Activation of Epidermal Growth Factor Receptor/p38/Hypoxia-inducible Factor-1α Is Pivotal for Angiogenesis and Tumorigenesis of Malignantly Transformed Cells Induced by Hexavalent Chromium

scientific article published on 25 May 2016

Activation of Epidermal Growth Factor Receptor/p38/Hypoxia-inducible Factor-1α Is Pivotal for Angiogenesis and Tumorigenesis of Malignantly Transformed Cells Induced by Hexavalent Chromium is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

External links are
P356DOI10.1074/JBC.M116.715797
P932PMC publication ID4965575
P698PubMed publication ID27226640

P50authorPoyil PratheeshkumarQ113020041
Young-Ok SonQ39505078
Xianglin ShiQ57164086
Zhuo ZhangQ66746152
P2093author name stringJia Luo
Lei Wang
Mei Xu
Kazuya Kondo
Jin Dai
Donghern Kim
Youn-Hee Park
Leonard Yenwong Fai
P2860cites workMiRNA-directed regulation of VEGF and other angiogenic factors under hypoxiaQ21092263
p38 signaling-mediated hypoxia-inducible factor 1 alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cellsQ23918912
Characterization of the structure and function of a novel MAP kinase kinase (MKK6)Q24336966
Targeting HIF-1 for cancer therapyQ27860504
Tumor angiogenesis: therapeutic implicationsQ27860595
Angiogenesis in cancer and other diseasesQ27861015
Re-Treatment with EGFR-TKIs in NSCLC Patients Who Developed Acquired ResistanceQ28083239
Aspirin inhibits matrix metalloproteinase-2 activity, increases E-cadherin production, and inhibits in vitro invasion of tumor cellsQ28184976
Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survivalQ28352584
Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance developmentQ28386290
NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromiumQ28392194
Lung inflammation, injury, and proliferative response after repetitive particulate hexavalent chromium exposureQ28392910
The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysisQ28591257
Molecular mechanisms and clinical applications of angiogenesisQ29547314
New functions for the matrix metalloproteinases in cancer progressionQ29547738
Molecular regulation of vessel maturationQ29614540
Angiogenesis as a therapeutic targetQ29619525
Imaging Cells in Three‐Dimensional Collagen MatrixQ33696113
Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesisQ33959044
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expressionQ33968465
MMP-1 expression has an independent prognostic value in breast cancerQ33991012
Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosusQ34051516
One hundred years of chromium and cancer: a review of epidemiological evidence and selected case reportsQ34372671
Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis.Q34457039
Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.Q34618411
Role of microRNAs in vascular diseases, inflammation, and angiogenesisQ34786294
Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian CancerQ35563128
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungsQ35571699
HIFs, hypoxia, and vascular developmentQ35937574
A matrix metalloprotease-PAR1 system regulates vascular integrity, systemic inflammation and death in sepsis.Q36088900
Sulfiredoxin Promotes Colorectal Cancer Cell Invasion and Metastasis through a Novel Mechanism of Enhancing EGFR SignalingQ36386975
Matrix metalloproteinases and tumor metastasisQ36471104
Tissue microarrays of human tumor xenografts: characterization of proteins involved in migration and angiogenesis for applications in the development of targeted anticancer agents.Q36870047
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasisQ37302910
Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancerQ37439490
PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinibQ83364369
Key signalling nodes in mammary gland development and cancer. Mitogen-activated protein kinase signalling in experimental models of breast cancer progression and in mammary gland development.Q37467189
The role of Aurora A in hypoxia-inducible factor 1α-promoting malignant phenotypes of hepatocelluar carcinomaQ37505533
A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesisQ37625140
Tumor angiogenesis and novel antiangiogenic strategiesQ37631002
Profiling of phospho-AKT, phospho-mTOR, phospho-MAPK and EGFR in non-small cell lung cancer.Q37733727
EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanismsQ38314949
Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumptionQ39117478
Epidermal growth factor receptor regulates MT1-MMP and MMP-2 synthesis in SiHa cells via both PI3-K/AKT and MAPK/ERK pathwaysQ39788802
Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21-/- HCT116 colon cancer cellsQ40048856
Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 ActivationQ40106840
Effect of cobalt and chromium ions on MMP-1, TIMP-1, and TNF-alpha gene expression in human U937 macrophages: a role for tyrosine kinasesQ40426031
EGF-induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways.Q40521545
Chapter 2. Chick embryo chorioallantoic membrane models to quantify angiogenesis induced by inflammatory and tumor cells or purified effector moleculesQ41269897
EGF-R regulates MMP function in fibroblasts through MAPK and AP-1 pathways.Q42509418
Epoxygenase-driven angiogenesis in human lung microvascular endothelial cellsQ44185550
Prognostic significance of phosphorylated P38 mitogen-activated protein kinase and HER-2 expression in lymph node-positive breast carcinomaQ44744096
Toxicology and carcinogenesis studies of sodium dichromate dihydrate (Cas No. 7789-12-0) in F344/N rats and B6C3F1 mice (drinking water studies).Q46722870
Expression spectra of matrix metalloproteinases in metastatic non-small cell lung cancer.Q54701090
Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.Q55474987
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotypeQ57517773
BAY 12-9566, a novel inhibitor of matrix metalloproteinases with antiangiogenic activityQ60043732
MicroRNAs modulate the angiogenic properties of HUVECsQ62083234
Invasion of connective tissue by human carcinoma cell lines: requirement for urokinase, urokinase receptor, and interstitial collagenaseQ67867221
Chromium, nickel and weldingQ68590339
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cellsQ74541466
Correlation between expression of the matrix metalloproteinase-1 gene in ovarian cancers and an insertion/deletion polymorphism in its promoter regionQ78257257
High serum levels of matrix metalloproteinase-9 and matrix metalloproteinase-1 are associated with rapid progression in patients with metastatic melanomaQ80404837
P433issue31
P407language of work or nameEnglishQ1860
P921main subjecthexavalent chromiumQ2660666
P304page(s)16271-16281
P577publication date2016-05-25
P1433published inJournal of Biological ChemistryQ867727
P1476titleActivation of Epidermal Growth Factor Receptor/p38/Hypoxia-inducible Factor-1α Is Pivotal for Angiogenesis and Tumorigenesis of Malignantly Transformed Cells Induced by Hexavalent Chromium
P478volume291

Reverse relations

cites work (P2860)
Q38703430A comprehensive review of metal-induced cellular transformation studies
Q47326502ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT.
Q90065402ALDH2 (Aldehyde Dehydrogenase 2) Protects Against Hypoxia-Induced Pulmonary Hypertension
Q58702026Agonist-Biased Signaling via Matrix Metalloproteinase-9 Promotes Extracellular Matrix Remodeling
Q93028280Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats
Q90844748Chromium contributes to human bronchial epithelial cell carcinogenesis by activating Gli2 and inhibiting autophagy
Q33838280Coexpression and expression quantitative trait loci analyses of the angiogenesis gene-gene interaction network in prostate cancer.
Q91330413Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells
Q37407198Cyclooxygenase-2 is associated with malignant phenotypes in human lung cancer
Q47271503FAM198B is Associated with Prolonged Survival and Inhibits Metastasis in Lung Adenocarcinoma via Blockage of ERK-Mediated MMP-1 Expression.
Q91123705Human CCR6+Th17 lymphocytes are highly sensitive to radiation-induced senescence and are a potential target for prevention of radiation-induced toxicity
Q91921588Investigating the Role of Mitochondrial Respiratory Dysfunction during Hexavalent Chromium-Induced Lung Carcinogenesis
Q38682910Long noncoding RNAs: emerging regulators of tumor angiogenesis
Q50862356MicroRNAs: Impaired vasculogenesis in metal induced teratogenicity.
Q92422625Mitochondrial Toxicity of Azithromycin Results in Aerobic Glycolysis and DNA Damage of Human Mammary Epithelia and Fibroblasts
Q92953680Molecular and epigenetic mechanisms of Cr(VI)-induced carcinogenesis
Q46237559New roles for nuclear EGFR in regulating the stability and translation of mRNAs associated with VEGF signaling
Q88141294Oxidative Stress and Metabolic Reprogramming in Cr(VI) Carcinogenesis
Q39007185Regulatory roles of epigenetic modulators, modifiers and mediators in lung cancer
Q91918934Selective activation of tumor-suppressive MAPKP signaling pathway by triptonide effectively inhibits pancreatic cancer cell tumorigenicity and tumor growth
Q92456673Suppression of miR-143 contributes to overexpression of IL-6, HIF-1α and NF-κB p65 in Cr(VI)-induced human exposure and tumor growth
Q47107018Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma
Q90425101Toll-like Receptor 4-Induced Glycolytic Burst in Human Monocyte-Derived Dendritic Cells Results from p38-Dependent Stabilization of HIF-1α and Increased Hexokinase II Expression
Q91314914Toxic effects of Cr(VI) on the bovine hemoglobin and human vascular endothelial cells: Molecular interaction and cell damage
Q36177256Tumor Necrosis Factor-Alpha and the ERK Pathway Drive Chemerin Expression in Response to Hypoxia in Cultured Human Coronary Artery Endothelial Cells
Q88022450Venous component in scar penetrating neovascularisation

Search more.