Squish and squeeze-the nucleus as a physical barrier during migration in confined environments.

scientific article published on 16 February 2016

Squish and squeeze-the nucleus as a physical barrier during migration in confined environments. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CEB.2016.01.011
P932PMC publication ID4887392
P698PubMed publication ID26895141

P50authorJan LammerdingQ48134943
P2093author name stringChieh-Ren Hsia
Alexandra Lynn McGregor
P2860cites workIntravital third harmonic generation microscopy of collective melanoma cell invasion: Principles of interface guidance and microvesicle dynamics.Q55019659
Comparison of neutrophil and capillary diameters and their relation to neutrophil sequestration in the lungQ72913006
Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteinsQ24298586
Coupling of the nucleus and cytoplasm: role of the LINC complexQ24299991
Structural organization of the human gene encoding nuclear lamin A and nuclear lamin CQ24310845
LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteinsQ24336621
When lamins go bad: nuclear structure and diseaseQ26827624
Actomyosin networks and tissue morphogenesisQ27010487
Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion.Q27310111
Chemotaxis of cell populations through confined spaces at single-cell resolutionQ27310963
Continual cell deformation induced via attachment to oriented fibers enhances fibroblast cell migrationQ27312477
Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environmentsQ27334775
Nuclear mechanotransduction: forcing the nucleus to respondQ28085113
Structural organization of the human gene (LMNB1) encoding nuclear lamin B1Q28115157
Tumor cell interactions with the extracellular matrix during invasion and metastasisQ28258256
A perspective on cancer cell metastasisQ28307891
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysisQ29615193
Rapid leukocyte migration by integrin-independent flowing and squeezingQ29620345
Power-law rheology of isolated nuclei with deformation mapping of nuclear substructuresQ30476785
An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environmentsQ30488379
Dynein drives nuclear rotation during forward progression of motile fibroblastsQ30493073
Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cellsQ30498808
Opposing microtubule motors drive robust nuclear dynamics in developing muscle cellsQ30527771
Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction forceQ30540882
Water permeation drives tumor cell migration in confined microenvironmentsQ30629758
Mechanical interplay between invadopodia and the nucleus in cultured cancer cellsQ30633015
Lamin A/C is a risk biomarker in colorectal cancerQ33361579
Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency.Q33740216
Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus.Q33859070
Nuclear lamins and neurobiologyQ34056472
Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblastsQ34072629
The nuclear envelope environment and its cancer connectionsQ34254678
Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequenceQ34309873
Nuclear deformability constitutes a rate-limiting step during cell migration in 3-D environmentsQ34568577
Nuclear mechanics during cell migration.Q34777149
Biophysical regulation of histone acetylation in mesenchymal stem cellsQ34800912
Accessorizing and anchoring the LINC complex for multifunctionalityQ34825870
Mechanical integration of actin and adhesion dynamics in cell migrationQ34990511
Multifunctional polymer scaffolds with adjustable pore size and chemoattractant gradients for studying cell matrix invasionQ35020911
Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin.Q35216800
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction.Q35632054
Direct inhibition of myosin II effectively blocks glioma invasion in the presence of multiple motogens.Q35756665
Nonpolarized signaling reveals two distinct modes of 3D cell migrationQ35925311
Lamins at a glanceQ36010368
Physical plasticity of the nucleus in stem cell differentiationQ36023764
The cellular mastermind(?)-mechanotransduction and the nucleusQ36113002
Nuclear mechanics in cancerQ36116300
Mechanics of the nucleusQ36144966
Fibroblasts Lead the Way: A Unified View of 3D Cell MotilityQ36236775
Physical confinement alters tumor cell adhesion and migration phenotypes.Q36252334
Differential basal-to-apical accessibility of lamin A/C epitopes in the nuclear lamina regulated by changes in cytoskeletal tensionQ36305787
Mechanical activation of cells induces chromatin remodeling preceding MKL nuclear transportQ36318027
Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopyQ36455433
Lamin A/C deficiency reduces circulating tumor cell resistance to fluid shear stressQ36498071
Mechanical regulation of nuclear structure and function.Q36617270
Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions.Q36708649
Nuclear positioningQ36765676
Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractilityQ37010867
The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcriptionQ37023583
Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesisQ37056635
Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation deviceQ37113994
Influence of lamin A on the mechanical properties of amphibian oocyte nuclei measured by atomic force microscopyQ37265569
cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteinsQ37397300
Actomyosin pulls to advance the nucleus in a migrating tissue cellQ37533446
Collagen-based cell migration models in vitro and in vivoQ37580117
Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrixQ37596116
Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival.Q37614860
Broken nuclei--lamins, nuclear mechanics, and disease.Q37678536
Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiationQ37686106
Microfabricated devices for cell biology: all for one and one for all.Q38063651
Do lamins influence disease progression in cancer?Q38190516
Leukocyte migration in the interstitial space of non-lymphoid organs.Q38193988
How to Measure Molecular Forces in Cells: A Guide to Evaluating Genetically-Encoded FRET-Based Tension SensorsQ38387139
Microfluidics: reframing biological enquiry.Q38571113
Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell StiffnessQ38838700
Microconstriction arrays for high-throughput quantitative measurements of cell mechanical propertiesQ38855502
Confinement and low adhesion induce fast amoeboid migration of slow mesenchymal cellsQ38909995
Role of suspended fiber structural stiffness and curvature on single-cell migration, nucleus shape, and focal-adhesion-cluster lengthQ38932800
Differential nuclear shape dynamics of invasive andnon-invasive breast cancer cells are associated with actin cytoskeleton organization and stabilityQ38972545
The effect of fibrillar matrix architecture on tumor cell invasion of physically challenging environmentsQ38994423
Cell jamming: collective invasion of mesenchymal tumor cells imposed by tissue confinement.Q39005469
Nuclear deformation during breast cancer cell transmigration.Q39302311
Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleus.Q39580612
Inhibition of hsp90 compromises the DNA damage response to radiationQ40230441
An alternative splicing product of the lamin A/C gene lacks exon 10.Q41205134
Dynamic force-induced direct dissociation of protein complexes in a nuclear body in living cells.Q42223382
Cancer cell migration in 3D tissue: negotiating space by proteolysis and nuclear deformabilityQ42250953
Hutchinson-Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substratesQ42826076
Mechanical stress-induced DNA damage and rac-p38MAPK signal pathways mediate p53-dependent apoptosis in vascular smooth muscle cellsQ44120985
Loss of lamin A/C expression in stage II and III colon cancer is associated with disease recurrenceQ44551732
Identification and cloning of an mRNA coding for a germ cell-specific A-type lamin in miceQ48081964
Cloning and sequencing of cDNA clones encoding chicken lamins A and B1 and comparison of the primary structures of vertebrate A- and B-type laminsQ48290157
A second higher vertebrate B-type lamin. cDNA sequence determination and in vitro processing of chicken lamin B2.Q48290261
A close-up view of migrating Langerhans cells in the skin.Q49023130
The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber.Q50671769
LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation.Q52633974
The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer.Q53080649
Lamins A and C but not lamin B1 regulate nuclear mechanics.Q53613002
Lamin A/C deficiency is an independent risk factor for cervical cancer.Q53784074
P304page(s)32-40
P577publication date2016-02-16
P1433published inCurrent Opinion in Cell BiologyQ13505682
P1476titleSquish and squeeze-the nucleus as a physical barrier during migration in confined environments
P478volume40

Reverse relations

cites work (P2860)
Q90706142A coupled approach for fluid saturated poroelastic media and immersed solids for modeling cell-tissue interactions
Q48247179Aggressive prostate cancer cell nuclei have reduced stiffness.
Q92983627An endocytic-secretory cycle participates in Toxoplasma gondii in motility
Q90478522Apicomplexan F-actin is required for efficient nuclear entry during host cell invasion
Q39154257Are cancer cells really softer than normal cells?
Q55223163Automated analysis of cell migration and nuclear envelope rupture in confined environments.
Q38891711Causes and consequences of nuclear envelope alterations in tumour progression
Q92732420Cell migration through three-dimensional confining pores: speed accelerations by deformation and recoil of the nucleus
Q41958762Connecting the plasma membrane to the nucleus by intermediate filaments
Q59794703Cytoskeletal control of nuclear migration in neurons and non-neuronal cells
Q91869885Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration
Q57050077Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures
Q58745588G9a Correlates with VLA-4 Integrin and Influences the Migration of Childhood Acute Lymphoblastic Leukemia Cells
Q92708952Genome organization in immune cells: unique challenges
Q90325049High-throughput microfluidic micropipette aspiration device to probe time-scale dependent nuclear mechanics in intact cells
Q50618815Increased chromatin plasticity supports enhanced metastatic potential of mouse melanoma cells.
Q48357964Lamin A and microtubules collaborate to maintain nuclear morphology
Q38698252Lamins in the nuclear interior - life outside the lamina
Q47262581Mechanoreciprocity in cell migration.
Q94544802Mechanosensing of Mechanical Confinement by Mesenchymal-Like Cells
Q55516137Micro and Nanofabrication methods to control cell-substrate interactions and cell behavior: A review from the tissue engineering perspective.
Q92451167Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization
Q92183061Modelling actin polymerization: the effect on confined cell migration
Q64951524Multicompartment cell-based modeling of confined migration: regulation by cell intrinsic and extrinsic factors.
Q38809211Multiple mechanisms of 3D migration: the origins of plasticity
Q64038729Non-canonical processes that shape the cell migration landscape
Q104073521Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina
Q92341904Novel K6-K14 keratin fusion enhances cancer stemness and aggressiveness in oral squamous cell carcinoma
Q36319488Nuclear Membrane-Targeted Gold Nanoparticles Inhibit Cancer Cell Migration and Invasion
Q37727547Nuclear morphologies: their diversity and functional relevance
Q92781335Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling
Q97530366Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis
Q47133845Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer
Q57283064Physical confinement alters sarcoma cell cycle progression and division
Q64882883Precise cell behaviors manipulation through light-responsive nano-regulators: recent advance and perspective.
Q58786959Quantitative phase imaging unravels new insight into dynamics of mesenchymal and amoeboid cancer cell invasion
Q91811377Recapitulation of molecular regulators of nuclear motion during cell migration
Q38768262Recent advances in understanding nuclear size and shape
Q47433774Regulation of genome organization and gene expression by nuclear mechanotransduction
Q59800862Role of Mechanotransduction and Tension in T Cell Function
Q64981806Shape and Size Control of Artificial Cells for Bottom-Up Biology.
Q58740843Skeletal Muscle Dystrophy mutant of lamin A alters the structure and dynamics of the Ig fold domain
Q33725650The "inherent vice" in the anti-angiogenic theory may cause the highly metastatic cancer to spread more aggressively.
Q96304809The Emerging Roles of Heterochromatin in Cell Migration
Q38998765The Mechanics of Single Cell and Collective Migration of Tumor Cells
Q59128386The Role of Melanoma Cell-Stroma Interaction in Cell Motility, Invasion, and Metastasis
Q48060921The nucleus is irreversibly shaped by motion of cell boundaries in cancer and non-cancer cells.
Q50732844Unbiased High-Precision Cell Mechanical Measurements with Microconstrictions.
Q63407154WDR5 modulates cell motility and morphology and controls nuclear changes induced by a 3D environment

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