DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

scientific article

DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/TOXSCI/KFU207
P932PMC publication ID4274381
P698PubMed publication ID25288669
P5875ResearchGate publication ID266624238

P50authorSara Ortega AtienzaQ60058080
P2093author name stringMichal W Luczak
Anatoly Zhitkovich
Zachary DeLoughery
P2860cites workAscorbate is the principal reductant of chromium (VI) in rat liver and kidney ultrafiltratesQ67975160
Reduction of hexavalent chromium by ascorbic acid and glutathione with special reference to the rat lungQ68857566
Reaction of chromium(VI) with ascorbate produces chromium(V), chromium(IV), and carbon-based radicalsQ72492310
Cellular vitamin C increases chromate toxicity via a death program requiring mismatch repair but not p53Q79775621
Hexavalent chromium and lung cancer in the chromate industry: a quantitative risk assessmentQ23920347
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage responseQ24299489
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSαQ24339204
Postreplicative mismatch repairQ27690911
ATM phosphorylates histone H2AX in response to DNA double-strand breaksQ28188651
Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromiumQ28255368
Regulation of DNA double-strand break repair pathway choiceQ28262730
Genomic instability in mice lacking histone H2AXQ28589826
Double strand break repair functions of histone H2AXQ28661754
Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair.Q30524137
gammaH2AX foci form preferentially in euchromatin after ionising-radiation.Q33303665
Monitoring Cr intermediates and reactive oxygen species with fluorescent probes during chromate reductionQ33637092
Mechanism of DNA-protein cross-linking by chromiumQ33653854
Mismatch repair proteins are activators of toxic responses to chromium-DNA damageQ33758325
Double-strand break repair: 53BP1 comes into focusQ34391068
DNA double-strand break repair: all's well that ends wellQ34555274
WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adductsQ35580739
Vitamin C: basic metabolism and its function as an index of oxidative stressQ35743610
Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levelsQ36055967
Mouse centric and pericentric satellite repeats form distinct functional heterochromatinQ36322196
Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaksQ36528173
DNA damage-induced cell death by apoptosis.Q36561337
The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damageQ37256608
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenanceQ37942059
Histone modifications for human epigenome analysisQ38112246
Systematic identification of functional residues in mammalian histone H2AXQ39251706
Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimersQ39464747
Causes of DNA single-strand breaks during reduction of chromate by glutathione in vitro and in cellsQ40276804
Human nucleotide excision repair efficiently removes chromium-DNA phosphate adducts and protects cells against chromate toxicityQ40566148
Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin.Q40615478
Differential effects of chromium(VI) on constitutive and inducible gene expression in chick embryo liver in vivo and correlation with chromium(VI)-induced DNA damageQ42496016
Ascorbate acts as a highly potent inducer of chromate mutagenesis and clastogenesis: linkage to DNA breaks in G2 phase by mismatch repairQ42949332
Carcinogenic chromium(VI) induces cross-linking of vitamin C to DNA in vitro and in human lung A549 cellsQ43894612
Generation of S phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of gamma-H2AX.Q45000379
Glutathione and free amino acids form stable complexes with DNA following exposure of intact mammalian cells to chromate.Q53464761
P433issue1
P921main subjectphosphorylationQ242736
euchromatinQ910324
protein ubiquitinationQ3547638
P304page(s)54-63
P577publication date2014-10-06
P1433published inToxicological SciencesQ2446966
P1476titleDNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination
P478volume143

Reverse relations

cites work (P2860)
Q3367759320S immunoproteasomes remove formaldehyde-damaged cytoplasmic proteins suppressing caspase-independent cell death
Q36456197Different ATM Signaling in Response to Chromium(VI) Metabolism via Ascorbate and Nonascorbate Reduction: Implications for in Vitro Models and Toxicogenomics
Q33569518Environmental exposure to arsenic and chromium in an industrial area
Q28395858Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells
Q64389270Monoubiquitinated γ-H2AX: Abundant product and specific biomarker for non-apoptotic DNA double-strand breaks
Q38701982Nickel-induced HIF-1α promotes growth arrest and senescence in normal human cells but lacks toxic effects in transformed cells
Q47134376Residual γH2AX foci induced by low dose x-ray radiation in bone marrow mesenchymal stem cells do not cause accelerated senescence in the progeny of irradiated cells
Q58700484Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks
Q58606129Toxicological Antagonism among Welding Fume Metals: Inactivation of Soluble Cr(VI) by Iron
Q41705208Variation in Extracellular Detoxification Is a Link to Different Carcinogenicity among Chromates in Rodent and Human Lungs
Q64387425Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin

Search more.