Therapeutically Targetable ALK Mutations in Leukemia

scientific article published on June 2015

Therapeutically Targetable ALK Mutations in Leukemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/0008-5472.CAN-14-1576
P932PMC publication ID4453002
P698PubMed publication ID26032424

P50authorBrian DrukerQ373427
Bill H. ChangQ55292616
P2093author name stringChristopher A Eide
Jeffrey W Tyner
Daniel Bottomly
Shannon K McWeeney
Julia E Maxson
Marc M Loriaux
Samuel B Luty
Beth Wilmot
Cristina E Tognon
Monika A Davare
P2860cites workDiscovery of tissue-specific exons using comprehensive human exon microarraysQ21092870
Anaplastic lymphoma kinase: signalling in development and diseaseQ24312329
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancerQ27851410
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphomaQ27851421
Activating mutations in ALK provide a therapeutic target in neuroblastomaQ27851452
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.Q27851590
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysisQ27851671
Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CMLQ27852275
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.Q27852316
Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell deathQ28202067
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphomaQ28250347
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemiaQ29615735
A framework for oligonucleotide microarray preprocessing.Q34149103
Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.Q34938204
Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer.Q35166315
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.Q35575978
Anaplastic lymphoma kinase in human cancerQ37866541
RANBP2-ALK fusion combined with monosomy 7 in acute myelomonocytic leukemia.Q38194730
Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic targetQ38326252
Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma.Q39411416
A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogasterQ41008377
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,Q42710837
GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancersQ43262263
ALK fusion genes in children with atypical myeloproliferative leukemiaQ84127631
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)2146-2150
P577publication date2015-06-01
P1433published inCancer ResearchQ326097
P1476titleTherapeutically Targetable ALK Mutations in Leukemia
P478volume75

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cites work (P2860)
Q38701797ALK-positive large B-cell lymphoma: identification of EML4-ALK and a review of the literature focusing on the ALK immunohistochemical staining pattern
Q38616826Anaplastic Lymphoma Kinase as a Cancer Target in Pediatric Malignancies
Q37254729Crizotinib treatment for refractory pediatric acute myeloid leukemia with RAN-binding protein 2-anaplastic lymphoma kinase fusion gene
Q60923199Ex Vivo Transposon-Mediated Genetic Screens for Cancer Gene Discovery
Q38636162Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies.
Q26746934Targeted Therapies for the Treatment of Pediatric Non-Hodgkin Lymphomas: Present and Future