Neuroprotection as a Potential Therapeutic Perspective in Neurodegenerative Diseases: Focus on Antiepileptic Drugs

scientific article published on 31 December 2015

Neuroprotection as a Potential Therapeutic Perspective in Neurodegenerative Diseases: Focus on Antiepileptic Drugs is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1014505840
P356DOI10.1007/S11064-015-1809-5
P8608Fatcat IDrelease_dpse2nc3wzbgreez2o5csg7cze
P698PubMed publication ID26721507

P50authorPaolo CalabresiQ91934184
P2093author name stringF Pisani
C Costa
D Caccamo
L R Pisani
P Mazzocchetti
R Ientile
P2860cites workMitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: Novel therapeutic strategies for neurodegenerative disordersQ21710687
Molecular targets for antiepileptic drug developmentQ24683346
Cellular models to investigate biochemical pathways in Parkinson's diseaseQ26829742
Transgenic animal models for study of the pathogenesis of Huntington's disease and therapyQ26849677
Epigenetic mechanisms of chronic painQ27023688
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevityQ27024064
Animal models of traumatic brain injuryQ27025091
Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigineQ28269848
Oxidative stress in neurodegeneration: cause or consequence?Q28275946
Animal models of ischemic stroke: balancing experimental aims and animal careQ28296165
Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersQ28384232
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1Q28506681
The antiepileptic drug levetiracetam suppresses non-convulsive seizure activity and reduces ischemic brain damage in rats subjected to permanent middle cerebral artery occlusionQ28535091
Coactivation of GABA(A) and GABA(B) receptor results in neuroprotection during in vitro ischemiaQ44730698
Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein inductionQ44930696
Neuroprotective effects of topiramateQ44971031
Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis.Q44989787
Valproic acid inhibits histone deacetylase activity and suppresses excitotoxicity-induced GAPDH nuclear accumulation and apoptotic death in neuronsQ45004321
Possible GABAergic mechanism in the neuroprotective effect of gabapentin and lamotrigine against 3-nitropropionic acid induced neurotoxicityQ45305500
Transient cerebral ischemia increases CA1 pyramidal neuron excitabilityQ45366999
Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neuronsQ28571794
Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylationQ28572236
Alzheimer's diseaseQ29616743
Drug-mediated neuroprotection and antiepileptogenesis: animal dataQ30746341
Mood effects of antiepileptic drugsQ30887496
The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevanceQ33615756
A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizuresQ34155061
Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease.Q34273047
Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate.Q34318938
Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectivesQ34426072
Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational ResearchQ34458158
Neuroprotection by valproic Acid in mouse models of permanent and transient focal cerebral ischemiaQ34554054
Zonisamide improves motor function in Parkinson disease: a randomized, double-blind studyQ34573725
Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition.Q34627485
Efficacy of current antiepileptics to prevent neurodegeneration in epilepsy modelsQ34768832
Migraine prophylaxis, ischemic depolarizations, and stroke outcomes in miceQ34771803
Experimental animal models of intracerebral hemorrhageQ35027677
Zonisamide attenuates α-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's diseaseQ35106629
Antiepileptic drugs as a possible neuroprotective strategy in brain ischemiaQ35143881
Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsyQ35172480
Neuroprotective effects of antiepileptic drugs.Q35179272
Mesenchymal stem cells primed with valproate and lithium robustly migrate to infarcted regions and facilitate recovery in a stroke model.Q35243356
Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's diseaseQ35423803
Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS).Q35589934
Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 miceQ35783263
Bone marrow stem cell mobilization in stroke: a 'bonehead' may be good after all!Q35792838
Classic and new animal models of Parkinson's diseaseQ35875871
Mechanisms of action of antiepileptic drugs.Q36002922
Profile of anticonvulsant activity and neuroprotective effects of novel and potential antiepileptic drugs--an updateQ36355248
Brief update on animal models of hypoxic-ischemic encephalopathy and neonatal strokeQ36359744
Clinical pharmacology and mechanism of action of zonisamideQ36924989
Protective effects of gabapentin on allodynia and alpha 2 delta 1-subunit of voltage-dependent calcium channel in spinal nerve-ligated ratsQ37116880
Phenytoin protects central axons in experimental autoimmune encephalomyelitisQ37165887
Experimental models of status epilepticus and neuronal injury for evaluation of therapeutic interventionsQ37225136
Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia.Q46404080
Lamotrigine attenuates cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits.Q46740558
Preventing effects of a novel anti-parkinsonian agent zonisamide on dopamine quinone formationQ46894064
Tiagabine and vigabatrin reduce the severity of NMDA-induced excitotoxicity in chick retinaQ46898312
The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons.Q46958808
Neuroprotection by lamotrigine in a rat model of neonatal hypoxic-ischaemic encephalopathyQ46980611
Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsyQ47795001
Zonisamide reduces hypoxic-ischemic brain damage in neonatal rats irrespective of its anticonvulsive effectQ48123510
Effects of mood-stabilizing drugs on dendritic outgrowth and synaptic protein levels in primary hippocampal neuronsQ48193624
Neuroprotective effects of valproic acid against hemin toxicity: possible involvement of the down-regulation of heme oxygenase-1 by regulating ubiquitin-proteasomal pathwayQ48220909
Na+/Ca2+ exchanger maintains ionic homeostasis in the peri-infarct area.Q48223619
Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action.Q48235397
Zonisamide reduces nigrostriatal dopaminergic neurodegeneration in a mouse genetic model of Parkinson's diseaseQ48238293
Study of the protective effects of nootropic agents against neuronal damage induced by amyloid-beta (fragment 25-35) in cultured hippocampal neuronsQ48312003
Valproic acid attenuates neuronal loss in the brain of APP/PS1 double transgenic Alzheimer's disease mice modelQ48350023
Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhageQ48425824
In vitro oxygen-glucose deprivation to study ischemic cell death.Q48445138
Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity.Q48473494
Protective effect of zonisamide, an antiepileptic drug, against transient focal cerebral ischemia with middle cerebral artery occlusion-reperfusion in ratsQ48473716
Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemiaQ48598679
In vivo protection of striatal dopaminergic system against 1-methyl-4-phenylpyridinium neurotoxicity by phenobarbitalQ48650335
Valproate improves memory deficits in an Alzheimer's disease mouse model: investigation of possible mechanisms of actionQ48710262
Zonisamide attenuates hyperoxia-induced apoptosis in the developing rat brainQ48721862
Valproic acid alleviates memory deficits and attenuates amyloid-β deposition in transgenic mouse model of Alzheimer's diseaseQ48773223
Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosisQ48837003
Inhibition of excitatory synaptic transmission in hippocampal neurons by levetiracetam involves Zn²⁺-dependent GABA type A receptor-mediated presynaptic modulationQ48858004
Tiagabine prevents seizures, neuronal damage and memory impairment in experimental status epilepticusQ49050748
A critical role of NO/cGMP/PKG dependent pathway in hippocampal post-ischemic LTP: modulation by zonisamideQ49057257
Effects of mood stabilizers on adult dentate gyrus-derived neural precursor cellsQ50441594
Neuroprotective effect of levetiracetam on hypoxic ischemic brain injury in neonatal rats.Q50659873
Age-dependent effects of valproic acid in Alzheimer's disease (AD) mice are associated with nerve growth factor (NGF) regulation.Q50685521
Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin.Q50706209
Neuroprotective, neuroplastic, and neurobehavioral effects of daily treatment with levetiracetam in experimental traumatic brain injury.Q50736416
Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy.Q52024302
Phenobarbital pre-treatment prevents kainic acid-induced impairments in acquisition learning.Q52107500
Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia.Q52209617
Zonisamide attenuates MPP+-induced oxidative toxicity through modulation of Ca2+ signaling and caspase-3 activity in neuronal PC12 cells.Q53130063
Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation.Q53574209
Antioxidant, anticonvulsive and neuroprotective effects of dapsone and phenobarbital against kainic acid-induced damage in rats.Q53789683
Felbamate neuroprotection against CA1 traumatic neuronal injuryQ71377077
Anti-epileptic drugs as possible neuroprotectants in cerebral ischemiaQ73489981
Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissueQ74149576
Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepineQ80678677
Lamotrigine increases the number of BrdU-labeled cells in the rat hippocampusQ82850870
Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in ratsQ83830542
Zonisamide up-regulated the mRNAs encoding astrocytic anti-oxidative and neurotrophic factorsQ84279124
Prospects of levetiracetam as a neuroprotective drug against status epilepticus, traumatic brain injury, and strokeQ37276387
The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brainQ37304728
Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicityQ37341162
Zonisamide: a review of the clinical and experimental evidence for its use in Parkinson's diseaseQ37356891
Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cellsQ37610451
Redox homeostasis and cellular stress response in aging and neurodegenerationQ37655706
Levetiracetam in brain ischemia: clinical implications in neuroprotection and prevention of post-stroke epilepsyQ37772663
Perspectives on molecular targeted therapies and clinical trials for neurodegenerative diseasesQ37983057
Establishment of experimental models for Alzheimer's disease researchQ38106507
Post-treatment with voltage-gated Na(+) channel blocker attenuates kainic acid-induced apoptosis in rat primary hippocampal neuronsQ38275406
Animal models of Parkinson's disease: An updated overview.Q38581837
What is hormesis and its relevance to healthy aging and longevity?Q38582970
Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivoQ38952930
Protective effects of zonisamide against rotenone-induced neurotoxicityQ39076196
Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathwaysQ39571186
Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial.Q39858360
Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse modelsQ39924456
Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes.Q40232814
Zonisamide inhibits nitric oxide synthase activity induced by N-methyl-D-aspartate and buthionine sulfoximine in the rat hippocampus.Q41740998
Electrophysiological actions of felbamate on rat striatal neurones.Q42177610
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibitionQ42439876
The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1β and TNF-α expression in rat hippocampusQ42460187
Electrophysiological actions of zonisamide on striatal neurons: Selective neuroprotection against complex I mitochondrial dysfunction.Q42463079
Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells.Q42480993
Zonisamide as a neuroprotective agent in an adult gerbil model of global forebrain ischemia: a histological, in vivo microdialysis and behavioral studyQ42546501
Phenobarbital augments hypothermic neuroprotection.Q42725654
Zonisamide attenuates MPTP neurotoxicity in marmosetsQ42858552
Redox proteomics in aging rat brain: involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging processQ42862763
Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.Q42988173
Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in miceQ43083221
Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease.Q43288037
Protective effect of carbamazepine on kainic acid-induced neuronal cell death through activation of signal transducer and activator of transcription-3.Q43439841
Neuroprotective effects of lamotrigine and remacemide on excitotoxicity induced by glutamate agonists in isolated chick retinaQ43649930
Neuroprotective effects of the mood stabilizer lamotrigine against glutamate excitotoxicity: roles of chromatin remodelling and Bcl-2 inductionQ43779242
Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI).Q44154771
Neuroprotection of axons with phenytoin in experimental allergic encephalomyelitisQ44190587
Polytherapy in epilepsy: the experimental evidenceQ44225576
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivationQ44280661
Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic miceQ44301949
Ionotropic glutamate receptors: still a target for neuroprotection in brain ischemia? Insights from in vitro studiesQ44332173
Lamotrigine and remacemide protect striatal neurons against in vitro ischemia: an electrophysiological study.Q44535353
Neuroprotective properties of topiramate in the lithium-pilocarpine model of epilepsyQ44639225
Levetiracetam protects against kainic acid-induced toxicityQ44707450
P433issue1-2
P921main subjectneurodegenerationQ1755122
P304page(s)340-352
P577publication date2015-12-31
P1433published inNeurochemical ResearchQ15716728
P1476titleNeuroprotection as a Potential Therapeutic Perspective in Neurodegenerative Diseases: Focus on Antiepileptic Drugs
P478volume41