Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin.

scientific article published on 2 December 2013

Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/CNS.12186
P932PMC publication ID6493036
P698PubMed publication ID24289518

P2093author name stringTing Li
Zheng Wang
Jia Li
Weidong Le
Yu Tang
Xiao-Jie Zhang
P2860cites workValproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse modelsQ39924456
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Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generationQ40170530
Effect of ischemic neuronal insults on amyloid precursor protein processingQ40263442
Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanismsQ40371754
Neprilysin regulates amyloid Beta peptide levelsQ40595769
Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's diseaseQ43121979
Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidineQ44220740
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer.Q44260410
Presenilin 1 gene silencing by S‐adenosylmethionine: a treatment for Alzheimer disease?Q44411058
Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's diseaseQ44446243
Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer's disease neuropathology in APPSwe/PS1A246E transgenic miceQ47385458
Valproic acid attenuates neuronal loss in the brain of APP/PS1 double transgenic Alzheimer's disease mice modelQ48350023
Decreased expression and activity of neprilysin in Alzheimer disease are associated with cerebral amyloid angiopathyQ48404228
A comparative study of modified Bielschowsky, Bodian and thioflavin S stains on Alzheimer's neurofibrillary tanglesQ48424499
The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylationQ48486318
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteinsQ48601563
Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia.Q53378635
Analysis of the human CD10/neutral endopeptidase 24.11 promoter region: two separate regulatory elementsQ72252440
Tissue-specific expression of rat neutral endopeptidase (neprilysin) mRNAsQ72631526
[Impact of treatment with acetylcholinesterase inhibitors, valproic acid and antipsychotics on aggressive behaviour in Alzheimer's type dementia]Q95431091
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian developmentQ22010765
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complexQ24324026
Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorderQ24652360
The amyloid precursor protein: beyond amyloidQ24680465
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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid proteinQ29547803
The blood-brain barrier: an overview: structure, regulation, and clinical implicationsQ29616839
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The new generation of GABA enhancers. Potential in the treatment of epilepsyQ34320951
Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?Q34687570
Hypoxia signaling to genes: significance in Alzheimer's diseaseQ34995070
Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expressionQ35214758
Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease.Q36512147
Update on hypertension and Alzheimer's diseaseQ36582774
Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascadeQ36735157
Neuropsychiatric and behavioral aspects of trisomy 21.Q36772007
How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARn" model (latent early-life associated regulation) may explain the triggering of AD.Q36789936
Histone deacetylases: focus on the nervous systemQ36832256
DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe.Q36873208
Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolismQ37017923
Amyloid-degrading enzymes as therapeutic targets in Alzheimer's diseaseQ37130677
Neprilysin and amyloid beta peptide degradationQ37130680
Pathological role of hypoxia in Alzheimer's diseaseQ37579332
The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growthQ38299684
Relation of cerebral infarctions to dementia and cognitive function in older personsQ38428811
Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathwaysQ39571186
Valproic acid enhances microglial phagocytosis of amyloid-beta(1-42).Q39710191
P433issue3
P304page(s)209-217
P577publication date2013-12-02
P1433published inCNS Neuroscience & TherapeuticsQ5013184
P1476titleValproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin.
P478volume20

Reverse relations

cites work (P2860)
Q48225902(-)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer's disease model mice by upregulating neprilysin expression.
Q600456145-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer's disease
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Q47732984Long-lasting recognition memory impairment and alterations in brain levels of cytokines and BDNF induced by maternal deprivation: effects of valproic acid and topiramate
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Q96018023Targeting Neprilysin (NEP) pathways: A potential new hope to defeat COVID-19 ghost
Q50707979Valproic Acid Modifies Synaptic Structure and Accelerates Neurite Outgrowth Via the Glycogen Synthase Kinase-3β Signaling Pathway in an Alzheimer's Disease Model.
Q64117819Valproic Acid Stimulates Hippocampal Neurogenesis Activating the Wnt/β-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer's Disease
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