review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | Gregg G Gundersen | |
Howard J Worman | |||
Wakam Chang | |||
P2860 | cites work | Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds | Q21134152 |
Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy | Q22009039 | ||
Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction | Q22254386 | ||
Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues | Q24292172 | ||
Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle | Q24292752 | ||
Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. | Q24296713 | ||
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleus | Q24297804 | ||
Coupling of the nucleus and cytoplasm: role of the LINC complex | Q24299991 | ||
Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro | Q24303760 | ||
Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy | Q24317622 | ||
Patterns of evolutionary conservation in the nesprin genes highlight probable functionally important protein domains and isoforms | Q40026432 | ||
Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin | Q40078237 | ||
Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity | Q40087014 | ||
Telomere-led bouquet formation facilitates homologous chromosome pairing and restricts ectopic interaction in fission yeast meiosis | Q40430228 | ||
A kinesin-mediated mechanism that couples centrosomes to nuclei | Q41307515 | ||
A network of nuclear envelope membrane proteins linking centromeres to microtubules | Q42044145 | ||
Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins | Q42633412 | ||
Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1. | Q43242461 | ||
Novel clinically relevant genes in gastrointestinal stromal tumors identified by exome sequencing | Q43642622 | ||
A family of zinc-finger proteins is required for chromosome-specific pairing and synapsis during meiosis in C. elegans. | Q45933828 | ||
Nesprin interchain associations control nuclear size | Q47306531 | ||
Myosin XI-i links the nuclear membrane to the cytoskeleton to control nuclear movement and shape in Arabidopsis. | Q47712889 | ||
Association at SYNE1 in both bipolar disorder and recurrent major depression | Q47796306 | ||
A novel fission yeast gene, kms1+, is required for the formation of meiotic prophase-specific nuclear architecture | Q48051024 | ||
Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia | Q48341636 | ||
SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. | Q51984300 | ||
Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes. | Q53627503 | ||
Inner nuclear membrane protein Ima1 is dispensable for intranuclear positioning of centromeres | Q57228984 | ||
Mutation of SYNE-1, encoding an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposis | Q84096029 | ||
LINC complex alterations in DMD and EDMD/CMT fibroblasts | Q24318534 | ||
Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes | Q24319820 | ||
Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarization | Q24320152 | ||
LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins | Q24336621 | ||
Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarization | Q24338445 | ||
Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin | Q24679428 | ||
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy | Q24681029 | ||
The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin | Q27314937 | ||
The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse | Q27324691 | ||
Structural insights into SUN-KASH complexes across the nuclear envelope | Q27671858 | ||
Structure of Sad1-UNC84 Homology (SUN) Domain Defines Features of Molecular Bridge in Nuclear Envelope | Q27676189 | ||
The consensus coding sequences of human breast and colorectal cancers | Q27861035 | ||
Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis | Q27931634 | ||
Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination | Q27932760 | ||
MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae | Q27939239 | ||
Samp1 is functionally associated with the LINC complex and A-type lamina networks | Q28114980 | ||
Mammalian microtubule P-body dynamics are mediated by nesprin-1. | Q28118582 | ||
The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus | Q28236367 | ||
Nuclei take a position: managing nuclear location | Q28265118 | ||
The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope | Q28265573 | ||
FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement | Q28505650 | ||
Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells | Q28508708 | ||
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice | Q28509255 | ||
Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton | Q28511078 | ||
A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis | Q28511474 | ||
Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization | Q28542922 | ||
Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope | Q28582179 | ||
Dystonin/Bpag1 is a necessary endoplasmic reticulum/nuclear envelope protein in sensory neurons | Q28586388 | ||
Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope | Q28587115 | ||
A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton | Q28590832 | ||
Samp1 is a component of TAN lines and is required for nuclear movement | Q28591580 | ||
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations | Q29614573 | ||
Using whole-exome sequencing to identify inherited causes of autism | Q30418126 | ||
The LINC complex is essential for hearing | Q30458666 | ||
Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement. | Q30497830 | ||
The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeleton | Q30502842 | ||
Microtubule-organizing center formation at telomeres induces meiotic telomere clustering | Q30536165 | ||
Emerin organizes actin flow for nuclear movement and centrosome orientation in migrating fibroblasts | Q30559349 | ||
The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture | Q30584661 | ||
Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein | Q33112261 | ||
Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis. | Q33674350 | ||
UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration | Q33677404 | ||
Identification of unique SUN-interacting nuclear envelope proteins with diverse functions in plants | Q33731253 | ||
Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges. | Q33739566 | ||
Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency. | Q33740216 | ||
ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium study | Q33824208 | ||
Structural insights into LINC complexes | Q33829427 | ||
Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus. | Q33859070 | ||
Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans | Q34011754 | ||
A role for nuclear envelope-bridging complexes in homology-directed repair | Q34081445 | ||
The Caenorhabditis elegans SUN protein UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration | Q34166897 | ||
Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei | Q34191608 | ||
Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope. | Q34251384 | ||
Nuclear envelope localization of human UNC84A does not require nuclear lamins | Q34489495 | ||
KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development | Q34597805 | ||
Role of ANC-1 in tethering nuclei to the actin cytoskeleton. | Q34647845 | ||
SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton | Q34717324 | ||
Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins | Q34721188 | ||
Estimation of the mechanical connection between apical stress fibers and the nucleus in vascular smooth muscle cells cultured on a substrate. | Q35096669 | ||
POM121 and Sun1 play a role in early steps of interphase NPC assembly | Q35102437 | ||
Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons | Q35579834 | ||
Dynein-dependent processive chromosome motions promote homologous pairing in C. elegans meiosis | Q35666304 | ||
Novel plant SUN-KASH bridges are involved in RanGAP anchoring and nuclear shape determination | Q35694171 | ||
Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells | Q35835899 | ||
Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure | Q35964554 | ||
Functional association of Sun1 with nuclear pore complexes | Q36119056 | ||
Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response | Q36303518 | ||
Nuclear positioning | Q36765676 | ||
Meiotic chromosomes move by linkage to dynamic actin cables with transduction of force through the nuclear envelope | Q37013008 | ||
Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery | Q37175976 | ||
UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration. | Q37314398 | ||
Nuclear mechanics and mechanotransduction in health and disease | Q37444772 | ||
Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix | Q37596116 | ||
The SUN rises on meiotic chromosome dynamics | Q37634706 | ||
SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown | Q37677592 | ||
TAN lines: a novel nuclear envelope structure involved in nuclear positioning | Q37912001 | ||
Nuclear lamins and laminopathies. | Q37939691 | ||
The meiosis-specific modification of mammalian telomeres. | Q38215586 | ||
Functional architecture of the cell's nucleus in development, aging, and disease | Q38221682 | ||
Nesprin-1 role in DNA damage response | Q39000180 | ||
The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction. | Q39207439 | ||
A truncated lamin A in the Lmna -/- mouse line: implications for the understanding of laminopathies | Q39297135 | ||
Dynamic properties of meiosis-specific lamin C2 and its impact on nuclear envelope integrity | Q39590939 | ||
Nesprin-1 mutations in human and murine cardiomyopathy | Q39599077 | ||
Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope. | Q39648077 | ||
Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation. | Q39782824 | ||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | mechanotransduction | Q11936292 |
cell | Q7868 | ||
nucleus | Q40260 | ||
macromolecular substance | Q75174158 | ||
P1104 | number of pages | 12 | |
P304 | page(s) | 11-22 | |
P577 | publication date | 2015-01-01 | |
2015-01-05 | |||
P1433 | published in | Journal of Cell Biology | Q1524550 |
P1476 | title | Accessorizing and anchoring the LINC complex for multifunctionality | |
P478 | volume | 208 |
Q30673640 | 53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair |
Q92038784 | Ablation of SUN2-containing LINC complexes drives cardiac hypertrophy without interstitial fibrosis |
Q40998990 | Actomyosin and vimentin cytoskeletal networks regulate nuclear shape, mechanics and chromatin organization |
Q42200089 | Aged induced pluripotent stem cell (iPSCs) as a new cellular model for studying premature aging |
Q38872804 | An unresolved LINC in the nuclear envelope |
Q100466498 | Apoptotic stress induces Bax-dependent, caspase-independent redistribution of LINC complex nesprins |
Q52311011 | Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms. |
Q51736887 | Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture. |
Q39174882 | Bursting the Bubble - Nuclear Envelope Rupture as a Path to Genomic Instability? |
Q48165276 | Bypassing Border Control: Nuclear Envelope Rupture in Disease. |
Q36008889 | Cell Microharpooning to Study Nucleo-Cytoskeletal Coupling |
Q49497261 | Centrifugal Displacement of Nuclei Reveals Multiple LINC Complex Mechanisms for Homeostatic Nuclear Positioning |
Q61805006 | Chain reaction: LINC complexes and nuclear positioning |
Q38971271 | Cytoskeletal Integrators: The Spectrin Superfamily |
Q91786551 | DYT1 Dystonia Patient-Derived Fibroblasts Have Increased Deformability and Susceptibility to Damage by Mechanical Forces |
Q36392451 | Data on the association of the nuclear envelope protein Sun1 with nucleoli |
Q64106731 | Deciphering Nuclear Mechanobiology in Laminopathy |
Q97521265 | Different Proteins Mediate Step-Wise Chromosome Architectures in Thermoplasma acidophilum and Pyrobaculum calidifontis |
Q55344191 | Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression. |
Q47373054 | Differentiation-Dependent Motility-Responses of Developing Neural Progenitors to Optogenetic Stimulation |
Q48355517 | Dynamic Changes in Plant Nuclear Organization in Response to Environmental and Developmental Signals. |
Q38580523 | Dynamic, mechanical integration between nucleus and cell- where physics meets biology |
Q90841072 | Electron tomography of mouse LINC complexes at meiotic telomere attachment sites with and without microtubules |
Q52691517 | Emerging views of the nucleus as a cellular mechanosensor. |
Q26766402 | Emery-Dreifuss muscular dystrophy: a test case for precision medicine |
Q38750488 | Fascin Regulates Nuclear Movement and Deformation in Migrating Cells |
Q38804258 | Finding a place in the SUN: telomere maintenance in a diverse nuclear landscape. |
Q52364056 | Fluorescence Fluctuation Spectroscopy Reveals Differential SUN Protein Oligomerization In Living Cells. |
Q36455386 | Forces, fluctuations, and self-organization in the nucleus |
Q47189714 | From Cytoskeleton to Gene Expression: Actin in the Nucleus |
Q26767470 | GIP Contributions to the Regulation of Centromere at the Interface Between the Nuclear Envelope and the Nucleoplasm |
Q39453542 | Identification of novel nesprin-1 binding partners and cytoplasmic matrin-3 in processing bodies |
Q91943122 | Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging |
Q28078956 | Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies |
Q38934333 | Inner nuclear envelope protein SUN1 plays a prominent role in mammalian mRNA export |
Q41785405 | LINCing defective nuclear-cytoskeletal coupling and DYT1 dystonia |
Q48357964 | Lamin A and microtubules collaborate to maintain nuclear morphology |
Q37503436 | Lamin-B1 contributes to the proper timing of epicardial cell migration and function during embryonic heart development |
Q39318399 | Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression |
Q41836884 | Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1. |
Q90632667 | Local, transient tensile stress on the nuclear membrane causes membrane rupture |
Q64120250 | MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation |
Q92910529 | MLKS2 is an ARM domain and F-actin-associated KASH protein that functions in stomatal complex development and meiotic chromosome segregation |
Q91229323 | Mechanical regulation of gene expression in cardiac myocytes and fibroblasts |
Q47205718 | Mechanosensing and fibrosis |
Q47191844 | Mechanotransduction Mechanisms in Mitral Valve Physiology and Disease Pathogenesis. |
Q52323035 | Mechanotransduction via the LINC complex regulates DNA replication in myonuclei. |
Q89603325 | Membrane and organelle dynamics during cell division |
Q47227302 | Messages from the voices within: regulation of signaling by proteins of the nuclear lamina. |
Q60907992 | Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia |
Q50957246 | Mkl1-dependent gene activation is sufficient to induce actin cap assembly. |
Q52355772 | Molecular Insights into the Mechanisms of SUN1 Oligomerization in the Nuclear Envelope. |
Q38720377 | Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets. |
Q91153136 | Nesprin-2G knockout fibroblasts exhibit reduced migration, changes in focal adhesion composition, and reduced ability to generate traction forces |
Q93155735 | Nonmuscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells |
Q36976860 | Nuclear Envelope Retention of LINC Complexes Is Promoted by SUN-1 Oligomerization in the Caenorhabditis elegans Germ Line |
Q37325808 | Nuclear envelope rupture: Actin fibers are putting the squeeze on the nucleus |
Q28083920 | Nuclear envelope: positioning nuclei and organizing synapses |
Q35909029 | Nuclear membrane diversity: underlying tissue-specific pathologies in disease? |
Q28070084 | Nuclear migration events throughout development |
Q37727547 | Nuclear morphologies: their diversity and functional relevance |
Q47292878 | Nuclear positioning in migrating fibroblasts |
Q37573370 | Opposing roles for distinct LINC complexes in regulation of the small GTPase RhoA. |
Q38674896 | Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture. |
Q36428040 | PML isoform II plays a critical role in nuclear lipid droplet formation. |
Q92166503 | PP2A-B55/SUR-6 collaborates with the nuclear lamina for centrosome separation during mitotic entry |
Q64268135 | Pairing of homologous chromosomes in C. elegans meiosis requires DEB-1 - an orthologue of mammalian vinculin |
Q39247023 | Pathways Involved in Formation of Mammary Organoid Architecture Have Keys to Understanding Drug Resistance and to Discovery of Druggable Targets. |
Q51810368 | Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls. |
Q43112067 | Protection of muscle nuclei. |
Q47626666 | Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging. |
Q40096247 | Purification and Structural Analysis of SUN and KASH Domain Proteins |
Q38697490 | Quantitative Brightness Analysis of Protein Oligomerization in the Nuclear Envelope. |
Q42038439 | Reinforcing the LINC complex connection to actin filaments: the role of FHOD1 in TAN line formation and nuclear movement |
Q94483667 | Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus |
Q90347414 | Role of α-Dystrobrevin in the differentiation process of HL-60 cells |
Q36736438 | SUN2 Overexpression Deforms Nuclear Shape and Inhibits HIV. |
Q40375929 | SUN2 Silencing Impairs CD4 T Cell Proliferation and Alters Sensitivity to HIV-1 Infection Independently of Cyclophilin A. |
Q55651799 | Sad1 Spatiotemporally Regulates Kinetochore Clustering To Ensure High-Fidelity Chromosome Segregation in the Human Fungal Pathogen Cryptococcus neoformans. |
Q57461816 | Samp1 Mislocalization in Emery-Dreifuss Muscular Dystrophy |
Q31814825 | Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane |
Q37618935 | Shared mechanisms in physiological and pathological nucleoplasmic reticulum formation |
Q64064296 | Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons |
Q38987148 | Spatial organization of the Schizosaccharomyces pombe genome within the nucleus |
Q36952227 | Squish and squeeze-the nucleus as a physical barrier during migration in confined environments. |
Q36931652 | Targeting Mitogen-Activated Protein Kinase Signaling in Mouse Models of Cardiomyopathy Caused by Lamin A/C Gene Mutations |
Q36229559 | The C-Terminal SynMuv/DdDUF926 Domain Regulates the Function of the N-Terminal Domain of DdNKAP. |
Q91802631 | The Centrosome and the Primary Cilium: The Yin and Yang of a Hybrid Organelle |
Q38748059 | The Malleable Nature of the Budding Yeast Nuclear Envelope: Flares, Fusion, and Fenestrations. |
Q60046863 | The Neutrophil Nucleus: An Important Influence on Neutrophil Migration and Function |
Q39029494 | The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction |
Q33737254 | The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart |
Q41489772 | The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation |
Q90462509 | The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair |
Q38724224 | The nucleus is a conserved mechanosensation and mechanoresponse organelle. |
Q38714582 | TorsinA controls TAN line assembly and the retrograde flow of dorsal perinuclear actin cables during rearward nuclear movement. |
Q39312769 | UNC-84: "LINC-ing" chromosome movement and double strand break repair. |
Q26744459 | Under Pressure: Mechanical Stress Management in the Nucleus |
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