A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis

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A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis is …
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scholarly articleQ13442814

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P819ADS bibcode2011PNAS..108.5765S
P356DOI10.1073/PNAS.1018012108
P932PMC publication ID3078351
P698PubMed publication ID21436051
P5875ResearchGate publication ID50850465

P50authorAaron L. SarverQ114401680
David A LargaespadaQ114401688
Adam J. DupuyQ55283668
Timothy K StarrQ56427377
P2093author name stringLei Zhao
Robert T Cormier
M Gerard O'Sullivan
Patricia M Scott
Benjamin M Marsh
Bich L N Than
P2860cites workHuman Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcriptionQ24293751
Evidence for a colorectal cancer susceptibility locus on chromosome 3q21-q24 from a high-density SNP genome-wide linkage scanQ56437172
The multiple personalities of AlixQ58298858
Loss of Apc+ in intestinal adenomas from Min miceQ72789835
Evidence that genetic instability occurs at an early stage of colorectal tumorigenesisQ73548893
Stage-specific alterations of the genome, transcriptome, and proteome during colorectal carcinogenesisQ79252702
Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomasQ79401919
Estrogen receptors alpha and beta are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ miceQ79856380
Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3Q24317030
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A transposon-based genetic screen in mice identifies genes altered in colorectal cancerQ24655169
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The APC gene in colorectal cancerQ28215883
Colorectal cancer: genetics of development and metastasisQ28240136
APC mutations occur early during colorectal tumorigenesisQ28274764
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patientsQ28300256
Inactivation of both APC alleles in human and mouse tumorsQ28587902
Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesisQ28593625
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouseQ29616489
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC geneQ29616490
Transcription start regions in the human genome are favored targets for MLV integrationQ29618456
Intestinal adenomas can develop with a stable karyotype and stable microsatellitesQ34066329
Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysisQ34082534
Disease model: familial adenomatous polyposisQ34343422
Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouseQ34344768
Allelotype of colorectal carcinomasQ34461209
In vivo footprinting of a muscle specific enhancer by ligation mediated PCR.Q34550385
Genetic and epigenetic alterations in colon cancerQ34762615
Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cellsQ36105573
A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in miceQ36980093
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.Q37266967
Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) miceQ37329192
Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex.Q37527117
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouseQ42812392
Chromosome copy number analysis in screening for prognosis-related genomic regions in colorectal carcinomaQ44868614
Tissue-specific and inducible Cre-mediated recombination in the gut epitheliumQ44999476
Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice.Q51794711
Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations.Q51970952
A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.Q52548391
High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization.Q53370271
Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors.Q53455477
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectpolyposisQ2103081
Sleeping Beauty transposon systemQ7539848
P304page(s)5765-5770
P577publication date2011-03-21
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleA Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis
P478volume108

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