Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor

scientific article

Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/CB500677X
P932PMC publication ID4273976
P698PubMed publication ID25268696

P50authorPeter D. MaceQ42423701
Bernhard C LechtenbergQ81790787
P2093author name stringElena B Pasquale
Stefan J Riedl
Philip E Dawson
Ilaria Lamberto
Erika J Olson
P2860cites workMolProbity: all-atom structure validation for macromolecular crystallographyQ24649111
EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in miceQ27320846
Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 ReceptorQ27651657
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin SignalingQ27657815
Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding PromiscuityQ27658020
Structurally encoded intraclass differences in EphA clusters drive distinct cell responsesQ27678839
Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5Q27679723
Overview of the CCP4 suite and current developmentsQ27860782
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLMQ27861099
Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transportQ28251532
A quantitative analysis of kinase inhibitor selectivityQ28264038
The future of peptide-based drugsQ28281702
Regeneration-enhancing effects of EphA4 blocking peptide following corticospinal tract injury in adult rat spinal cordQ28584025
EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomersQ29347252
Anatomy of hot spots in protein interfacesQ29616238
Eph-ephrin bidirectional signaling in physiology and diseaseQ29617975
Eph receptor signalling casts a wide net on cell behaviourQ29619988
Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide gene-expression profiles of prostate cancers and PINsQ31108703
Discovery and characterization of a novel cyclic peptide that effectively inhibits ephrin binding to the EphA4 receptor and displays anti-angiogenesis activityQ31144324
EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growthQ33257109
Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's diseaseQ33919522
Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.Q33953835
Eph receptors and ephrins in cancer: bidirectional signalling and beyondQ34021365
Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.Q34026097
Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulationsQ34141080
Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformationsQ34170551
HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discoveryQ34564346
Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasionQ36223133
Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptorQ36914295
Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in ratsQ36947648
RNAi screen for rapid therapeutic target identification in leukemia patientsQ37187716
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transportQ37579588
Targeting Eph receptors with peptides and small molecules: progress and challengesQ37951723
Eph receptors at synapses: implications in neurodegenerative diseases.Q37961534
Therapeutic perspectives of Eph-ephrin system modulation.Q38167588
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humansQ38322311
MicroRNA-10a is involved in the metastatic process by regulating Eph tyrosine kinase receptor A4-mediated epithelial-mesenchymal transition and adhesion in hepatoma cellsQ39274635
Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteasesQ39567597
Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers.Q39932205
EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell lineQ39940130
Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptorsQ41875227
EphA4 signaling in juveniles establishes topographic specificity of structural plasticity in the hippocampusQ43133200
Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signalingQ44259200
Modifying expression of EphA4 and its downstream targets improves functional recovery after strokeQ44310626
Targeting the EphA4 receptor in the nervous system with biologically active peptidesQ44707568
EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactionsQ46915994
P433issue12
P304page(s)2787-2795
P577publication date2014-10-14
P1433published inACS Chemical BiologyQ165583
P1476titleDevelopment and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptor
P478volume9

Reverse relations

cites work (P2860)
Q90250053Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling
Q60933281EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions
Q49709391EphB4: A promising target for upper aerodigestive malignancies
Q35634594High-Throughput Screening by Nuclear Magnetic Resonance (HTS by NMR) for the Identification of PPIs Antagonists
Q33882055Identification and characterization of Nanobodies targeting the EphA4 receptor.
Q41063994Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability
Q55367685Modulatory Effects of a Novel Cyclized Peptide in Reducing the Expression of Markers Linked to Alzheimer's Disease.
Q46499375Potent and Selective EphA4 Agonists for the Treatment of ALS.
Q46167371SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration
Q30398451Targeting kinase signaling pathways with constrained peptide scaffolds
Q26799461Targeting the Eph System with Peptides and Peptide Conjugates
Q51503040The Role of EphA4 Signaling in Radiation-Induced EMT-Like Phenotype in Colorectal Cancer Cells.
Q57812327Therapeutic potential of targeting the Eph/ephrin signaling complex

Search more.