Accessorizing and anchoring the LINC complex for multifunctionality

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Accessorizing and anchoring the LINC complex for multifunctionality is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1083/JCB.201409047
P932PMC publication ID4284225
P698PubMed publication ID25559183
P5875ResearchGate publication ID270652706

P2093author name stringGregg G Gundersen
Howard J Worman
Wakam Chang
P2860cites workMultiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffoldsQ21134152
Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophyQ22009039
Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junctionQ22254386
Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissuesQ24292172
Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscleQ24292752
Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement.Q24296713
The inner nuclear membrane protein emerin regulates beta-catenin activity by restricting its accumulation in the nucleusQ24297804
Coupling of the nucleus and cytoplasm: role of the LINC complexQ24299991
Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitroQ24303760
Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophyQ24317622
Patterns of evolutionary conservation in the nesprin genes highlight probable functionally important protein domains and isoformsQ40026432
Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectinQ40078237
Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrityQ40087014
Telomere-led bouquet formation facilitates homologous chromosome pairing and restricts ectopic interaction in fission yeast meiosisQ40430228
A kinesin-mediated mechanism that couples centrosomes to nucleiQ41307515
A network of nuclear envelope membrane proteins linking centromeres to microtubulesQ42044145
Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteinsQ42633412
Meiotic chromosome homology search involves modifications of the nuclear envelope protein Matefin/SUN-1.Q43242461
Novel clinically relevant genes in gastrointestinal stromal tumors identified by exome sequencingQ43642622
A family of zinc-finger proteins is required for chromosome-specific pairing and synapsis during meiosis in C. elegans.Q45933828
Nesprin interchain associations control nuclear sizeQ47306531
Myosin XI-i links the nuclear membrane to the cytoskeleton to control nuclear movement and shape in Arabidopsis.Q47712889
Association at SYNE1 in both bipolar disorder and recurrent major depressionQ47796306
A novel fission yeast gene, kms1+, is required for the formation of meiotic prophase-specific nuclear architectureQ48051024
Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxiaQ48341636
SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.Q51984300
Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.Q53627503
Inner nuclear membrane protein Ima1 is dispensable for intranuclear positioning of centromeresQ57228984
Mutation of SYNE-1, encoding an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposisQ84096029
LINC complex alterations in DMD and EDMD/CMT fibroblastsQ24318534
Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processesQ24319820
Nesprin 4 is an outer nuclear membrane protein that can induce kinesin-mediated cell polarizationQ24320152
LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteinsQ24336621
Nesprin-3 regulates endothelial cell morphology, perinuclear cytoskeletal architecture, and flow-induced polarizationQ24338445
Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectinQ24679428
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophyQ24681029
The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-CateninQ27314937
The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouseQ27324691
Structural insights into SUN-KASH complexes across the nuclear envelopeQ27671858
Structure of Sad1-UNC84 Homology (SUN) Domain Defines Features of Molecular Bridge in Nuclear EnvelopeQ27676189
The consensus coding sequences of human breast and colorectal cancersQ27861035
Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosisQ27931634
Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombinationQ27932760
MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiaeQ27939239
Samp1 is functionally associated with the LINC complex and A-type lamina networksQ28114980
Mammalian microtubule P-body dynamics are mediated by nesprin-1.Q28118582
The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleusQ28236367
Nuclei take a position: managing nuclear locationQ28265118
The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelopeQ28265573
FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movementQ28505650
Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cellsQ28508708
SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in miceQ28509255
Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeletonQ28511078
A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosisQ28511474
Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organizationQ28542922
Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelopeQ28582179
Dystonin/Bpag1 is a necessary endoplasmic reticulum/nuclear envelope protein in sensory neuronsQ28586388
Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelopeQ28587115
A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeletonQ28590832
Samp1 is a component of TAN lines and is required for nuclear movementQ28591580
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutationsQ29614573
Using whole-exome sequencing to identify inherited causes of autismQ30418126
The LINC complex is essential for hearingQ30458666
Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.Q30497830
The interaction between nesprins and sun proteins at the nuclear envelope is critical for force transmission between the nucleus and cytoskeletonQ30502842
Microtubule-organizing center formation at telomeres induces meiotic telomere clusteringQ30536165
Emerin organizes actin flow for nuclear movement and centrosome orientation in migrating fibroblastsQ30559349
The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architectureQ30584661
Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated proteinQ33112261
Cytoskeletal forces span the nuclear envelope to coordinate meiotic chromosome pairing and synapsis.Q33674350
UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migrationQ33677404
Identification of unique SUN-interacting nuclear envelope proteins with diverse functions in plantsQ33731253
Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges.Q33739566
Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency.Q33740216
ESR1/SYNE1 polymorphism and invasive epithelial ovarian cancer risk: an Ovarian Cancer Association Consortium studyQ33824208
Structural insights into LINC complexesQ33829427
Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus.Q33859070
Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegansQ34011754
A role for nuclear envelope-bridging complexes in homology-directed repairQ34081445
The Caenorhabditis elegans SUN protein UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migrationQ34166897
Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nucleiQ34191608
Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope.Q34251384
Nuclear envelope localization of human UNC84A does not require nuclear laminsQ34489495
KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal developmentQ34597805
Role of ANC-1 in tethering nuclei to the actin cytoskeleton.Q34647845
SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeletonQ34717324
Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteinsQ34721188
Estimation of the mechanical connection between apical stress fibers and the nucleus in vascular smooth muscle cells cultured on a substrate.Q35096669
POM121 and Sun1 play a role in early steps of interphase NPC assemblyQ35102437
Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neuronsQ35579834
Dynein-dependent processive chromosome motions promote homologous pairing in C. elegans meiosisQ35666304
Novel plant SUN-KASH bridges are involved in RanGAP anchoring and nuclear shape determinationQ35694171
Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cellsQ35835899
Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structureQ35964554
Functional association of Sun1 with nuclear pore complexesQ36119056
Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage responseQ36303518
Nuclear positioningQ36765676
Meiotic chromosomes move by linkage to dynamic actin cables with transduction of force through the nuclear envelopeQ37013008
Mechanisms that regulate localization of a DNA double-strand break to the nuclear peripheryQ37175976
UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration.Q37314398
Nuclear mechanics and mechanotransduction in health and diseaseQ37444772
Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrixQ37596116
The SUN rises on meiotic chromosome dynamicsQ37634706
SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdownQ37677592
TAN lines: a novel nuclear envelope structure involved in nuclear positioningQ37912001
Nuclear lamins and laminopathies.Q37939691
The meiosis-specific modification of mammalian telomeres.Q38215586
Functional architecture of the cell's nucleus in development, aging, and diseaseQ38221682
Nesprin-1 role in DNA damage responseQ39000180
The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction.Q39207439
A truncated lamin A in the Lmna -/- mouse line: implications for the understanding of laminopathiesQ39297135
Dynamic properties of meiosis-specific lamin C2 and its impact on nuclear envelope integrityQ39590939
Nesprin-1 mutations in human and murine cardiomyopathyQ39599077
Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope.Q39648077
Novel nuclear nesprin-2 variants tether active extracellular signal-regulated MAPK1 and MAPK2 at promyelocytic leukemia protein nuclear bodies and act to regulate smooth muscle cell proliferation.Q39782824
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectmechanotransductionQ11936292
cellQ7868
nucleusQ40260
macromolecular substanceQ75174158
P1104number of pages12
P304page(s)11-22
P577publication date2015-01-01
2015-01-05
P1433published inJournal of Cell BiologyQ1524550
P1476titleAccessorizing and anchoring the LINC complex for multifunctionality
P478volume208

Reverse relations

cites work (P2860)
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