Novel isotopic N,N-dimethyl leucine (iDiLeu) reagents enable absolute quantification of peptides and proteins using a standard curve approach

scientific article

Novel isotopic N,N-dimethyl leucine (iDiLeu) reagents enable absolute quantification of peptides and proteins using a standard curve approach is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1021239628
P356DOI10.1007/S13361-014-1012-Y
P932PMC publication ID4276538
P698PubMed publication ID25377360
P5875ResearchGate publication ID267931899

P2093author name stringLingjun Li
Feng Xiang
Christopher B Lietz
Tyler Greer
P2860cites workQuantification of High-Molecular Weight Protein Platforms by AQUA Mass Spectrometry as Exemplified for the CD95 Death-Inducing Signaling Complex (DISC).Q38588695
Quantitative analysis of the human AKR family members in cancer cell lines using the mTRAQ/MRM approachQ39173100
Peptide labeling with isobaric tags yields higher identification rates using iTRAQ 4-plex compared to TMT 6-plex and iTRAQ 8-plex on LTQ OrbitrapQ41863038
Enhancement of ionization efficiency by electrochemical reaction products in on-line electrochemistry/electrospray ionization Fourier transform ion cyclotron resonance mass spectrometryQ43941078
The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modificationsQ45275572
Enhanced sample multiplexing for nitrotyrosine-modified proteins using combined precursor isotopic labeling and isobaric tagging.Q46036268
Absolute quantification of potential cancer markers in clinical tissue homogenates using multiple reaction monitoring on a hybrid triple quadrupole/linear ion trap tandem mass spectrometerQ46073781
Multiple reaction monitoring of mTRAQ-labeled peptides enables absolute quantification of endogenous levels of a potential cancer marker in cancerous and normal endometrial tissuesQ46481136
Hyperplex-MRM: a hybrid multiple reaction monitoring method using mTRAQ/iTRAQ labeling for multiplex absolute quantification of human colorectal cancer biomarkerQ47874059
The parallel reaction monitoring method contributes to a highly sensitive polyubiquitin chain quantification.Q50946090
Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome.Q53579885
Isotope dilution--mass spectrometric quantification of specific proteins: model application with apolipoprotein A-IQ64134355
Chromatographic behaviour of peptides following dimethylation with H2/D2-formaldehyde: implications for comparative proteomicsQ85348445
Five-plex isotope dimethyl labeling for quantitative proteomicsQ87042272
Multiplexed parallel reaction monitoring targeting histone modifications on the QExactive mass spectrometerQ87867249
Controlling deuterium isotope effects in comparative proteomicsQ95805969
i-Tracker: for quantitative proteomics using iTRAQ.Q21266606
Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MSQ24680943
Comparative study of three proteomic quantitative methods, DIGE, cICAT, and iTRAQ, using 2D gel- or LC-MALDI TOF/TOF.Q33235253
N,N-dimethyl leucines as novel isobaric tandem mass tags for quantitative proteomics and peptidomicsQ33539354
Analysis of the benzene oxide-DNA adduct 7-phenylguanine by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring: application to DNA from exposed mice and humansQ33616197
mTRAQ-based quantification of potential endometrial carcinoma biomarkers from archived formalin-fixed paraffin-embedded tissuesQ33641661
Identification of longitudinally dynamic biomarkers in Alzheimer's disease cerebrospinal fluid by targeted proteomicsQ33769278
High-throughput peptide quantification using mTRAQ reagent triplexQ33827039
Quantitative gingival crevicular fluid proteome in health and periodontal disease using stable isotope chemistries and mass spectrometryQ34025805
Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomicsQ34292436
MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes.Q34434094
Large-scale collision cross-section profiling on a traveling wave ion mobility mass spectrometer.Q34474082
COMPASS: a suite of pre- and post-search proteomics software tools for OMSSAQ34629832
Differential proteomic analysis of abnormal intramyoplasmic aggregates in desminopathyQ34703663
Gas-phase purification enables accurate, multiplexed proteome quantification with isobaric taggingQ35488768
MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomicsQ35491186
A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease.Q36006127
iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomicsQ36209046
Targeted proteomic quantification on quadrupole-orbitrap mass spectrometer.Q36455720
Protein biomarker discovery and validation: the long and uncertain path to clinical utilityQ36561644
Absolute quantification of prion protein (90-231) using stable isotope-labeled chymotryptic peptide standards in a LC-MRM AQUA workflowQ36630654
Applications of selected reaction monitoring (SRM)-mass spectrometry (MS) for quantitative measurement of signaling pathwaysQ37149443
Proteomic analysis revealed the altered tear protein profile in a rabbit model of Sjögren's syndrome-associated dry eye.Q37238671
Multiple reaction monitoring-based, multiplexed, absolute quantitation of 45 proteins in human plasmaQ37294438
Perspectives of targeted mass spectrometry for protein biomarker verificationQ37481709
The bottleneck in the cancer biomarker pipeline and protein quantification through mass spectrometry-based approaches: current strategies for candidate verificationQ37653063
Improved isobaric tandem mass tag quantification by ion mobility mass spectrometryQ37724834
Quantitative proteome analysis of age-related changes in mouse gastrocnemius muscle using mTRAQ.Q38483307
P433issue1
P304page(s)107-119
P577publication date2014-11-07
P1433published inJournal of the American Society for Mass SpectrometryQ3020250
P1476titleNovel isotopic N,N-dimethyl leucine (iDiLeu) reagents enable absolute quantification of peptides and proteins using a standard curve approach
P478volume26

Reverse relations

cites work (P2860)
Q60919481A Strategy for Discovery and Verification of Candidate Biomarkers in Cerebrospinal Fluid of Preclinical Alzheimer's Disease
Q36956324Biomarker discovery in mass spectrometry-based urinary proteomics
Q28547212Custom 4-Plex DiLeu Isobaric Labels Enable Relative Quantification of Urinary Proteins in Men with Lower Urinary Tract Symptoms (LUTS)
Q64074945Data Independent Acquisition Mass Spectrometry Method for Improved Neuropeptidomic Coverage in Crustacean Neural Tissue Extracts
Q39560760Evaluation and Application of Dimethylated Amino Acids as Isobaric Tags for Quantitative Proteomics of the TGF-β/Smad3 Signaling Pathway.
Q61813107HOTMAQ: A Multiplexed Absolute Quantification Method for Targeted Proteomics
Q43134357High-resolution enabled 12-plex DiLeu isobaric tags for quantitative proteomics
Q36342472Improving data quality and preserving HCD-generated reporter ions with EThcD for isobaric tag-based quantitative proteomics and proteome-wide PTM studies
Q48260815Mass Defect-Based Dimethyl Pyrimidinyl Ornithine (DiPyrO) Tags for Multiplex Quantitative Proteomics.
Q47829993Mass Spectrometry Imaging: A Review of Emerging Advancements and Future Insights.
Q47353598New ionization tags based on the structure of the 5-azoniaspiro[4.4]nonyl tag for a sensitive peptide sequencing by mass spectrometry.
Q47847400Relative quantitation of neuropeptides at multiple developmental stages of the American lobster using N, N-dimethyl leucine isobaric tandem mass tags.
Q90330418Sample Multiplexing Strategies in Quantitative Proteomics
Q89733084Temporal Study of the Perturbation of Crustacean Neuropeptides Due to Severe Hypoxia Using 4-Plex Reductive Dimethylation

Search more.