Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development

scientific article

Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M114.619783
P3181OpenCitations bibliographic resource ID4778750
P932PMC publication ID4303672
P698PubMed publication ID25477514

P50authorYoung-Ok SonQ39505078
Xianglin ShiQ57164086
Zhuo ZhangQ66746152
Poyil PratheeshkumarQ113020041
P2093author name stringLei Wang
Kazuya Kondo
Jin Dai
Hua Yao
Donghern Kim
Leonard Yenwong Fai
P2860cites workThe Hallmarks of CancerQ221226
Multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of Cr(VI)-transformed lung cellsQ23912143
Cell apoptosis induced by carcinogenic metalsQ23912827
Role of reactive oxygen species and p53 in chromium(VI)-induced apoptosisQ23914865
Metal-induced oxidative stress and signal transductionQ23921762
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Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor SensitivityQ27644014
Untangling the ErbB signalling networkQ27860884
Mechanisms and Functions of Cell DeathQ28261655
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathwaysQ28274882
NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromiumQ28392194
Lung inflammation, injury, and proliferative response after repetitive particulate hexavalent chromium exposureQ28392910
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismQ29547302
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?Q29616804
Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cellsQ33601934
Apoptosis and carcinogenesisQ33722362
EGF receptor ligandsQ34185050
Lung Adenocarcinoma From East Asian Never-Smokers Is a Disease Largely Defined by Targetable Oncogenic Mutant KinasesQ34281228
One hundred years of chromium and cancer: a review of epidemiological evidence and selected case reportsQ34372671
Redox regulation of protein kinasesQ35174581
Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.Q35553145
Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancerQ35671213
The biology of epidermal growth factor receptor in lung cancerQ35817506
BCL2 family in DNA damage and cell cycle controlQ36501194
NADPH oxidase biology and the regulation of tyrosine kinase receptor signaling and cancer drug cytotoxicityQ36656128
Protein tyrosine phosphorylation and reversible oxidation: two cross-talking posttranslation modificationsQ36658117
EGFR kinase domain mutations - functional impact and relevance for lung cancer therapyQ36758325
Reflections on hexavalent chromium: health hazards of an industrial heavyweightQ36916771
Oxidative stress and chromium(VI) carcinogenesisQ37186767
The epidermal growth factor receptor ligands at a glanceQ37324458
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.Q37396608
EGFR mutations and lung cancerQ37795807
Anti-apoptosis and cell survival: A reviewQ37802459
The impact of reactive oxygen species on anticancer therapeutic strategiesQ38178931
Targeting PI3K/AKT/mTOR pathway in non small cell lung cancerQ38215087
Hexavalent chromium induced ROS formation, Akt, NF-kappaB, and MAPK activation, and TNF-alpha and IL-1alpha production in keratinocytes.Q39682219
NADPH oxidase NOX1 controls autocrine growth of liver tumor cells through up-regulation of the epidermal growth factor receptor pathwayQ39696544
Human bronchial epithelial cells malignantly transformed by hexavalent chromium exhibit an aneuploid phenotype but no microsatellite instability.Q39823708
Magnolol induces apoptosis via inhibiting the EGFR/PI3K/Akt signaling pathway in human prostate cancer cellsQ39881796
AKT/mTOR pathway activation and BCL-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001.Q39882008
Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21-/- HCT116 colon cancer cellsQ40048856
Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cellsQ40268108
Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factorQ40550725
Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.Q40831748
Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agentsQ41077480
Chromium (V) and hydroxyl radical formation during the glutathione reductase-catalyzed reduction of chromium (VI).Q45007062
Reactive oxygen species generation is involved in epidermal growth factor receptor transactivation through the transient oxidization of Src homology 2-containing tyrosine phosphatase in endothelin-1 signaling pathway in rat cardiac fibroblasts.Q46878031
Chromium, nickel and weldingQ68590339
Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survivalQ73755005
UVB-induced epidermal growth factor receptor phosphorylation is critical for downstream signaling and keratinocyte survivalQ74057136
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
reactive oxygen speciesQ424361
P304page(s)2213-24
P577publication date2015-01-23
P1433published inJournal of Biological ChemistryQ867727
P1476titleConstitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development
P478volume290

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cites work (P2860)
Q42395477Activation of Epidermal Growth Factor Receptor/p38/Hypoxia-inducible Factor-1α Is Pivotal for Angiogenesis and Tumorigenesis of Malignantly Transformed Cells Induced by Hexavalent Chromium
Q89819617Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and the Bcl-2 Protein Family
Q47655080Comparative Proteomics of Chromium-Transformed Beas-2B Cells by 2D-DIGE and MALDI-TOF/TOF MS.
Q38754943Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells
Q50069776Dual Roles of Oxidative Stress in Metal Carcinogenesis
Q28395858Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells
Q37588264Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling
Q91921588Investigating the Role of Mitochondrial Respiratory Dysfunction during Hexavalent Chromium-Induced Lung Carcinogenesis
Q38700019Loss of fructose-1,6-bisphosphatase induces glycolysis and promotes apoptosis resistance of cancer stem-like cells: an important role in hexavalent chromium-induced carcinogenesis
Q40592148Oral pathogens change proliferation properties of oral tumor cells by affecting gene expression of human defensins
Q28388934Progress and prospects of reactive oxygen species in metal carcinogenesis
Q90161291Reduced EGFR Level in eIF2α PhosphorylationDeficient Hepatocytes Is Responsible for Susceptibility to Oxidative Stress
Q28392048The impact of oil spill to lung health--Insights from an RNA-seq study of human airway epithelial cells

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