Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells

scientific article

Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.6866
P932PMC publication ID4891014
P698PubMed publication ID26760771
P5875ResearchGate publication ID290432671

P50authorZbyszek DarzynkiewiczQ33103772
Hong ZhaoQ77639007
P2093author name stringSoyoung Park
Dazhong Xu
Cen Li
P2860cites workGene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent streQ22253460
Molecular mechanisms of Cr(VI)-induced carcinogenesisQ23918459
Nitric oxide-mediated Bcl-2 stabilization potentiates malignant transformation of human lung epithelial cellsQ23918831
Mechanisms of Cr(VI) induced p53 activation: the role of phosphorylation, mdm2 and ERKQ23922086
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interfaceQ24301761
The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activityQ24314999
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatmentQ24338426
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsQ24608343
Genomic and proteomic profiling of responses to toxic metals in human lung cellsQ24814797
Evidence that MIG-6 is a tumor-suppressor geneQ28250282
Genomic instability--an evolving hallmark of cancerQ28274009
Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF functionQ28294466
The DNA-dependent protein kinaseQ28373950
Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance developmentQ28386290
Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signalingQ28387227
Assessment of Cr(VI)-induced cytotoxicity and genotoxicity using high content analysisQ28387269
NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromiumQ28392194
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formationQ28590384
Long-term exposure to low-concentrations of Cr(VI) induce DNA damage and disrupt the transcriptional response to benzo[a]pyreneQ28658104
Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell lineQ28742638
GammaH2AX and cancerQ29614974
Lung cancerQ29615473
Regulating the p53 pathway: in vitro hypotheses, in vivo veritasQ29615658
microRNA-148a is a prognostic oncomiR that targets MIG6 and BIM to regulate EGFR and apoptosis in glioblastomaQ30407637
Cytometric analysis of DNA damage: phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs).Q33432971
Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmiumQ33835721
Comparison of gene expression profiles in chromate transformed BEAS-2B cellsQ33855548
Mig-6 controls EGFR trafficking and suppresses gliomagenesisQ33859568
ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells.Q34049864
EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4.Q34109344
Mechanism of action of camptothecinQ34149055
DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.Q34760238
Monoubiquitination of H2AX protein regulates DNA damage response signalingQ35150282
Environmental epigenetics in metal exposureQ35592179
Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanismsQ35595461
Toxicity and carcinogenicity of chromium compounds in humansQ36493576
Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasisQ36852720
Regulation of DNA repair throughout the cell cycleQ37088926
Carcinogenicity of hexavalent chromium.Q37357620
Proteasome inhibitors: an expanding army attacking a unique targetQ37979388
Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposuresQ38244952
The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitorsQ38994746
Differential responses to genotoxic agents between induced pluripotent stem cells and tumor cell linesQ39053392
Regulation of EGFR trafficking and cell signaling by Sprouty2 and MIG6 in lung cancer cellsQ39123581
The mitogen-inducible gene-6 is involved in regulation of cellular senescence in normal diploid fibroblastsQ39142664
Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimersQ39464747
Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signalingQ39510460
Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability.Q39823708
Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growthQ40358363
Phosphorylation of histone H2AX at M phase in human cells without DNA damage responseQ40375352
Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinaseQ40401323
A two-tiered mechanism of EGFR inhibition by RALT/MIG6 via kinase suppression and receptor degradation.Q40464017
Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling.Q41491151
ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosisQ46903679
Lung cancer among workers in chromium chemical productionQ47667127
Cytokinesis-block micronucleus cytome assay.Q53548886
Genotoxic ability of cadmium, chromium and nickel salts studied by kinetochore staining in the cytokinesis-blocked micronucleus assayQ73849817
Genomewide loss of heterozygosity and its clinical associations in non small cell lung cancerQ81757968
P433issue8
P407language of work or nameEnglishQ1860
P921main subjecthexavalent chromiumQ2660666
DNA damageQ5205747
P304page(s)8916-30
P577publication date2016-02-23
P1433published inOncotargetQ1573155
P1476titleGene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells
P478volume7

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cites work (P2860)
Q37633880Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species.
Q47888526Mutual regulation between Polo-like kinase 3 and SIAH2 E3 ubiquitin ligase defines a regulatory network that fine-tunes the cellular response to hypoxia and nickel
Q38607684Nuclear Gene 33/Mig6 Regulates the DNA Damage Response through an ATM-dependent Mechanism
Q38688209Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells

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