RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation

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RNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation is …
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scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...864946H
P356DOI10.1371/JOURNAL.PONE.0064946
P932PMC publication ID3688709
P698PubMed publication ID23840313
P5875ResearchGate publication ID248385407

P2093author name stringLin T Guey
Juan Zhao
Steven Haney
Shiwani Tiwari
Eric Tien
Kurt Eng
P2860cites workAtorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemiaQ85324637
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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
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Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in miceQ28508971
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Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesisQ46570519
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Cdk5 regulates cell-matrix and cell-cell adhesion in lens epithelial cellsQ78001715
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AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascadeQ28511813
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Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicityQ28571130
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolismQ28594811
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetesQ29417138
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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levelsQ29547214
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Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathwayQ33993073
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Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance studyQ35606593
Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survivalQ35613392
Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetesQ36109128
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A-kinase anchoring proteins take shapeQ36463252
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Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2Q36786810
An unusual member of the Cdk family: Cdk5.Q37053631
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight lossQ37105351
CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytesQ37396105
Cdk5, the multifunctional surveyorQ37671505
General review on in vitro hepatocyte models and their applicationsQ37774289
Mechanisms of protein kinase A anchoringQ37783810
Analysis of CaM-kinase signaling in cellsQ37870268
Extraneuronal activities and regulatory mechanisms of the atypical cyclin-dependent kinase Cdk5.Q38026308
Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1.Q39427414
Cdk5-dependent regulation of glucose-stimulated insulin secretion.Q40374920
Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1.Q40572878
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesisQ41791624
A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic controlQ41922145
The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNAQ42244088
Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemiaQ43282888
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesCellProfilerQ5058134
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectgenome-wide association studyQ1098876
type 2 diabetesQ3025883
P304page(s)e64946
P577publication date2013-06-20
P1433published inPLOS OneQ564954
P1476titleRNAi screening in primary human hepatocytes of genes implicated in genome-wide association studies for roles in type 2 diabetes identifies roles for CAMK1D and CDKAL1, among others, in hepatic glucose regulation
P478volume8

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Q38632403Contribution of independent and pleiotropic genetic effects in the metabolic syndrome in a hypertensive rat.
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Q36536523Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
Q47589530High-Content Screening Approaches That Minimize Confounding Factors in RNAi, CRISPR, and Small Molecule Screening
Q34165822Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus
Q37378643Maternal Obesity in Pregnancy Developmentally Programs Adipose Tissue Inflammation in Young, Lean Male Mice Offspring
Q38600595miRNAs: early prognostic biomarkers for Type 2 diabetes mellitus?

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