iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics

scientific article

iTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/MCP.M111.014423
P932PMC publication ID3433912
P698PubMed publication ID22210691

P2093author name stringSteven A Carr
Jacob D Jaffe
Karl R Clauser
Philipp Mertins
D R Mani
Namrata D Udeshi
Jinal Patel
Shao-en Ong
P2860cites workGlobal, in vivo, and site-specific phosphorylation dynamics in signaling networksQ27864128
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomicsQ28131742
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantificationQ29547200
Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagentsQ29547450
Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTipsQ29614831
Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assaysQ33532846
More than 100,000 detectable peptide species elute in single shotgun proteomics runs but the majority is inaccessible to data-dependent LC-MS/MS.Q33817365
Tandem Mass Tags: A Novel Quantification Strategy for Comparative Analysis of Complex Protein Mixtures by MS/MSQ34192662
iTRAQ underestimation in simple and complex mixtures: "the good, the bad and the ugly".Q35002931
Gas-phase purification enables accurate, multiplexed proteome quantification with isobaric taggingQ35488768
MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomicsQ35491186
Robust and sensitive iTRAQ quantification on an LTQ Orbitrap mass spectrometerQ36914493
Improved precision of iTRAQ and TMT quantification by an axial extraction field in an Orbitrap HCD cellQ40796871
The SCX/IMAC enrichment approach for global phosphorylation analysis by mass spectrometryQ42122474
Addressing accuracy and precision issues in iTRAQ quantitationQ42427843
Multiple reaction monitoring of mTRAQ-labeled peptides enables absolute quantification of endogenous levels of a potential cancer marker in cancerous and normal endometrial tissuesQ46481136
Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics.Q51758332
Optimized Orbitrap HCD for quantitative analysis of phosphopeptides.Q51835380
High Precision Quantitative Proteomics Using iTRAQ on an LTQ Orbitrap: A New Mass Spectrometric Method Combining the Benefits of AllQ57184382
High amplitude short time excitation: a method to form and detect low mass product ions in a quadrupole ion trap mass spectrometerQ81623139
Minimising iTRAQ ratio compression through understanding LC-MS elution dependence and high-resolution HILIC fractionationQ84052397
Evaluation of different multidimensional LC-MS/MS pipelines for isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of potato tubers in response to cold storageQ84767773
P433issue6
P304page(s)M111.014423
P577publication date2011-12-30
P1433published inMolecular & Cellular ProteomicsQ6895932
P1476titleiTRAQ labeling is superior to mTRAQ for quantitative global proteomics and phosphoproteomics
P478volume11

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cites work (P2860)
Q92123505A BONCAT-iTRAQ method enables temporally resolved quantitative profiling of newly synthesised proteins in Leishmania mexicana parasites during starvation
Q38731736A Biologist's Field Guide to Multiplexed Quantitative Proteomics
Q35722825A Proteomic Analysis of Individual and Gender Variations in Normal Human Urine and Cerebrospinal Fluid Using iTRAQ Quantification
Q35928781A Proteomic Approach Identifies Candidate Early Biomarkers to Predict Severe Dengue in Children
Q64102059A Review on Quantitative Multiplexed Proteomics
Q37167318Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster.
Q38934587Advances in mass spectrometry based strategies to study receptor tyrosine kinases.
Q37289441Amine-reactive neutron-encoded labels for highly plexed proteomic quantitation
Q40281817An atlas of human kinase regulation
Q55402062Benchmarking common quantification strategies for large-scale phosphoproteomics.
Q31162178Benchmarking substrate-based kinase activity inference using phosphoproteomic data
Q93222478Carcinogenic Helicobacter pylori Strains Selectively Dysregulate the In Vivo Gastric Proteome, Which May Be Associated with Stomach Cancer Progression
Q28535124Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation
Q36293528Cellular proteomic analysis of porcine circovirus type 2 and classical swine fever virus coinfection in porcine kidney-15 cells using isobaric tags for relative and absolute quantitation-coupled LC-MS/MS.
Q42361173Comparative Proteomic Analysis of Paulownia fortunei Response to Phytoplasma Infection with Dimethyl Sulfate Treatment.
Q34141777Comparing SILAC- and stable isotope dimethyl-labeling approaches for quantitative proteomics
Q37238264Connecting genomic alterations to cancer biology with proteomics: the NCI Clinical Proteomic Tumor Analysis Consortium
Q54752470Cost-effective isobaric tagging for quantitative phosphoproteomics using DiART reagents.
Q28547212Custom 4-Plex DiLeu Isobaric Labels Enable Relative Quantification of Urinary Proteins in Men with Lower Urinary Tract Symptoms (LUTS)
Q36816520Development and characterization of novel 8-plex DiLeu isobaric labels for quantitative proteomics and peptidomics
Q30939895EBprot: Statistical analysis of labeling-based quantitative proteomics data.
Q30234679Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease
Q39560760Evaluation and Application of Dimethylated Amino Acids as Isobaric Tags for Quantitative Proteomics of the TGF-β/Smad3 Signaling Pathway.
Q63859501Evaluation of a Dual Isolation Width Acquisition Method for Isobaric Labeling Ratio Decompression
Q39012307Evaluation of the accuracy of protein quantification using isotope TMPP-labeled peptides
Q37164270Genome-scale proteome quantification by DEEP SEQ mass spectrometry
Q38938771Global 3' UTR shortening has a limited effect on protein abundance in proliferating T cells
Q28659266Global analysis of the effects of the V2 receptor antagonist satavaptan on protein phosphorylation in collecting duct
Q37255788Global cellular response to chemotherapy-induced apoptosis
Q37400812Green fluorescent protein expression triggers proteome changes in breast cancer cells.
Q43134357High-resolution enabled 12-plex DiLeu isobaric tags for quantitative proteomics
Q37023610Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses
Q37618636Integrated proteomic analysis of post-translational modifications by serial enrichment.
Q91686467Integrative Proteo-genomic Analysis to Construct CNA-protein Regulatory Map in Breast and Ovarian Tumors
Q51073279Integrative quantitation enables a comprehensive proteome comparison of two Mycoplasma pneumoniae genetic perturbations.
Q33850627Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels
Q34669427Isobaric labeling-based relative quantification in shotgun proteomics
Q36948646Isobaric protein-level labeling strategy for serum glycoprotein quantification analysis by liquid chromatography-tandem mass spectrometry
Q58748104Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast
Q38217990Mass spectrometry-driven phosphoproteomics: patterning the systems biology mosaic
Q42374193Mechanistic Evaluation and Translational Signature of Gemcitabine-induced Chemoresistance by Quantitative Phosphoproteomics Analysis with iTRAQ Labeling Mass Spectrometry
Q34434094MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes.
Q36040379Multiplexed, Quantitative Workflow for Sensitive Biomarker Discovery in Plasma Yields Novel Candidates for Early Myocardial Injury.
Q34315255Next-generation proteomics: towards an integrative view of proteome dynamics.
Q45110739Novel and cost-effective 6-plex isobaric tagging reagent, DiART, is effective for identification and relative quantification of complex protein mixtures using PQD fragmentation
Q34772405Novel isotopic N,N-dimethyl leucine (iDiLeu) reagents enable absolute quantification of peptides and proteins using a standard curve approach
Q24300072Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites
Q51118716Phosphoproteomics analysis identifies novel candidate substrates of the non-receptor tyrosine kinase, SRMS
Q30354536Phosphoproteomics in the Age of Rapid and Deep Proteome Profiling.
Q35623711Plasma membrane proteomic analysis of human Gastric Cancer tissues: revealing flotillin 1 as a marker for Gastric Cancer
Q37677954Protected amine labels: a versatile molecular scaffold for multiplexed nominal mass and sub-Da isotopologue quantitative proteomic reagents.
Q90269148Proteomic Analysis of the Early Development of the Phalaenopsis amabilis Flower Bud under Low Temperature Induction Using the iTRAQ/MRM Approach
Q36318689Proteomic analysis demonstrates activator- and chromatin-specific recruitment to promoters.
Q26784593Proteomic approaches to identify circulating biomarkers in patients with abdominal aortic aneurysm
Q36120273Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase
Q34076676Proteomics analysis reveals protein expression differences for hypopharyngeal gland activity in the honeybee, Apis mellifera carnica Pollmann.
Q27016578Proteomics approaches for the studies of bone metabolism
Q57721609Quantitative Proteomic Approaches in Mouse: Stable Isotope Incorporation by Metabolic (SILAC) or Chemical Labeling (Reductive Dimethylation) Combined with High-Resolution Mass Spectrometry
Q91811791Quantitative proteomic analysis reveals the ethanologenic metabolism regulation of Ethanoligenens harbinense by exogenous ethanol addition
Q48021398Quantitative, multiplexed workflow for deep analysis of human blood plasma and biomarker discovery by mass spectrometry.
Q28538153Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming
Q47672478Recent advances in phosphoproteomics and application to neurological diseases
Q26781752Recent findings and technological advances in phosphoproteomics for cells and tissues
Q38380859Relative protein quantification and accessible biology in lung tumor proteomes from four LC-MS/MS discovery platforms.
Q36617725Relative quantification of biomarkers using mixed-isotope labeling coupled with MS.
Q91940335Reproducibility of biomarker identifications from mass spectrometry proteomic data in cancer studies
Q89486219Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry
Q86745443Sensing Small Changes in Protein Abundance: Stimulation of Caco-2 Cells by Human Whey Proteins
Q26829144Status of large-scale analysis of post-translational modifications by mass spectrometry
Q34626974Target identification and mechanism of action in chemical biology and drug discovery
Q34630866Targeted quantitation of proteins by mass spectrometry.
Q36771005The clinical impact of recent advances in LC-MS for cancer biomarker discovery and verification
Q24611461Unambiguous phosphosite localization using electron-transfer/higher-energy collision dissociation (EThcD)
Q51075208iTRAQ quantitative proteomic analysis reveals the pathways for methanation of propionate facilitated by magnetite.
Q36716644iTRAQ-Based and Label-Free Proteomics Approaches for Studies of Human Adenovirus Infections

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