shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development

scientific article

shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

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P356DOI10.1016/J.STEM.2007.04.001
P698PubMed publication ID18371338
P5875ResearchGate publication ID5481969

P50authorSally TempleQ106559039
P2093author name stringChristopher A Fasano
Ihor R Lemischka
John T Dimos
Natalia B Ivanova
Natalia Lowry
P2860cites workpRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4FQ22254365
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinasesQ24319848
Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancerQ24528253
Cancerous stem cells can arise from pediatric brain tumorsQ24569653
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferationQ24652976
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cellsQ27860717
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferationQ28117650
p21 is a universal inhibitor of cyclin kinasesQ28257305
The regulation of E2F by pRB-family proteinsQ28278789
Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant gliomaQ28287898
Dissecting self-renewal in stem cells with RNA interferenceQ28506922
Transforming growth factor beta 1 promotes cell cycle exit through the cyclin-dependent kinase inhibitor p21 in the developing cerebral cortexQ28566256
RNAi reveals doublecortin is required for radial migration in rat neocortexQ28567912
The timing of cortical neurogenesis is encoded within lineages of individual progenitor cellsQ28588455
TM4: a free, open-source system for microarray data management and analysisQ29547339
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral VectorsQ29547596
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageingQ29615155
Regulation of cerebral cortical size by control of cell cycle exit in neural precursorsQ29615158
Microarray data normalization and transformationQ29617789
Polycomb silencers control cell fate, development and cancerQ29619697
Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomasQ34306873
Polycomb complexes and silencing mechanisms.Q34320981
Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation.Q34426800
Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.Q35208164
Regenerative response in ischemic brain restricted by p21cip1/waf1Q36399429
Searching chromatin for stem cell identityQ36456224
Neuronal expression of regulatory helix-loop-helix factor Id2 gene in mouseQ38314774
Loss of the human polycomb group protein BMI1 promotes cancer-specific cell deathQ39025769
Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice.Q40435177
Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cellsQ40570664
The retinoblastoma protein pathway and the restriction pointQ41239146
The role of transforming growth factor beta in glioma progressionQ41731369
E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cellsQ41902341
p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacityQ42705690
beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous systemQ44472635
Do cells need CDK2 and ... Bcr-Abl?Q44699399
The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cellsQ47605940
Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalonQ48265133
Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cellsQ48950835
Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and agingQ52526599
Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cellsQ73211895
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)87-99
P577publication date2007-06-01
P1433published inCell Stem CellQ2943975
P1476titleshRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development
P478volume1

Reverse relations

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