the lactose permease of Escherichia coli | Q44186755 | ||
| Motion of spin label side chains in cellular retinol-binding protein: correlation with structure and nearest-neighbor interactions in an antiparallel beta-sheet | Q44800764 | ||
| Cysteine-scanning mutagenesis of transmembrane domain XII and the flanking periplasmic loop in the lactose permease of EScherichia coli. | Q46037270 | ||
| Cysteine-scanning mutagenesis of helix VI and the flanking hydrophilic domains on the lactose permease of Escherichia coli | Q46081376 | ||
| Transmembrane helix tilting and ligand-induced conformational changes in the lactose permease determined by site-directed chemical crosslinking in situ | Q46173447 | ||
| Cysteine-scanning mutagenesis of helix IV and the adjoining loops in the lactose permease of Escherichia coli: Glu126 and Arg144 are essential. off. | Q46390020 | ||
| Distances between the b-subunits in the tether domain of F(0)F(1)-ATP synthase from E. coli | Q46501999 | ||
| Cysteine-scanning mutagenesis of helix II and flanking hydrophilic domains in the lactose permease of Escherichia coli | Q46532408 | ||
| cys154 Is important for lac permease activity in Escherichia coli. | Q54791761 | ||
| DeerAnalysis2006—a comprehensive software package for analyzing pulsed ELDOR data | Q56221696 | ||
| Dead-Time Free Measurement of Dipole–Dipole Interactions between Electron Spins | Q58878339 | ||
| Fourier transform infrared analysis of purified lactose permease: a monodisperse lactose permease preparation is stably folded, alpha-helical, and highly accessible to deuterium exchange | Q77501875 | ||
| Coarse-grained molecular dynamics simulations of membrane proteins and peptides | Q79372145 | ||
| MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures | Q26778412 | ||
| Structural changes in the calcium pump accompanying the dissociation of calcium | Q27639472 | ||
| Structure and mechanism of the lactose permease of Escherichia coli | Q27641768 | ||
| Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli | Q27641769 | ||
| Structural determinants of nitroxide motion in spin-labeled proteins: Tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme | Q27644663 | ||
| Structural determination of wild-type lactose permease | Q27648335 | ||
| Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria | Q27730864 | ||
| XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density | Q27861034 | ||
| The CCP4 suite: programs for protein crystallography | Q27861090 | ||
| The kamikaze approach to membrane transport | Q28210636 | ||
| Structure of the multidrug transporter EmrD from Escherichia coli | Q28238417 | ||
| Reduced surface: an efficient way to compute molecular surfaces | Q29617526 | ||
| Crystal structures of spin labeled T4 lysozyme mutants: implications for the interpretation of EPR spectra in terms of structure. | Q30327038 | ||
| Substrate-dependent unfolding of the energy coupling motif of a membrane transport protein determined by double electron-electron resonance | Q30441272 | ||
| Site-directed alkylation and the alternating access model for LacY. | Q30478719 | ||
| Sugar transport across lactose permease probed by steered molecular dynamics | Q30479746 | ||
| A new spin on protein dynamics | Q34691381 | ||
| Distance measurements in the nanometer range by pulse EPR. | Q35034788 | ||
| Sugar binding and protein conformational changes in lactose permease | Q35128998 | ||
| Single-molecule FRET reveals sugar-induced conformational dynamics in LacY. | Q35921600 | ||
| Sugar binding in lactose permease: anomeric state of a disaccharide influences binding structure | Q36016281 | ||
| Lessons from lactose permease | Q36475370 | ||
| Fourier transform infrared spectroscopy reveals a rigid alpha-helical assembly for the tetrameric Streptomyces lividans K+ channel | Q37381229 | ||
| Sequence alignment and homology threading reveals prokaryotic and eukaryotic proteins similar to lactose permease | Q37447578 | ||
| Energetics of ligand-induced conformational flexibility in the lactose permease of Escherichia coli | Q37475482 | ||
| Ligand-induced conformational changes in the lactose permease of Escherichia coli: evidence for two binding sites | Q38302054 | ||
| Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY. | Q38315163 | ||
| Cysteine scanning mutagenesis of putative transmembrane helices IX and X in the lactose permease of Escherichia coli | Q38318851 | ||
| Exchange, efflux, and substrate binding by cysteine mutants of the lactose permease of Escherichia coli | Q38319014 | ||
| P433 | issue | 42 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 16504-16509 | |
| P577 | publication date | 2007-10-09 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Sugar binding induces an outward facing conformation of LacY. | |
| P478 | volume | 104 |
| Q37311480 | A 3D structure model of the melibiose permease of Escherichia coli represents a distinctive fold for Na+ symporters |
| Q37778543 | A biophysical glance at the outer surface of the membrane transporter SGLT1 |
| Q34457131 | A chemiosmotic mechanism of symport |
| Q36856323 | A comparative electron paramagnetic resonance study of the nucleotide-binding domains' catalytic cycle in the assembled maltose ATP-binding cassette importer. |
| Q38424508 | A comparative study of structures and structural transitions of secondary transporters with the LeuT fold |
| Q42661799 | A promiscuous conformational switch in the secondary multidrug transporter MdfA. |
| Q30396233 | Algorithm for selection of optimized EPR distance restraints for de novo protein structure determination |
| Q33757706 | An Asymmetric Conformational Change in LacY. |
| Q35182861 | An early event in the transport mechanism of LacY protein: interaction between helices V and I. |
| Q36398048 | Apo-intermediate in the transport cycle of lactose permease (LacY) |
| Q91814922 | Arg302 governs the pKa of Glu325 in LacY |
| Q43094603 | Backbone structure of transmembrane domain IX of the Na+/proline transporter PutP of Escherichia coli. |
| Q37702858 | Biogenesis of bacterial inner-membrane proteins |
| Q34981065 | CW-EPR studies revealed different motional properties and oligomeric states of the integrin β1a transmembrane domain in detergent micelles or liposomes |
| Q29615329 | Carbon catabolite repression in bacteria: many ways to make the most out of nutrients |
| Q24657493 | Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models |
| Q28565826 | Charge-to-substrate ratio during organic cation uptake by rat OCT2 is voltage dependent and altered by exchange of glutamate 448 with glutamine |
| Q42148894 | Clogging the periplasmic pathway in LacY. |
| Q51367033 | Coarse-grained simulations of proton-dependent conformational changes in lactose permease. |
| Q42067379 | Comparative stability of Major Facilitator Superfamily transport proteins |
| Q34384175 | Conformational cycle and ion-coupling mechanism of the Na+/hydantoin transporter Mhp1. |
| Q36589222 | Conformational ensemble of the sodium-coupled aspartate transporter |
| Q57842680 | Crystal Structure of a ligand-bound LacY-Nanobody Complex |
| Q37398102 | Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation |
| Q27677132 | Crystal structure of a eukaryotic phosphate transporter |
| Q27667891 | Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition |
| Q43199561 | Defining topological features of membrane proteins by nanoelectrospray ionisation mass spectrometry |
| Q38343096 | Delineating electrogenic reactions during lactose/H+ symport |
| Q94541260 | Diversity in kinetics correlated with structure in nano body-stabilized LacY |
| Q41970720 | Electron spin resonance shows common structural features for different classes of EcoRI-DNA complexes |
| Q37164425 | Electrophysiological characterization of LacY. |
| Q28080486 | Energy coupling mechanisms of MFS transporters |
| Q93380101 | Engineered occluded apo-intermediate of LacY |
| Q35849805 | Evidence for an intermediate conformational state of LacY. |
| Q47996335 | Exploration of conformational changes in lactose permease upon sugar binding and proton transfer through coarse-grained simulations |
| Q41897040 | Flexible gates generate occluded intermediates in the transport cycle of LacY. |
| Q58885503 | Function, Structure, and Evolution of the Major Facilitator Superfamily: The LacY Manifesto |
| Q34405201 | Functional architecture of MFS D-glucose transporters |
| Q38736693 | Galactoside-binding site in LacY. |
| Q43139307 | Gating topology of the proton-coupled oligopeptide symporters |
| Q38347546 | Helix dynamics in LacY: helices II and IV |
| Q27684026 | High-resolution crystal structure of spin labelled (T21R1) azurin from Pseudomonas aeruginosa: a challenging structural benchmark for in silico spin labelling algorithms |
| Q36762583 | Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2. |
| Q37653308 | Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch. |
| Q41908452 | Improved Sensitivity for Long-Distance Measurements in Biomolecules: Five-Pulse Double Electron-Electron Resonance. |
| Q33767717 | Increased sensitivity and extended range of distance measurements in spin-labeled membrane proteins: Q-band double electron-electron resonance and nanoscale bilayers |
| Q37184646 | Ins and outs of major facilitator superfamily antiporters. |
| Q64270553 | Insertion and folding pathways of single membrane proteins guided by translocases and insertases |
| Q63387646 | Interpretation of spectroscopic data using molecular simulations for the secondary active transporter BetP |
| Q34121740 | Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. |
| Q24338112 | Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin |
| Q24630374 | Lactose permease and the alternating access mechanism |
| Q36785076 | Mechanism for alternating access in neurotransmitter transporters |
| Q38456985 | Metabolic Regulation of a Bacterial Cell System with Emphasis on Escherichia coli Metabolism |
| Q27681921 | Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1 |
| Q38165142 | Monocarboxylic acid transport |
| Q37590328 | Multicomponent drug efflux complexes: architecture and mechanism of assembly |
| Q37391160 | Multifrequency electron spin resonance spectra of a spin-labeled protein calculated from molecular dynamics simulations |
| Q37322013 | Neisseria gonorrhoeae Crippled Its Peptidoglycan Fragment Permease To Facilitate Toxic Peptidoglycan Monomer Release |
| Q36499114 | Opening and closing of the periplasmic gate in lactose permease |
| Q34213970 | Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding |
| Q34831958 | Outward-facing conformers of LacY stabilized by nanobodies |
| Q52336563 | Oversized galactosides as a probe for conformational dynamics in LacY. |
| Q33564783 | Probing of the rates of alternating access in LacY with Trp fluorescence |
| Q30492887 | Probing the (H3-H4)2 histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling |
| Q34311475 | Probing the periplasmic-open state of lactose permease in response to sugar binding and proton translocation |
| Q92995166 | Probing the solution structure of the E. coli multidrug transporter MdfA using DEER distance measurements with nitroxide and Gd(III) spin labels |
| Q38350971 | Properties of a LacY efflux mutant |
| Q36392970 | Proton-coupled dynamics in lactose permease |
| Q34493075 | Protonation and sugar binding to LacY. |
| Q36567205 | Protonation drives the conformational switch in the multidrug transporter LmrP. |
| Q33767467 | Real-time conformational changes in LacY. |
| Q43142319 | Reassessment of models of facilitated transport and cotransport |
| Q38350170 | Residues gating the periplasmic pathway of LacY. |
| Q38351323 | Residues in the H+ translocation site define the pKa for sugar binding to LacY. |
| Q33757749 | Role of Conserved Gly-Gly Pairs on the Periplasmic Side of LacY. |
| Q36342663 | Role of protons in sugar binding to LacY |
| Q36140695 | Role of the irreplaceable residues in the LacY alternating access mechanism |
| Q35949089 | Simulations of substrate transport in the multidrug transporter EmrD |
| Q39921824 | Single and double nitroxide labeled bis(terpyridine)-copper(II): influence of orientation selectivity and multispin effects on PELDOR and RIDME. |
| Q33927361 | Single residue within the antigen translocation complex TAP controls the epitope repertoire by stabilizing a receptive conformation |
| Q41962372 | Site-directed alkylation studies with LacY provide evidence for the alternating access model of transport |
| Q27648335 | Structural determination of wild-type lactose permease |
| Q27655050 | Structural origin of weakly ordered nitroxide motion in spin-labeled proteins |
| Q37374599 | Structure and pH-induced structural rearrangements of the putative multidrug efflux pump EmrD in liposomes probed by site-directed spin labeling. |
| Q35895547 | Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site |
| Q27681433 | Structure of sugar-bound LacY |
| Q27679695 | Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A |
| Q28580055 | Studies on the DIDS-binding site of monocarboxylate transporter 1 suggest a homology model of the open conformation and a plausible translocation cycle |
| Q51283968 | Substrate transport pathway inside outward open conformation of EmrD: a molecular dynamics simulation study. |
| Q30361148 | Substrate-induced changes in the structural properties of LacY |
| Q34006394 | Sugar binding induces the same global conformational change in purified LacY as in the native bacterial membrane |
| Q42856974 | Symmetry-constrained analysis of pulsed double electron-electron resonance (DEER) spectroscopy reveals the dynamic nature of the KcsA activation gate. |
| Q41912596 | The Cys154-->Gly mutation in LacY causes constitutive opening of the hydrophilic periplasmic pathway |
| Q38249975 | The Structure and Function of OxlT, the Oxalate Transporter of Oxalobacter formigenes |
| Q37821357 | The alternating access transport mechanism in LacY. |
| Q35581686 | The mechanism of substrate release by the aspartate transporter GltPh: insights from simulations |
| Q38259383 | The periplasmic cavity of LacY mutant Cys154→Gly: how open is open? |
| Q35016767 | The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters. |
| Q38394090 | The sodium/multivitamin transporter: a multipotent system with therapeutic implications. |
| Q30409391 | Toward the fourth dimension of membrane protein structure: insight into dynamics from spin-labeling EPR spectroscopy |
| Q36300238 | Transient conformers of LacY are trapped by nanobodies |
| Q37069777 | Trivalent arsenicals and glucose use different translocation pathways in mammalian GLUT1 |
| Q36895867 | Trp replacements for tightly interacting Gly-Gly pairs in LacY stabilize an outward-facing conformation |
| Q38259553 | Understanding transporter specificity and the discrete appearance of channel-like gating domains in transporters |
| Q28817897 | Uniporter substrate binding and transport: reformulating mechanistic questions |
| Q58698722 | Uptake dynamics in the Lactose permease (LacY) membrane protein transporter |
| Q37348184 | YidC assists the stepwise and stochastic folding of membrane proteins |
| Q36604907 | Zinc drives a tertiary fold in the prion protein with familial disease mutation sites at the interface |
| Q34528343 | pH Regulation of Electrogenic Sugar/H+ Symport in MFS Sugar Permeases |
| Q41997297 | pKa of Glu325 in LacY. |
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