Origins and clinical implications of the brain tumor stem cell hypothesis

scientific article published on 09 May 2009

Origins and clinical implications of the brain tumor stem cell hypothesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S11060-009-9856-X
P932PMC publication ID2697817
P698PubMed publication ID19430882
P5875ResearchGate publication ID24416451

P50authorAlfredo Quińones- HinojosaQ4723845
P2093author name stringHasan A Zaidi
Thomas Kosztowski
Francesco DiMeco
P2860cites workBmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathwaysQ24529593
Development of NG2 neural progenitor cells requires Olig gene functionQ24546061
Cancerous stem cells can arise from pediatric brain tumorsQ24569653
A genetically tractable model of human glioma formation.Q52542891
Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas.Q53399373
Stem cell marker CD133 affects clinical outcome in glioma patientsQ53507481
p53 suppresses the self-renewal of adult neural stem cellsQ53643375
A specialized vascular niche for adult neural stem cells.Q54237261
Presence of pluripotent CD133+ cells correlates with malignancy of gliomas.Q55465886
CD133 expression and cancer stem cells predict prognosis in high-grade oligodendroglial tumors.Q55466879
Immunohistochemical detection of nestin in pediatric brain tumors.Q55473783
Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.Q55481185
Epidermal growth factor receptor and Ink4a/ArfQ57277079
A Quantitative Assay for the Number of Murine Lymphoma Cells capable of Proliferation in vivoQ59078472
In vitro neuronal production and differentiation by precursor cells derived from the adult human forebrainQ72126631
bFGF regulates the proliferative fate of unipotent (neuronal) and bipotent (neuronal/astroglial) EGF-generated CNS progenitor cellsQ72608792
Neural stem cells in the adult mammalian forebrain: a relatively quiescent subpopulation of subependymal cellsQ72769766
Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cellsQ73407260
Autoradiographic study of degenerative and regenerative proliferation of neuroglia cells with tritiated thymidineQ79333511
Brain tumor stem cellsQ81333017
Targeted molecular therapy of malignant gliomasQ82494790
Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brainQ24600546
An integrated genomic analysis of human glioblastoma multiformeQ24648860
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferationQ24652976
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cellsQ24675176
Prospective identification of tumorigenic breast cancer cellsQ24683474
Glioma stem cells promote radioresistance by preferential activation of the DNA damage responseQ27860541
Identification and expansion of human colon-cancer-initiating cellsQ27860627
Identification of human brain tumour initiating cellsQ27860921
Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellQ27861001
Identification of a cancer stem cell in human brain tumorsQ28131688
Generation of germline-competent induced pluripotent stem cellsQ28131699
High frequency of mutations of the PIK3CA gene in human cancersQ28131776
A cell initiating human acute myeloid leukaemia after transplantation into SCID miceQ28131777
Subventricular zone astrocytes are neural stem cells in the adult mammalian brainQ28137965
Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitroQ28219465
Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastomaQ28236409
Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brainQ28240882
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cellsQ28254370
Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastomaQ28286168
Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous systemQ28292445
The human subventricular zone: a source of new cells and a potential source of brain tumorsQ28299441
Direct isolation of human central nervous system stem cellsQ28318408
CD133 is a marker of bioenergetic stress in human gliomaQ28473995
Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cellsQ28571047
Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cellsQ28585056
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesisQ28592858
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like stateQ29614212
A perivascular niche for brain tumor stem cellsQ29614276
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblastsQ29614794
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageingQ29615155
Long-distance neuronal migration in the adult mammalian brainQ29616114
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinomaQ29620604
Neurogenesis in the adult is involved in the formation of trace memoriesQ29622890
Molecular and cell biology of brain tumor stem cells: lessons from neural progenitor/stem cellsQ33323911
Learning enhances adult neurogenesis in the hippocampal formationQ33858060
Chemical genetics reveals a complex functional ground state of neural stem cellsQ48212220
Expression of the class VI intermediate filament nestin in human central nervous system tumorsQ48427095
The subependymal plate and the genesis of gliomasQ48436571
Fibroblast growth factor‐2/brain‐derived neurotrophic factor—associated maturation of new neurons generated from adult human subependymal cellsQ48470593
Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loopsQ48478557
Expression of neural RNA-binding proteins in the postnatal CNS: implications of their roles in neuronal and glial cell developmentQ48617203
Cell Coupling and Uncoupling in the Ventricular Zone of Developing NeocortexQ48630100
Differential expression of connexins during neocortical development and neuronal circuit formation.Q48723916
Proliferation and differentiation of neuronal stem cells regulated by nerve growth factorQ48876703
Cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesisQ48959027
The importance of implantation site in cerebral carcinogenesis in ratsQ48969355
Chain migration of neuronal precursors.Q49115425
Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cellsQ52165452
Expression of the neural RNA-binding protein Musashi1 in human gliomasQ33941154
Musashi: a translational regulator of cell fate.Q34118649
Somatic stem cell marker prominin-1/CD133 is expressed in embryonic stem cell-derived progenitorsQ34421583
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytomaQ34509145
Development of glial cells in the cerebral wall of ferrets: direct tracing of their transformation from radial glia into astrocytesQ34549279
Gli and hedgehog in cancer: tumours, embryos and stem cells.Q34665999
shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during developmentQ34764944
Stem-cell origin of metastasis and heterogeneity in solid tumoursQ34766180
PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivoQ35080265
Overexpression of c-MYC promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in miceQ35098731
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in miceQ35211546
Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotypeQ36013331
Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumors.Q36205996
Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neuronsQ36323410
Cancer stem cells as mediators of treatment resistance in brain tumors: status and controversiesQ37009796
Neural stem cells confer unique pinwheel architecture to the ventricular surface in neurogenic regions of the adult brainQ37036633
PI3K signaling in glioma--animal models and therapeutic challengesQ37039348
The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memoryQ37120599
Cancer stem cells: markers or biomarkers?Q37147827
Neural stem and progenitor cells in cortical developmentQ37169442
Radial glia give rise to adult neural stem cells in the subventricular zoneQ37713992
The spread of glioblastoma multiforme as a determining factor in the radiation treated volumeQ40020366
Influence of age at inoculation on avian oncornavirus-induced brain tumor incidence, tumor morphology, and postinoculation survival in F344 ratsQ40064640
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.Q40199613
The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomasQ40497319
The stem cell factor-c-kit system and mast cells in human pancreatic cancerQ40690413
Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cellsQ40901854
Co-expression of nestin and vimentin intermediate filaments in invasive human astrocytoma cellsQ40916420
Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors.Q42813095
Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis.Q45213360
Isolation of multipotent neural precursors residing in the cortex of the adult human brain.Q45878110
Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.Q46122787
Genetic determinants of malignancy in a mouse model for oligodendrogliomaQ46129643
Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cellsQ46146255
Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validationQ46549024
Relationship of glioblastoma multiforme to the lateral ventricles predicts survival following tumor resection.Q46610507
The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomasQ47605452
Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cellQ48063176
Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma: correlation of nestin with prognosis of patient survivalQ48152091
NG2-positive cells generate A2B5-positive oligodendrocyte precursor cellsQ48167672
Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursorsQ48196131
Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brainQ48210082
P433issue1
P921main subjectbrain tumorQ233309
neoplastic stem cellsQ1638475
P304page(s)49-60
P577publication date2009-05-09
P13046publication type of scholarly workreview articleQ7318358
P1433published inJournal of Neuro-OncologyQ15752119
P1476titleOrigins and clinical implications of the brain tumor stem cell hypothesis
P478volume93

Reverse relations

cites work (P2860)
Q37365043ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma
Q36678551Cortical Dysplasia: A Possible Substrate for Brain Tumors
Q39459834Cortical and subventricular zone glioblastoma-derived stem-like cells display different molecular profiles and differential in vitro and in vivo properties
Q46061700Hemangioblastomas might derive from neoplastic transformation of neural stem cells/progenitors in the specific niche
Q38071582Impact of Genetic Targets on Primary Brain Tumor Therapy: What’s Ready for Prime Time?
Q37897499MicroRNAs as Regulators of Neural Stem Cell-Related Pathways in Glioblastoma Multiforme
Q38013704Molecular Biology of Glioma
Q26745434Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases
Q36729562Molecular heterogeneity of glioblastomas: does location matter?
Q33684472Mouse models for cancer stem cell research
Q35055311Non-viral gene delivery nanoparticles based on poly(β-amino esters) for treatment of glioblastoma.
Q33729734Primary brain tumors, neural stem cell, and brain tumor cancer cells: where is the link?
Q34786609Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo
Q38311111Prospective therapies for high-grade glial tumours: A literature review
Q34095200Similarity on neural stem cells and brain tumor stem cells in transgenic brain tumor mouse models
Q37758303The Oncogenic Potential of Mesenchymal Stem Cells in the Treatment of Cancer: Directions for Future Research
Q39615612The RhoGAP domain-containing protein, Porf-2, inhibits proliferation and enhances apoptosis in neural stem cells
Q37816878The cancer stem cell hypothesis: failures and pitfalls.
Q34154786Therapy targets in glioblastoma and cancer stem cells: lessons from haematopoietic neoplasms
Q38836817miRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis

Search more.