Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic α2A-adrenergic receptor

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Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic α2A-adrenergic receptor is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...863622W
P356DOI10.1371/JOURNAL.PONE.0063622
P8608Fatcat IDrelease_muhp4wytjzemxcwmep4a4a4qym
P932PMC publication ID3653853
P698PubMed publication ID23691077
P5875ResearchGate publication ID236925251

P2093author name stringYuan Wang
Yanping Wang
Hongmei Li
Xiaohui Yu
Huadong Wang
Daxiang Lu
Faqiang Wang
Xiuxiu Lv
Yiyang Wang
P2860cites workEffects of yohimbine and desipramine on adrenal catecholamine release in response to splanchnic nerve stimulation in anesthetized dogs.Q51594580
Tumor necrosis factor-alpha-induced caspase activation mediates endotoxin-related cardiac dysfunction.Q53856998
Phagocyte-derived catecholamines enhance acute inflammatory injuryQ59082332
In Vivo Expression of Proinflammatory Mediators in the Adult Heart after Endotoxin Administration: The Role of Toll‐Like Receptor–4Q59192150
Ventricular Myocyte Caspases Are Directly Responsible for Endotoxin-Induced Cardiac DysfunctionQ59607584
Endotoxin infusion in rats induces apoptotic and survival pathways in heartsQ73112674
Gut-derived norepinephrine plays a critical role in producing hepatocellular dysfunction during early sepsisQ73230238
Activated macrophages decrease rat cardiac myocyte contractility: importance of ICAM-1-dependent adhesionQ78009283
Effects of neutral sulfate berberine on LPS-induced cardiomyocyte TNF-alpha secretion, abnormal calcium cycling, and cardiac dysfunction in ratsQ82260254
Depletion and recovery of catecholamines in several organs of rats treated with reserpineQ83839148
Antagonism of alpha2A-adrenoceptor: a novel approach to inhibit inflammatory responses in sepsisQ28583909
Myocardial dysfunction in sepsis: a large, unsolved puzzleQ33353302
Pivotal role of the alpha(2A)-adrenoceptor in producing inflammation and organ injury in a rat model of sepsisQ33442838
Dose-dependent effects of endotoxin on neurobehavioral functions in humansQ34099178
Isoproterenol inhibits bacterial lipopolysaccharide-stimulated release of tumor necrosis factor-alpha from human heart tissueQ34191358
The cell in shock: the origin of multiple organ failureQ36405865
Sepsis and the heart.Q36910137
alpha(2)-Adrenoceptor subtypes-mediated physiological, pharmacological actionsQ37499245
Nitric oxide and calcium signaling regulate myocardial tumor necrosis factor-α expression and cardiac function in sepsisQ37710978
The paradox of α-adrenergic coronary vasoconstriction revisitedQ37860513
Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor.Q38339453
alpha- and beta-adrenergic pathways differentially regulate cell type-specific apoptosis in rat cardiac myocytesQ40941082
Contractile response of norepinephrine is modulated by caspase-3 in adult rat ventricular myocytes isolated from septic rat heartQ42541107
Sepsis: new insights into its pathogenesis and treatmentQ44043307
Sepsis causes presynaptic histamine H3 and alpha2-adrenergic dysfunction in canine myocardiumQ44189218
Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemiaQ44214210
Stimulation of interleukin-12 production in mouse macrophages via activation of p38 mitogen-activated protein kinase by α2-adrenoceptor agonistsQ44410779
Pretreatment with Berberine and Yohimbine Protects Against LPS-Induced Myocardial Dysfunction Via Inhibition of Cardiac I-κBα Phosphorylation and Apoptosis in MiceQ44914649
Cytokine-induced nitric oxide inhibits mitochondrial energy production and induces myocardial dysfunction in endotoxin-treated rat heartsQ45046490
Intracoronary alpha 2-adrenergic receptor blockade attenuates ischemia in conscious dogs during exerciseQ46129955
Berberine inhibits cytosolic phospholipase A2 and protects against LPS-induced lung injury and lethality independent of the alpha2-adrenergic receptor in miceQ46643297
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)e63622
P577publication date2013-05-14
P1433published inPLOS OneQ564954
P1476titleYohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic α2A-adrenergic receptor
P478volume8

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cites work (P2860)
Q95840784A Bitter Taste in Your Heart
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Q55339088α2A-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation.
Q35247702β₁-adrenoceptor stimulation promotes LPS-induced cardiomyocyte apoptosis through activating PKA and enhancing CaMKII and IκBα phosphorylation

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