Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet

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Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...869330M
P356DOI10.1371/JOURNAL.PONE.0069330
P932PMC publication ID3706421
P698PubMed publication ID23874946
P5875ResearchGate publication ID250926389

P2093author name stringMorichika Konishi
Nobuyuki Itoh
Yusuke Murata
Hiroya Ohta
Masaya Shimada
Takayuki Mochiyama
Kyoji Nishio
P2860cites workIdentification of a novel FGF, FGF-21, preferentially expressed in the liverQ22254289
FGF-21 as a novel metabolic regulatorQ24523933
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivoQ24632545
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation responseQ24653481
Functional evolutionary history of the mouse Fgf gene familyQ28259938
Torpor induction in mammals: recent discoveries fueling new ideasQ28749655
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic statesQ29615208
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21Q29615209
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)Q29615537
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistanceQ29622888
Glucocorticoids and insulin resistance: old hormones, new targetsQ33597180
Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosisQ34019712
A high-fat, ketogenic diet induces a unique metabolic state in miceQ79771171
Atkins and other low-carbohydrate diets: hoax or an effective tool for weight loss?Q34346120
Fibroblast growth factors: from molecular evolution to roles in development, metabolism and diseaseQ35020888
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesisQ35755169
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.Q35779219
Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivationQ36347755
Insulin sensitivity: modulation by nutrients and inflammationQ36848937
FGF21 reloaded: challenges of a rapidly growing fieldQ39798117
FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and PathophysiologyQ42176870
FGF21 is dispensable for hypothermia induced by fasting in miceQ43083439
Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH.Q43106855
Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver.Q51421300
Time dependence of insulin action in muscle and adipose tissue in the rat in vivo. An increasing response in adipose tissue with timeQ69908759
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectlow-carb high-fat dietQ10570030
preproinsulinQ7240673
adipocyteQ357519
P304page(s)e69330
P577publication date2013-07-09
P1433published inPLOS OneQ564954
P1476titleFgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet
P478volume8

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cites work (P2860)
Q50002410A Ketogenic Formula Prevents Tumor Progression and Cancer Cachexia by Attenuating Systemic Inflammation in Colon 26 Tumor-Bearing Mice
Q38370749A bioenergetics systems evaluation of ketogenic diet liver effects
Q39867543Altered Glycolysis and Mitochondrial Respiration in a Zebrafish Model of Dravet Syndrome
Q36061790Dietary restriction in obese children and its relation with eating behavior, fibroblast growth factor 21 and leptin: a prospective clinical intervention study
Q33749608Effects of Ketogenic Diets on Cardiovascular Risk Factors: Evidence from Animal and Human Studies.
Q26781556Endocrine FGFs: Evolution, Physiology, Pathophysiology, and Pharmacotherapy
Q64105434FGF21 as Modulator of Metabolism in Health and Disease
Q33851027FGF21 as a Hepatokine, Adipokine, and Myokine in Metabolism and Diseases
Q37485018FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice
Q49359562FGF21-induced by carbon monoxide mediates metabolic homeostasis via the PERK/ATF4 pathway
Q56688189Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis
Q37157508Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury
Q91851202Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric Ketogenic Diet
Q38817677High non-esterified fatty acid concentrations promote expression and secretion of fibroblast growth factor 21 in calf hepatocytes cultured in vitro.
Q35606508Ketogenic Diet Impairs FGF21 Signaling and Promotes Differential Inflammatory Responses in the Liver and White Adipose Tissue
Q47148295Ketogenic diet in endocrine disorders: Current perspectives
Q92229137Ketogenic diet induces skeletal muscle atrophy via reducing muscle protein synthesis and possibly activating proteolysis in mice
Q34109997Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice
Q38582878Novel Mediators of Adipose Tissue and Muscle Crosstalk
Q37694629Overfeeding Dairy Cattle During Late-Pregnancy Alters Hepatic PPARα-Regulated Pathways Including Hepatokines: Impact on Metabolism and Peripheral Insulin Sensitivity.
Q38296688Rapid increase in fibroblast growth factor 21 in protein malnutrition and its impact on growth and lipid metabolism.
Q26752330Roles of FGFs As Paracrine or Endocrine Signals in Liver Development, Health, and Disease
Q34467171The Fibroblast Growth Factor signaling pathway
Q92332250The mystery of the ketogenic diet: benevolent pseudo-diabetes