Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death

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Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1172/JCI0213265
P932PMC publication ID150906
P698PubMed publication ID11901182

P50authorImran N. MungrueQ55909082
P2093author name stringRobert Gros
Duncan J Stewart
Jagdish Butany
Richard Schulz
Mansoor Husain
Tamas Csont
Xiaomang You
Azar Azad
Asif Pirani
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Verapamil ameliorates the clinical and pathological course of murine myocarditisQ35609065
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthaseQ35986312
Complete heart block and sudden death in mice overexpressing calreticulinQ36166973
Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophagesQ36244224
Superoxide generation by endothelial nitric oxide synthase: the influence of cofactorsQ36253833
Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic miceQ36311525
Myocardial capillary permeability for small hydrophilic indicators during normal physiological conditions and after ischemia and reperfusionQ36949763
Role of nitric oxide in obesity-induced beta cell diseaseQ37369915
Inducible nitric oxide synthase: what difference does it make?Q37374566
Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoproteinQ37587741
Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthaseQ38311029
Nitric oxide in cardiovascular diseasesQ40405159
NOS2 mediates opposing effects in models of acute and chronic cardiac rejection: insights from NOS2-knockout miceQ42136278
Induction and potential biological relevance of a Ca(2+)-independent nitric oxide synthase in the myocardiumQ42712096
Cardiac-specific overexpression of inducible nitric oxide synthase does not result in severe cardiac dysfunctionQ43851357
Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricleQ45096844
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Conduction disturbances and increased atrial vulnerability in Connexin40-deficient mice analyzed by transesophageal stimulation.Q51469223
Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.Q52507356
Histochemical methods for separate, consecutive and simultaneous demonstration of acetylcholinesterase and norepinephrine in cryostat sections.Q54516964
Exacerbation of reperfusion arrhythmias by sudden oxidant stressQ68865890
Targeting of transgene expression to the vascular endothelium of mice by homologous recombination at the thrombomodulin locusQ70934675
Expression of inducible nitric oxide synthase in human heart failureQ71129305
Conditional transgene expression in the heartQ71590968
Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitroQ71656579
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthaseQ71694221
S-methylisothiourea inhibits inducible nitric oxide synthase and improves left ventricular performance after acute myocardial infarctionQ71700654
Nitric oxide synthase activities in human myocardiumQ72067146
Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of Duchenne muscular dystrophyQ73092279
Effects of nitric oxide synthase inhibition on Basal function and the force-frequency relationship in the normal and failing human heart in vivoQ77130008
Nitric oxide and inflammatory bowel diseasesQ77586534
Attenuated acute cardiac rejection in NOS2 -/- recipients correlates with reduced apoptosisQ78171893
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectoverexpressionQ61643320
P304page(s)735-743
P577publication date2002-03-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleCardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death
P478volume109

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