| scholarly article | Q13442814 |
| review article | Q7318358 |
| P356 | DOI | 10.1002/MED.10016 |
| P698 | PubMed publication ID | 12210555 |
| P2093 | author name string | Paul D Roepe | |
| Lyann M B Ursos | |||
| P2860 | cites work | Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line | Q24338329 |
| On the molecular mechanism of chloroquine's antimalarial action | Q24603529 | ||
| Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum | Q27861931 | ||
| A Plasmodium falciparum aminopeptidase gene belonging to the M1 family of zinc-metallopeptidases is expressed in erythrocytic stages | Q27973829 | ||
| Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance | Q29615118 | ||
| Identification and characterization of falcilysin, a metallopeptidase involved in hemoglobin catabolism within the malaria parasite Plasmodium falciparum | Q30042132 | ||
| Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease | Q30045945 | ||
| Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum | Q31000158 | ||
| A molecular marker for chloroquine-resistant falciparum malaria | Q31921233 | ||
| Are ion-exchange processes central to understanding drug-resistance phenomena? | Q33547894 | ||
| What is the precise role of human MDR 1 protein in chemotherapeutic drug resistance? | Q33818567 | ||
| The structure of malaria pigment beta-haematin | Q33896881 | ||
| Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America | Q33948012 | ||
| Chloroquine-resistant malaria | Q34087800 | ||
| A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum | Q35592776 | ||
| Malaria pigment | Q36095800 | ||
| Differential stimulation of the Na+/H+ exchanger determines chloroquine uptake in Plasmodium falciparum | Q36254819 | ||
| Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance? | Q36435761 | ||
| Quinoline-containing antimalarials—mode of action, drug resistance and its reversal an update with unresolved puzzles | Q36755885 | ||
| An iron-carboxylate bond links the heme units of malaria pigment | Q37366154 | ||
| Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7. | Q37485888 | ||
| Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine | Q37559063 | ||
| The composition of haemozoin from Plasmodium falciparum | Q38881672 | ||
| Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum. | Q38920326 | ||
| Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand | Q39596627 | ||
| Chloroquine Resistance in Malaria: Accessibility of Drug Receptors to Mefloquine | Q40619996 | ||
| 4-Aminoquinolines--past, present, and future: a chemical perspective | Q40866974 | ||
| A comparison of the phenomenology and genetics of multidrug resistance in cancer cells and quinoline resistance in Plasmodium falciparum | Q40866979 | ||
| Altered drug translocation mediated by the MDR protein: direct, indirect, or both? | Q41254848 | ||
| Evidence for electrogenic accumulation of mefloquine by malarial parasites | Q41424325 | ||
| Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound | Q41435053 | ||
| Recent studies of the mineral phase in bone and its possible linkage to the organic matrix by protein-bound phosphate bonds | Q41535606 | ||
| The dimerization of ferrihaems. IV. Studies on haematoferrihaem and a general appraisal of the nature and implications of dimerization | Q41608283 | ||
| Plasmodium lophurae: Composition and properties of hemozoin, the malarial pigment | Q41680586 | ||
| Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum | Q41745894 | ||
| Dissociation of aggregated ferroheme complexes and protoporphyrin IX by water-soluble polymers | Q41889155 | ||
| Uptake of [3H]chloroquine by drug-sensitive and -resistant strains of the human malaria parasite Plasmodium falciparum | Q41914857 | ||
| Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum | Q41918212 | ||
| Haemoproteus and Schistosoma synthesize heme polymers similar to Plasmodium hemozoin and beta-hematin | Q41920115 | ||
| The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine | Q41921086 | ||
| Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine | Q41921094 | ||
| Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum | Q41921101 | ||
| Metalloporphyrins inhibit beta-hematin (hemozoin) formation | Q41921871 | ||
| P. falciparum CG2, linked to chloroquine resistance, does not resemble Na+/H+ exchangers | Q41925822 | ||
| An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials | Q41926615 | ||
| Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa | Q41927511 | ||
| Non-iron porphyrins inhibit beta-haematin (malaria pigment) polymerisation. | Q41928261 | ||
| The role of drug accumulation in 4-aminoquinoline antimalarial potency. The influence of structural substitution and physicochemical properties. | Q41930125 | ||
| Verapamil Reversal of Chloroquine Resistance in the Malaria Parasite Plasmodium falciparum Is Specific for Resistant Parasites and Independent of the Weak Base Effect | Q41932457 | ||
| Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein | Q41933334 | ||
| Effects of antimalarials and protease inhibitors on plasmodial hemozoin production | Q41934587 | ||
| Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment). | Q41934645 | ||
| Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites | Q41940707 | ||
| Morphological Effects of Chloroquine on Plasmodium berghei in Mice | Q41941252 | ||
| Kinetic modelling of chloroquine uptake by malaria-infected erythrocytes. Assessment of the factors that may determine drug resistance | Q41942038 | ||
| Kinetic modelling of the response of Plasmodium falciparum to chloroquine and its experimental testing in vitro. Implications for mechanism of action of and resistance to the drug | Q41943516 | ||
| Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross | Q41943911 | ||
| Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum | Q41945692 | ||
| The structure of haem in pyridine/water mixtures and its implication in studies of haem catabolism | Q42916671 | ||
| The chemical mechanism of beta-haematin formation studied by Mössbauer spectroscopy | Q42983304 | ||
| Aminopeptidases from Plasmodium falciparum, Plasmodium chabaudi chabaudi and Plasmodium berghei | Q43023116 | ||
| The mechanism of beta-hematin formation in acetate solution. Parallels between hemozoin formation and biomineralization processes | Q43515904 | ||
| Characterization of the malaria pigment (hemozoin) from the avian malaria parasite Plasmodium lophurae | Q47700805 | ||
| Spectroscopic characterization of the heme-binding sites in Plasmodium falciparum histidine-rich protein 2. | Q47857044 | ||
| Haem polymerization in malaria | Q47998079 | ||
| Generation of hemoglobin peptides in the acidic digestive vacuole of Plasmodium falciparum implicates peptide transport in amino acid production | Q48037131 | ||
| Is the putative chloroquine resistance mediator CG2 the Na+/H+ exchanger of Plasmodium falciparum? | Q48039692 | ||
| Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena. | Q54022381 | ||
| Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein. | Q54228550 | ||
| Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of P-glycoprotein | Q54255630 | ||
| P433 | issue | 5 | |
| P921 | main subject | malaria | Q12156 |
| Plasmodium falciparum | Q311383 | ||
| chloroquine | Q422438 | ||
| P304 | page(s) | 465-491 | |
| P577 | publication date | 2002-09-01 | |
| P1433 | published in | Medicinal Research Reviews | Q2436033 |
| P1476 | title | Chloroquine resistance in the malarial parasite, Plasmodium falciparum | |
| P478 | volume | 22 |
| Q41772843 | 4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria |
| Q41912137 | A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance. |
| Q34686526 | A whole cell pathway screen reveals seven novel chemosensitizers to combat chloroquine resistant malaria |
| Q41916876 | Analysis of the antimalarial drug resistance protein Pfcrt expressed in yeast |
| Q35790381 | Antimalarial drug discovery: efficacy models for compound screening |
| Q41900287 | Assessment of malaria in vitro drug combination screening and mixed-strain infections using the malaria Sybr green I-based fluorescence assay |
| Q41915698 | Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter. |
| Q92013843 | Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates |
| Q41943028 | Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum |
| Q41913720 | Evidence for activation of endogenous transporters in Xenopus laevis oocytes expressing the Plasmodium falciparum chloroquine resistance transporter, PfCRT. |
| Q60187324 | Expanding the SAR of Nontoxic Antiplasmodial Indolyl-3-ethanone Ethers and Thioethers |
| Q24648954 | Hemozoin: oil versus water |
| Q37717358 | In vitro studies on the sensitivity pattern of Plasmodium falciparum to anti-malarial drugs and local herbal extracts |
| Q37299770 | Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria |
| Q56380665 | Novel Peroxides as Promising Anticancer Agents with Unexpected Depressed Antimalarial Activity |
| Q36888033 | Overcoming Chloroquine Resistance in Malaria: Design, Synthesis, and Structure-Activity Relationships of Novel Hybrid Compounds |
| Q41915835 | Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization and antimalarial properties |
| Q35069586 | PfCRT-mediated drug transport in malarial parasites |
| Q39719066 | Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology |
| Q41943323 | Quantitative pH measurements in Plasmodium falciparum-infected erythrocytes using pHluorin |
| Q34128946 | Ruthenium(II) arene complexes with chelating chloroquine analogue ligands: synthesis, characterization and in vitro antimalarial activity |
| Q35484126 | Screening of different extracts from artemisia species for their potential antimalarial activity |
| Q42857134 | Synthesis of new 4-aminoquinolines and quinoline–acridine hybrids as antimalarial agents |
| Q31102032 | The novel antimalarial compound dioncophylline C forms a complex with heme in solution |
| Q34151405 | Transporters involved in resistance to antimalarial drugs. |
| Q90914855 | Unpacking the Pathogen Box-An Open Source Tool for Fighting Neglected Tropical Disease |
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