C terminus of Clostridium perfringens enterotoxin downregulates CLDN4 and sensitizes ovarian cancer cells to Taxol and Carboplatin

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C terminus of Clostridium perfringens enterotoxin downregulates CLDN4 and sensitizes ovarian cancer cells to Taxol and Carboplatin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-10-1644
P932PMC publication ID3075966
P698PubMed publication ID21123456
P5875ResearchGate publication ID49650667

P2093author name stringSamuel C Mok
Bruce McClane
Qing Zeng
Zhijian Gao
Ross S Berkowitz
William R Welch
Babak Litkouhi
Elizabeth I O Garner
Xiaoyin Xu
P2860cites workClaudin multigene family encoding four-transmembrane domain protein components of tight junction strandsQ22008687
The role of the ubiquitination-proteasome pathway in breast cancer: applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancerQ24794927
Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epitheliumQ28203495
Multifunctional strands in tight junctionsQ28210051
Cancer statistics, 2009Q29547625
Three-dimensional culture models of normal and malignant breast epithelial cellsQ30496418
Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancerQ31833417
Evaluation of carboplatin pharmacokinetics in the absence and presence of paclitaxelQ33504313
Molecular structure of tight junctions and their role in epithelial transport.Q34302113
Clostridium perfringens enterotoxin elicits rapid and specific cytolysis of breast carcinoma cells mediated through tight junction proteins claudin 3 and 4.Q35098046
Differential gene expression in ovarian carcinoma: identification of potential biomarkersQ35103006
Intraperitoneal antineoplastic drug delivery: rationale and resultsQ35121705
Deletion analysis of the Clostridium perfringens enterotoxinQ35544215
Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxinQ35756974
Claudin proteins in human cancer: promising new targets for diagnosis and therapyQ36305148
Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cellsQ36534977
Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cellsQ37200457
Localization of the receptor-binding region of Clostridium perfringens enterotoxin utilizing cloned toxin fragments and synthetic peptides. The 30 C-terminal amino acids define a functional binding regionQ38334803
Recombinant CPE fused to tumor necrosis factor targets human ovarian cancer cells expressing the claudin-3 and claudin-4 receptorsQ39830843
Production and characterization of monoclonal antibodies to Clostridium perfringens enterotoxin.Q40171469
An evaluation of cytotoxicity of the taxane and platinum agents combination treatment in a panel of human ovarian carcinoma cell linesQ40407981
Treatment of chemotherapy-resistant human ovarian cancer xenografts in C.B-17/SCID mice by intraperitoneal administration of Clostridium perfringens enterotoxinQ40421113
Comparative biochemical and immunocytochemical studies reveal differences in the effects of Clostridium perfringens enterotoxin on polarized CaCo-2 cells versus Vero cellsQ40793623
Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier.Q40925316
Evidence for Clostridium perfringens enterotoxin (CPE) inducing a mitogenic and cytokine response in vitro and a cytokine response in vivoQ40985115
Epithelial cells retain junctions during mitosisQ41577301
Up-regulation by IGF-I of proliferating cell nuclear antigen and Bcl-2 protein expression in human uterine leiomyoma cellsQ43794640
p53 Tumor suppressor protein content in human uterine leiomyomas and its down-regulation by 17 beta-estradiolQ44089118
A novel strategy for the enhancement of drug absorption using a claudin modulatorQ45188971
Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic targetQ51019711
Role of C-terminal regions of the C-terminal fragment of Clostridium perfringens enterotoxin in its interaction with claudin-4.Q52565720
Intraperitoneal cisplatin and paclitaxel in ovarian cancer.Q53263238
Differences in expression patterns of the tight junction proteins,claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours.Q53264168
Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary.Q53609842
Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas.Q53924073
Occludin and claudin-1 concentrate in the midbody of immortalized mouse hepatocytes during cell divisionQ73446907
Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecinQ73717910
Clostridium perfringens enterotoxin as a novel-targeted therapeutic for brain metastasisQ81097997
New insights into the cytotoxic mechanisms of Clostridium perfringens enterotoxinQ83345892
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectovarian cancerQ172341
Clostridium perfringensQ309465
carboplatinQ415588
paclitaxelQ423762
P304page(s)1065-1074
P577publication date2010-12-01
P1433published inClinical Cancer ResearchQ332253
P1476titleC terminus of Clostridium perfringens enterotoxin downregulates CLDN4 and sensitizes ovarian cancer cells to Taxol and Carboplatin
P478volume17

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cites work (P2860)
Q38761851Claudin-4 binder C-CPE 194 enhances effects of anticancer agents on pancreatic cancer cell lines via a MAPK pathway
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Q35532292Claudins 10 and 18 are predominantly expressed in lung adenocarcinomas and in tumors of nonsmokers
Q37880969Claudins in lung diseases
Q26851347Claudins overexpression in ovarian cancer: potential targets for Clostridium Perfringens Enterotoxin (CPE) based diagnosis and therapy
Q26752971Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications
Q35564030Clostridium perfringens enterotoxin (CPE) and CPE-binding domain (c-CPE) for the detection and treatment of gynecologic cancers
Q92441177Development of Human Monoclonal Antibody for Claudin-3 Overexpressing Carcinoma Targeting
Q35971814Epithelial-mesenchymal transition in ovarian carcinoma
Q57296168Functionalization of gold-nanoparticles by the Clostridium perfringens enterotoxin C-terminus for tumor cell ablation using the gold nanoparticle-mediated laser perforation technique
Q37377308Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines
Q36773924Overexpression of claudin-4 may be involved in endometrial tumorigenesis
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Q38026601Targeting claudin-4 in human pancreatic cancer
Q38242808Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.
Q38811256The interaction of Clostridium perfringens enterotoxin with receptor claudins
Q38927656The role of claudins in cancer metastasis
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Q38199103Trends in drug delivery through tissue barriers containing tight junctions.
Q35215182Use of Clostridium perfringens Enterotoxin and the Enterotoxin Receptor-Binding Domain (C-CPE) for Cancer Treatment: Opportunities and Challenges

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