Ex Vivo Transposon-Mediated Genetic Screens for Cancer Gene Discovery

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Ex Vivo Transposon-Mediated Genetic Screens for Cancer Gene Discovery is …
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P356DOI10.1007/978-1-4939-8967-6_12
P932PMC publication ID6296821
P698PubMed publication ID30542998

P50authorShruthy SureshQ90445208
P2093author name stringKathryn A O'Donnell
Barrett L Updegraff
Xiaorong Zhou
Yabin Guo
P2860cites workThe utility of transposon mutagenesis for cancer studies in the era of genome editingQ26781762
Janus kinase deregulation in leukemia and lymphomaQ26991810
Ba/F3 cells and their use in kinase drug discoveryQ33264919
Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl proteinQ33682660
Novel molecular and computational methods improve the accuracy of insertion site analysis in Sleeping Beauty-induced tumorsQ34023887
Interleukin-3 receptor in acute leukemiaQ34283145
The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signalingQ34304678
A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesisQ34804602
Cell of origin strongly influences genetic selection in a mouse model of T-ALLQ35525387
Therapeutically Targetable ALK Mutations in LeukemiaQ35676273
Clonal selection drives genetic divergence of metastatic medulloblastomaQ35784926
A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.Q35991536
An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis modelQ35995227
Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemiaQ36174146
Transposon-mediated mutagenesis in somatic cells: identification of transposon-genomic DNA junctionsQ36455108
Hematopoietic cytokine receptor signalingQ36970188
Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethalityQ37407179
Sleeping Beauty mutagenesis: exploiting forward genetic screens for cancer gene discoveryQ38198428
Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis.Q38811161
Human somatic cell mutagenesis creates genetically tractable sarcomasQ38965395
Activating alleles of JAK3 in acute megakaryoblastic leukemiaQ40255542
Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cellsQ40895260
Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in miceQ41959338
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouseQ42812392
Interleukin-3 supports growth of mouse pre-B-cell clones in vitroQ52829763
Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.Q53356315
Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo.Q54447711
Hemopoietic growth factor receptor abnormalities in leukemiaQ62819873
Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon systemQ81251466
P407language of work or nameEnglishQ1860
P921main subjectgene discoveryQ129262352
P304page(s)145-157
P577publication date2019-01-01
P1433published inMethods in Molecular BiologyQ15752859
P1476titleEx Vivo Transposon-Mediated Genetic Screens for Cancer Gene Discovery
P478volume1907

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