scholarly article | Q13442814 |
P819 | ADS bibcode | 2003PNAS..10015818S |
P356 | DOI | 10.1073/PNAS.2636938100 |
P932 | PMC publication ID | 307651 |
P698 | PubMed publication ID | 14673093 |
P5875 | ResearchGate publication ID | 8961761 |
P50 | author | Laurie Glimcher | Q6501587 |
Matthias von Herrath | Q64532773 | ||
P2093 | author name string | Brandon M Sullivan | |
Susanne J Szabo | |||
Amy Juedes | |||
P2860 | cites work | T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells | Q74082060 |
Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection | Q74813303 | ||
c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function | Q77378951 | ||
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet | Q77476285 | ||
A novel transcription factor, T-bet, directs Th1 lineage commitment | Q22253874 | ||
Interleukin-10 and the interleukin-10 receptor | Q24290912 | ||
T cell receptor antagonist peptides induce positive selection | Q29618820 | ||
Response to influenza infection in mice with a targeted disruption in the interferon gamma gene | Q30442876 | ||
In vivo cross-presentation of a soluble protein antigen: kinetics, distribution, and generation of effector CTL recognizing dominant and subdominant epitopes | Q31583375 | ||
Antigen presentation by MHC class I and its regulation by interferon gamma | Q33536525 | ||
Transcriptional regulation of T lymphocyte development and function | Q33652463 | ||
Protective role of gamma interferon during the recall response to influenza virus. | Q33783554 | ||
T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells | Q33952975 | ||
Mechanisms of interleukin-10-mediated immune suppression | Q34285968 | ||
MAP kinases in the immune response | Q34542231 | ||
Influence of effector molecules on the CD8(+) T cell response to infection | Q34612543 | ||
Biology and pathogenesis of lymphocytic choriomeningitis virus infection. | Q34622909 | ||
Effector and memory T-cell differentiation: implications for vaccine development | Q34632071 | ||
CD8 T cell responses to infectious pathogens. | Q34987912 | ||
Autoimmune diabetes can be induced in transgenic major histocompatibility complex class II-deficient mice | Q36362059 | ||
Lineage-specific requirement for signal transducer and activator of transcription (Stat)4 in interferon gamma production from CD4(+) versus CD8(+) T cells | Q36368055 | ||
The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease | Q36370178 | ||
Molecularly engineered vaccine which expresses an immunodominant T-cell epitope induces cytotoxic T lymphocytes that confer protection from lethal virus infection. | Q36831093 | ||
Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo | Q36918873 | ||
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells | Q37139786 | ||
DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. | Q39869845 | ||
Memory CD8(+) T cells undergo peripheral tolerance | Q40714192 | ||
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells | Q40757721 | ||
The molecular cell biology of interferon-gamma and its receptor | Q40898233 | ||
Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. | Q41365854 | ||
Switch of CD8 T cells to noncytolytic CD8-CD4- cells that make TH2 cytokines and help B cells. | Q41547198 | ||
Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response | Q43986613 | ||
Lineage-specific differences among CD8+ T cells in their dependence of NF-kappa B/Rel signaling | Q44154232 | ||
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice | Q45854348 | ||
Molecular and functional profiling of memory CD8 T cell differentiation. | Q52008481 | ||
Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. | Q52111650 | ||
Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells | Q71968307 | ||
NF-kappa B is required for the positive selection of CD8+ thymocytes | Q73112917 | ||
Differential requirement of CD28 for IL-12 receptor expression and function in CD4(+) and CD8(+) T cells | Q73443937 | ||
Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation | Q73808233 | ||
P433 | issue | 26 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | cell function | Q95674809 |
P1104 | number of pages | 6 | |
P304 | page(s) | 15818-15823 | |
P577 | publication date | 2003-12-12 | |
P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
P1476 | title | Antigen-driven effector CD8 T cell function regulated by T-bet | |
P478 | volume | 100 |
Q36140303 | A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria |
Q39835072 | A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity |
Q39601970 | A common promoter variant of TBX21 is associated with allele specific binding to Yin-Yang 1 and reduced gene expression |
Q37723628 | A genome-wide regulatory network identifies key transcription factors for memory CD8⁺ T-cell development. |
Q37747078 | A pivotal role for interleukin-27 in CD8+ T cell functions and generation of cytotoxic T lymphocytes |
Q33981265 | A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection |
Q90631508 | Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8+ T cell immunity and prolongs murine cardiac allograft survival |
Q58610784 | An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion |
Q41889400 | Antigen-specific naive CD8+ T cells produce a single pulse of IFN-γ in vivo within hours of infection, but without antiviral effect |
Q92376089 | Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade |
Q36084006 | Autocrine IFN-γ promotes naive CD8 T cell differentiation and synergizes with IFN-α to stimulate strong function |
Q37028954 | Blimp-1 connects the intrinsic and extrinsic regulation of T cell homeostasis. |
Q38980123 | CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut. |
Q34311528 | CD4⁺ and CD8⁺ T cell-dependent antiviral immunity requires STIM1 and STIM2. |
Q82388008 | CD8(+) T cells in facioscapulohumeral muscular dystrophy patients with inflammatory features at muscle MRI |
Q30432007 | CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesis |
Q45376613 | CNS repair requires both effector and regulatory T cells with distinct temporal and spatial profiles |
Q37333899 | CXCR3 deficiency increases susceptibility to genital herpes simplex virus type 2 infection: Uncoupling of CD8+ T-cell effector function but not migration |
Q64968682 | Checkpoint Blockade Rescues the Repressive Effect of Histone Deacetylases Inhibitors on γδ T Cell Function. |
Q35071484 | Checkpoint blockade immunotherapy relies on T-bet but not Eomes to induce effector function in tumor-infiltrating CD8+ T cells |
Q33944309 | Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 |
Q95327696 | Clonal expansion of innate and adaptive lymphocytes |
Q36236434 | Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques |
Q34539858 | Common gamma chain (γc) cytokines differentially potentiate TNFR family signaling in antigen-activated CD8(+) T cells |
Q36665239 | CpG and interleukin-15 synergize to enhance IFN-γ production by activated CD8+ T cells |
Q34286922 | Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. |
Q53180942 | Cyclosporine A Inhibits the T-bet-Dependent Antitumor Response of CD8(+) T Cells. |
Q48191742 | Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1. |
Q38069828 | Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection |
Q38433251 | Delayed differentiation of potent effector CD8+ T cells reducing viremia and reservoir seeding in acute HIV infection. |
Q52901833 | Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease. |
Q35913945 | Differential Impact of In Vivo CD8+ T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques. |
Q33596651 | Differential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes |
Q91691829 | Discovery of Small Molecules for the Reversal of T Cell Exhaustion |
Q36718025 | Disparate roles for STAT5 in primary and secondary CTL responses. |
Q34187239 | Dissociating markers of senescence and protective ability in memory T cells |
Q34073854 | Distal regions of the human IFNG locus direct cell type-specific expression |
Q35088009 | Distinct compartmentalization of CD4+ T-cell effector function versus proliferative capacity during pulmonary cryptococcosis |
Q37117559 | Distinct regulation of effector and memory T-cell differentiation. |
Q35740229 | Diverse functions of distal regulatory elements at the IFNG locus |
Q41565237 | Diverse roles for T-bet in the effector responses required for resistance to infection. |
Q37508408 | Diversity in CD8(+) T cell differentiation. |
Q34230513 | Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction |
Q64071978 | ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression |
Q36362657 | Early control of Mycobacterium tuberculosis infection requires il12rb1 expression by rag1-dependent lineages. |
Q34066925 | Ectopic T-bet expression licenses dendritic cells for IL-12-independent priming of type 1 T cells in vitro. |
Q34465675 | Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin |
Q53070548 | Embryonic Fibroblasts Promote Antitumor Cytotoxic Effects of CD8+ T Cells. |
Q81704177 | Endothelial inducible costimulator ligand expression is increased during human cardiac allograft rejection and regulates endothelial cell-dependent allo-activation of CD8+ T cells in vitro |
Q50582511 | Endothelial injury in transplant glomerulopathy is correlated with transcription factor T-bet expression. |
Q47259954 | Eomesodermin Increases Survival and IL-2 Responsiveness of Tumor-specific CD8+ T Cells in an Adoptive Transfer Model of Cancer Immunotherapy |
Q38805222 | Eomesodermin promotes interferon-γ expression and binds to multiple conserved noncoding sequences across the Ifng locus in mouse thymoma cell lines |
Q59356682 | Etiology of increased cancer incidence after solid organ transplantation |
Q41003777 | Ex vivo lymphocyte phenotyping during Plasmodium falciparum sporozoite immunization in humans |
Q51997998 | Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules. |
Q55210585 | Exposure of Human CD8+ T Cells to Type-2 Cytokines Impairs Division and Differentiation and Induces Limited Polarization. |
Q36229707 | Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation. |
Q46095689 | FOXO1 opposition of CD8+ T cell effector programming confers early memory properties and phenotypic diversity |
Q92071354 | Functional Differences Between EBV- and CMV-Specific CD8+ T cells Demonstrate Heterogeneity of T cell Dysfunction in CLL |
Q40101568 | GSK 3 inhibition drives maturation of NK cells and enhances their antitumor activity |
Q33585243 | Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma |
Q33946269 | Gene regulation and chromatin remodeling by IL-12 and type I IFN in programming for CD8 T cell effector function and memory |
Q37764002 | Generating diversity: transcriptional regulation of effector and memory CD8 T-cell differentiation |
Q37259809 | Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells |
Q49748869 | HIV-Specific CD8+ T Cells Exhibit Reduced and Differentially Regulated Cytolytic Activity in Lymphoid Tissue |
Q35166674 | Heteroclitic XBP1 peptides evoke tumor-specific memory cytotoxic T lymphocytes against breast cancer, colon cancer, and pancreatic cancer cells |
Q42201478 | High eomesodermin expression among CD57+ CD8+ T cells identifies a CD8+ T cell subset associated with viral control during chronic human immunodeficiency virus infection |
Q34784615 | Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). |
Q37247908 | Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development |
Q35596351 | IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions |
Q33755642 | IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis |
Q36625910 | IL-2 produced by CD8+ immune T cells can augment their IFN-γ production independently from their proliferation in the secondary response to an intracellular pathogen |
Q36403717 | IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. |
Q27304738 | IL-2 sensitivity and exogenous IL-2 concentration gradient tune the productive contact duration of CD8(+) T cell-APC: a multiscale modeling study |
Q37228165 | IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis |
Q64120462 | IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling |
Q42017438 | Id2 influences differentiation of killer cell lectin-like receptor G1(hi) short-lived CD8+ effector T cells |
Q36007570 | Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals. |
Q38011227 | Immune response to CMV in solid organ transplant recipients: current concepts and future directions |
Q38918131 | Immunosurveillance of lung melanoma metastasis in EBI-3-deficient mice mediated by CD8+ T cells |
Q30365379 | Impaired heterologous immunity in aged ferrets during sequential influenza A H1N1 infection. |
Q34870550 | Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression |
Q37157967 | Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa |
Q53625179 | Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet. |
Q35235677 | Increased expression of peripheral blood leukocyte genes implicate CD14+ tissue macrophages in cellular intestine allograft rejection. |
Q34066709 | Inflammation programs self-reactive CD8+ T cells to acquire T-box-mediated effector function but does not prevent deletional tolerance |
Q33936084 | Inflammatory cytokines as a third signal for T cell activation |
Q36132841 | Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells |
Q37594928 | Interferon-Alpha Promotes Th1 Response and Epithelial Apoptosis via Inflammasome Activation in Human Intestinal Mucosa |
Q42251342 | Interleukin-21 and cellular activation concurrently induce potent cytotoxic function and promote antiviral activity in human CD8 T cells |
Q35152154 | Intralesional delivery of dendritic cells engineered to express T-bet promotes protective type 1 immunity and the normalization of the tumor microenvironment. |
Q37217375 | Intrinsic and extrinsic control of effector T cell survival and memory T cell development |
Q40170834 | JNK2 negatively regulates CD8+ T cell effector function and anti-tumor immune response |
Q96293617 | Jigsaw falling into place: A review and perspective of lymphoid tissue CD8+ T cells and control of HIV |
Q38930056 | Knockdown of T-bet expression in Mart-127-35 -specific T-cell-receptor-engineered human CD4(+) CD25(-) and CD8(+) T cells attenuates effector function |
Q36924962 | Lineage-specific transcription factors in unexpected places. |
Q26830915 | Linking obesity with type 2 diabetes: the role of T-bet |
Q27315106 | Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread |
Q57462291 | Loss of T-bet confers survival advantage to influenza-bacterial superinfection |
Q79561519 | Lung pathology and immediate hypersensitivity in a mouse model after vaccination with pertussis vaccines and challenge with Bordetella pertussis |
Q98665173 | Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy |
Q92378022 | Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion |
Q50087578 | Mechanisms of CD8+ T cell-mediated suppression of HIV/SIV replication. |
Q47562656 | Memory T Cell Proliferation before Hepatitis C Virus Therapy Predicts Antiviral Immune Responses and Treatment Success. |
Q93052264 | Microenvironment-Dependent Gradient of CTL Exhaustion in the AE17sOVA Murine Mesothelioma Tumor Model |
Q38872550 | Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania |
Q64230493 | Model-Based Assessment of the Role of Uneven Partitioning of Molecular Content on Heterogeneity and Regulation of Differentiation in CD8 T-Cell Immune Responses |
Q37802429 | Molecular mechanisms by which T‐bet regulates T‐helper cell commitment |
Q35178738 | More than just a T-box: the role of T-bet as a possible biomarker and therapeutic target in autoimmune diseases. |
Q55428481 | Multiple Regulatory Levels of Growth Arrest-Specific 6 in Mucosal Immunity Against an Oral Pathogen. |
Q33281042 | NF-kappaB-regulated suppression of T-bet in T cells represses Th1 immune responses in pregnancy |
Q35557349 | No evidence for activation of T(H)1 or T(H)17 pathways in unstimulated peripheral blood mononuclear cells from children with β-cell autoimmunity or T1D. |
Q36528999 | Not-so-great expectations: re-assessing the essence of T-cell memory. |
Q35762439 | Novel ChIP-based strategies to uncover transcription factor target genes in the immune system |
Q52668712 | PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity. |
Q36035295 | Pathologic and Protective Roles for Microglial Subsets and Bone Marrow- and Blood-Derived Myeloid Cells in Central Nervous System Inflammation |
Q33539769 | Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells |
Q37832385 | Phenotypical and functional specialization of FOXP3+ regulatory T cells |
Q37763999 | Plasticity in programming of effector and memory CD8 T-cell formation |
Q35463623 | Primary cytomegalovirus phosphoprotein 65-specific CD8+ T-cell responses and T-bet levels predict immune control during early chronic infection in lung transplant recipients |
Q35934180 | Recent developments in the transcriptional regulation of cytolytic effector cells |
Q94503527 | Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion |
Q37209054 | Reciprocal responsiveness to interleukin-12 and interferon-alpha specifies human CD8+ effector versus central memory T-cell fates |
Q26825247 | Regulating the immune system via IL-15 transpresentation |
Q38165191 | Regulation of antiviral CD8 T-cell responses |
Q37748069 | Regulation of gene expression in peripheral T cells by Runx transcription factors |
Q37603286 | Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes |
Q28256001 | Regulation of interferon-gamma during innate and adaptive immune responses |
Q45163749 | Rescue of Tolerant CD8+ T Cells during Cancer Immunotherapy with IL2:Antibody Complexes |
Q37261196 | Restraint stress modulates virus specific adaptive immunity during acute Theiler's virus infection |
Q37061865 | Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs |
Q36487384 | SLAT regulates CD8+ T cell clonal expansion in a Cdc42- and NFAT1-dependent manner |
Q34059593 | STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge |
Q33756678 | Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation |
Q33771963 | Shaping successful and unsuccessful CD8 T cell responses following infection |
Q37150584 | Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells |
Q34345332 | Signal 3 cytokines as modulators of primary immune responses during infections: the interplay of type I IFN and IL-12 in CD8 T cell responses. |
Q41935260 | Signals that drive T-bet expression in B cells |
Q81578755 | Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells |
Q37117568 | T cell homeostasis. |
Q42727084 | T cell responses: naive to memory and everything in between |
Q36487216 | T cell vaccinology: exploring the known unknowns |
Q36090198 | T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses |
Q36654128 | T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production. |
Q40980505 | T-bet Is Required for the Rapid Clearance of Attenuated Rabies Virus from Central Nervous System Tissue |
Q38315915 | T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects |
Q36399438 | T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes |
Q36667205 | T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis. |
Q43065520 | T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation |
Q36503790 | T-bet expression in CD8+ T cells associated with chronic hepatitis B virus infection |
Q52936581 | T-bet expression patterns in coeliac disease, cryptic and overt enteropathy-type T-cell lymphoma. |
Q37891668 | T-bet in disease. |
Q42094910 | T-bet is required for protection against vaccinia virus infection |
Q36228767 | T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17 |
Q37006604 | T-bet plays a key role in NK-mediated control of melanoma metastatic disease |
Q37713253 | T-bet regulates immunity to Francisella tularensis live vaccine strain infection, particularly in lungs |
Q47765721 | T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells |
Q92383042 | T-bet+ memory B cells: Generation, function, and fate |
Q37320399 | T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function |
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Q41877294 | T-bet-mediated differentiation of the activated CD8+ T cell |
Q38151473 | T-bet: a bridge between innate and adaptive immunity. |
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