The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay

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The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1593/NEO.05172
P932PMC publication ID1501282
P698PubMed publication ID16036109
P5875ResearchGate publication ID7709423

P2093author name stringOlivia M Pereira-Smith
Beicheng Sun
Peter J Hornsby
Meizhen Chen
Christina L Hawks
P2860cites workTumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenesQ53374378
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The tumor-suppressive functions of the human INK4A locusQ57187959
Tissue pressures and fluid dynamics in the kidneyQ67782530
Rapid growth of human cancer cells in a mouse model with fibrin clot subrenal capsule assayQ68764151
Mutational analysis defines a minimum level of telomerase activity required for tumourigenic growth of human cellsQ78348098
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)Q24293520
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4aQ24324559
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Identification of specific PP2A complexes involved in human cell transformationQ28248124
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
Improved retroviral vectors for gene transfer and expressionQ29614384
A DNA damage checkpoint response in telomere-initiated senescenceQ29615919
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaksQ30014828
Enumeration of the simian virus 40 early region elements necessary for human cell transformationQ34117528
Cellular senescence as a tumor-protection mechanism: the essential role of countingQ34132858
Telomerase extracurricular activitiesQ34188137
Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblastsQ34286570
Modelling the molecular circuitry of cancerQ34665971
Historical claims and current interpretations of replicative agingQ34713128
Distinct requirements for Ras oncogenesis in human versus mouse cellsQ34787097
Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblastsQ34888948
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.Q35076272
Cancer and ageing: rival demons?Q35118727
Functional genetics and experimental models of human cancerQ35830677
The AMeX method: a multipurpose tissue-processing and paraffin-embedding method. Extraction of protein and application to immunoblottingQ35831236
Normal human fibroblasts are resistant to RAS-induced senescenceQ37012141
Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformationQ37089570
Suppression of tumor growth by senescence in virally transformed human fibroblastsQ37407629
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescenceQ39647398
High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human FibroblastsQ40620874
Immortalization and transformation of primary human airway epithelial cells by gene transfer.Q40722115
Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epitheliumQ40923257
Interactions between adult human prostatic epithelium and rat urogenital sinus mesenchyme in a tissue recombination modelQ42459518
Adrenocortical tissue formed by transplantation of normal clones of bovine adrenocortical cells in scid mice replaces the essential functions of the animals' adrenal glandsQ42796057
Human adrenocortical cell xenotransplantation: model of cotransplantation of human adrenocortical cells and 3T3 cells in scid mice to form vascularized functional tissue and prevent adrenal insufficiencyQ42815388
A genetically tractable model of human glioma formation.Q52542891
Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude miceQ52834188
Progressive loss of malignant behavior in telomerase-negative tumorigenic adrenocortical cells and restoration of tumorigenicity by human telomerase reverse transcriptaseQ53365469
P433issue6
P304page(s)585-593
P577publication date2005-06-01
P1433published inNeoplasiaQ2962042
P1476titleThe minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay
P478volume7

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cites work (P2860)
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