Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models

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Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy models is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0920-1211(02)00076-1
P698PubMed publication ID12151125

P50authorAsla PitkänenQ23039734
P2860cites workFelbamate in experimental model of status epilepticusQ28371394
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Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum.Q42488010
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Felbamate protects CA1 neurons from apoptosis in a gerbil model of global ischemiaQ42555632
Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepamQ42622780
A reversible type of neuronal injury following ischemia in the gerbil hippocampusQ43524490
Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in ratsQ43543021
Tiagabine treatment and DNA damage in rat astrocytes: an in vitro study by comet assay.Q43638388
Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat.Q43716931
Thiopentone and methohexital, but not pentobarbitone, reduce early focal cerebral ischemic injury in ratsQ43730331
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Vigabatrin protects against hippocampal damage but is not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsyQ43774639
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Stimulation-dependent effect of antiepileptic drugs in amygdala kindled rats on both seizure score and duration of afterdischargesQ48096067
Postischemic diazepam is neuroprotective in the gerbil hippocampusQ48120673
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Neuroprotective effect of remacemide hydrochloride in a perforant pathway stimulation model of status epilepticus in the rat.Q48233119
Halothane as a neuroprotectant during constant stimulation of the perforant pathQ48261949
Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindlingQ48275112
Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampusQ48282146
Valproate robustly enhances AP-1 mediated gene expressionQ48305334
PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat.Q48341596
Neuroprotection by delayed administration of topiramate in a rat model of middle cerebral artery embolizationQ48384000
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Effects of lamotrigine and conventional antiepileptic drugs on amygdala- and hippocampal-kindled seizures in ratsQ48406844
Alteration of long-lasting structural and functional effects of kainic acid in the hippocampus by brief treatment with phenobarbitalQ48413498
Comparison of valproate and phenobarbital treatment after status epilepticus in ratsQ48425188
Protective effect of zonisamide, an antiepileptic drug, against transient focal cerebral ischemia with middle cerebral artery occlusion-reperfusion in ratsQ48473716
The Effects of Propofol on Brain Electrical Activity, Neurologic Outcome, and Neuronal Damage Following Incomplete Ischemia in RatsQ48531776
BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsyQ48551095
Lamotrigine protects hippocampal CA1 neurons from ischemic damage after cardiac arrestQ48594740
Tiagabine exerts an anti-epileptogenic effect in amygdala kindling epileptogenesis in the rat.Q48681077
Vigabatrin pre-treatment prevents hilar somatostatin cell loss and the development of interictal spiking activity following sustained simulation of the perforant pathQ48703486
Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cellsQ48704481
Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulinQ48777633
The effect of lamotrigine upon development of cortical kindled seizures in the ratQ48786817
Seizure-induced damage to the hippocampus is prevented by modulation of the GABAergic system.Q48943169
Anticonvulsant drugs selectively affect kindled and penicillin epilepsy, especially during seizure-prone sleep or awakening states in catsQ48947155
Neuroprotective effects of felbamate on global ischaemia in Mongolian gerbilsQ48968065
Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticusQ49050748
The neuroprotective effects of gamma-vinyl GABA in transient global ischemia: a morphological study with early and delayed evaluationsQ49121477
Anticonvulsant effects of zonisamide and phenytoin on seizure activity of the feline visual cortex.Q49155081
Lamotrigine treatment during amygdala-kindled seizure development fails to inhibit seizures and diminishes subsequent anticonvulsant efficacyQ49158046
Risk of unprovoked seizure after acute symptomatic seizure: effect of status epilepticus.Q50852990
Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat.Q51390326
Protective effect of etomidate on kainic acid-induced neurotoxicity in rat hippocampus.Q51399149
Effect of 2,6-diisopropylphenol on the delayed hippocampal cell loss following transient forebrain ischemia in the gerbil.Q51582665
Relationship between the dose-response effects of diazepam and clobazam on electroencephalographic parameters and on kindled amygdaloid seizure activity in rats.Q51766225
Quinolinic acid-induced seizures, but not nerve cell death, are associated with extracellular Ca2+ decrease assessed in the hippocampus by brain dialysis.Q51770926
Effects of clobazam on amygdaloid and hippocampal kindled seizures in rats.Q51790609
The role of epileptic activity in hippocampal and "remote" cerebral lesions induced by kainic acid.Q51875842
A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat.Q52029733
Carbamazepine and carbamazepine-10,11-epoxide inhibit amygdala-kindled seizures in the rat but do not block their development.Q52074613
Failure of carbamazepine to prevent behavioural and histopathological sequels of experimentally induced status epilepticus.Q52202679
Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia.Q52209617
The new antiepileptic drugs lamotrigine and felbamate are effective in phenytoin-resistant kindled rats.Q54045309
Development of a new pharmacological seizure model: effects of anticonvulsants on cortical- and amygdala-kindled seizures in the rat.Q54544637
National General Practice Study of Epilepsy (NGPSE): partial seizure patterns in a general populationQ67561030
Inhibition or enhancement of kindling evolution by antiepilepticsQ68508087
Anticonvulsant and proconvulsant effects of inhibitors of GABA degradation in the amygdala-kindling modelQ69649999
Electroencephalographic burst suppression is not required to elicit maximal neuroprotection from pentobarbital in a rat model of focal cerebral ischemiaQ71158948
Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampusQ71443626
Topiramate: a potent anticonvulsant in the amygdala-kindled ratQ71510432
Vigabatrin and carbamazepine have different efficacies in the prevention of status epilepticus induced neuronal damage in the hippocampus and amygdalaQ71519197
Vigabatrin protects against kainic acid-induced neuronal damage in the rat hippocampusQ71526019
Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral studyQ71625626
Cerebroprotective effect of lamotrigine after focal ischemia in ratsQ72486597
Anticonvulsant activity of PNU-151774E in the amygdala kindled model of complex partial seizuresQ73192026
Different mechanisms of protection against apoptosis by valproate and Li+Q73231420
Protective effect of topiramate against hippocampal neuronal damage after global ischemia in the gerbilsQ73515499
Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrinQ73583786
Usefulness of postischemic thrombolysis with or without neuroprotection in a focal embolic model of cerebral ischemiaQ73742132
Dose-dependent neuroprotection with tiagabine in a focal cerebral ischemia model in ratQ74102484
Neuroprotective activity of tiagabine in a focal embolic model of cerebral ischemiaQ74146473
P433issue1-2
P921main subjectneurodegenerationQ1755122
P304page(s)141-160
P577publication date2002-06-01
P1433published inEpilepsy ResearchQ15746405
P1476titleEfficacy of current antiepileptics to prevent neurodegeneration in epilepsy models
P478volume50

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cites work (P2860)
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