| P2093 | author name string | Matthew J Potthoff | |
| | Lucas D BonDurant | |
| P2860 | cites work | Identification of a novel FGF, FGF-21, preferentially expressed in the liver | Q22254289 |
| | betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c | Q24306279 |
| | Different roles of N- and C- termini in the functional activity of FGF21 | Q24312210 |
| | Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 | Q24318639 |
| | FGF21 N- and C-termini play different roles in receptor interaction and activation | Q24322074 |
| | FGF-21 as a novel metabolic regulator | Q24523933 |
| | Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting | Q24563197 |
| | Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State | Q24625976 |
| | Endocrine fibroblast growth factors 15/19 and 21: from feast to famine | Q24629260 |
| | Anti-Obesity Drugs: A Review about Their Effects and Safety | Q24630947 |
| | Dietary fructose and glucose differentially affect lipid and glucose homeostasis | Q24642206 |
| | The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids | Q24651464 |
| | FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response | Q24653481 |
| | BetaKlotho is required for metabolic activity of fibroblast growth factor 21 | Q24681531 |
| | FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases | Q27028013 |
| | Downstream signaling pathways in mouse adipose tissues following acute in vivo administration of fibroblast growth factor 21 | Q27308344 |
| | FGF21 promotes metabolic homeostasis via white adipose and leptin in mice | Q27335466 |
| | Bile Acid diarrhea: prevalence, pathogenesis, and therapy | Q28086845 |
| | Protein-dependent regulation of feeding and metabolism | Q28088330 |
| | FGF21 requires βklotho to act in vivo | Q28485347 |
| | Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes | Q28571616 |
| | FGF21 is an endocrine signal of protein restriction | Q28572009 |
| | Fundamentals of FGF19 & FGF21 action in vitro and in vivo | Q28729024 |
| | FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways | Q28741802 |
| | Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states | Q29615208 |
| | Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21 | Q29615209 |
| | Central nervous system control of food intake and body weight | Q29619020 |
| | FGF21 Is a Sugar-Induced Hormone Associated with Sweet Intake and Preference in Humans | Q29655262 |
| | FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms | Q38852382 |
| | Fibroblast growth factor 21 night watch: advances and uncertainties in the field | Q39017842 |
| | Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine | Q39042458 |
| | Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates. | Q47209022 |
| | The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity. | Q47300790 |
| | A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects | Q47319669 |
| | FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans. | Q47761142 |
| | Long-Term Cold Adaptation Does Not Require FGF21 or UCP1. | Q47813776 |
| | OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. | Q48290464 |
| | FGF21 and metabolic disease in 2016: A new frontier in FGF21 biology | Q48393385 |
| | FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting | Q48659709 |
| | Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling | Q50001768 |
| | FAP finds FGF21 easy to digest. | Q50858150 |
| | Metabolic pitfalls of CNS Cre-based technology. | Q50860964 |
| | Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework. | Q51278414 |
| | Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation. | Q51362717 |
| | FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists. | Q51582467 |
| | Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue. | Q53514538 |
| | Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex. | Q54468633 |
| | Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine | Q63609769 |
| | Beneficial effects of ketogenic diet in obese diabetic subjects | Q80188626 |
| | Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21 | Q84079985 |
| | KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference | Q30275308 |
| | Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake | Q30412686 |
| | FGF21 contributes to neuroendocrine control of female reproduction | Q30414627 |
| | Obesity: the protein leverage hypothesis. | Q31160720 |
| | FGF21 resistance is not mediated by downregulation of beta-klotho expression in white adipose tissue | Q33726498 |
| | Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence. | Q33773474 |
| | Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor? | Q33988652 |
| | Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis | Q34019712 |
| | Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse. | Q34197301 |
| | The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. | Q34306190 |
| | FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. | Q34315567 |
| | Novel locus including FGF21 is associated with dietary macronutrient intake | Q34325630 |
| | Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice | Q34350772 |
| | Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans | Q34403054 |
| | The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice | Q34408951 |
| | Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding. | Q34428501 |
| | The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21. | Q34577053 |
| | Central neural pathways for thermoregulation. | Q34636440 |
| | Co-receptor requirements for fibroblast growth factor-19 signaling | Q34665759 |
| | Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus | Q34699946 |
| | Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21. | Q34778879 |
| | Thermogenic activation induces FGF21 expression and release in brown adipose tissue. | Q34787051 |
| | Fibroblast growth factor 21 corrects obesity in mice | Q34805555 |
| | Fgf21 impairs adipocyte insulin sensitivity in mice fed a low-carbohydrate, high-fat ketogenic diet | Q34853883 |
| | Fructose ingestion acutely stimulates circulating FGF21 levels in humans | Q35040490 |
| | GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. | Q35086484 |
| | FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis | Q35755169 |
| | Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice | Q35763646 |
| | Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. | Q35779219 |
| | FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice | Q35886275 |
| | Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans | Q35929501 |
| | Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex | Q35947503 |
| | Elevated Serum Fibroblast Growth Factor 21 in Humans with Acute Pancreatitis | Q36188382 |
| | βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism | Q36248720 |
| | Neural circuits underlying thirst and fluid homeostasis | Q39389069 |
| | Understanding the physical interactions in the FGF21/FGFR/β-Klotho complex: structural requirements and implications in FGF21 signaling | Q39411644 |
| | Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21. | Q39581682 |
| | Overexpression of β-Klotho in Adipose Tissue Sensitizes Male Mice to Endogenous FGF21 and Provides Protection From Diet-Induced Obesity | Q39979332 |
| | Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. | Q40239037 |
| | Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. | Q40895648 |
| | Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1. | Q40958865 |
| | Fibroblast activation protein (FAP) as a novel metabolic target | Q41166927 |
| | Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency | Q41368114 |
| | Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance. | Q41760918 |
| | Genetic disruption of uncoupling protein 1 in mice renders brown adipose tissue a significant source of FGF21 secretion | Q41810632 |
| | The fasting polypeptide FGF21 can enter brain from blood | Q41875742 |
| | The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue | Q41912342 |
| | FGF21 mediates the lipid metabolism response to amino acid starvation. | Q42034608 |
| | Adipose-derived circulating miRNAs regulate gene expression in other tissues | Q42319316 |
| | A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response | Q42378996 |
| | Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states. | Q42813296 |
| | FGF21 attenuates lipolysis in human adipocytes - a possible link to improved insulin sensitivity | Q42813458 |
| | Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride | Q42950501 |
| | Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease. | Q42972684 |
| | Daily physical activity, fasting glucose, uric acid, and body mass index are independent factors associated with serum fibroblast growth factor 21 levels. | Q43010480 |
| | Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice | Q43224118 |
| | Response to carbohydrate and fat refeeding in the expression of genes involved in nutrient partitioning and metabolism: striking effects on fibroblast growth factor-21 induction. | Q43259536 |
| | Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity. | Q43287114 |
| | Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice | Q44504595 |
| | The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes | Q45834496 |
| | Circulating fibroblast growth factor 21 is induced by peroxisome proliferator-activated receptor agonists but not ketosis in man. | Q45966977 |
| | Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury | Q46120307 |
| | Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling | Q46195724 |
| | The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man. | Q46445480 |
| | Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice | Q46640076 |
| | FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes | Q47096943 |
| | FGF19, FGF21, and an FGFR1/β-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia | Q47183309 |
| | A Liver-Bone Endocrine Relay by IGFBP1 Promotes Osteoclastogenesis and Mediates FGF21-Induced Bone Resorption | Q36253842 |
| | A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. | Q36307444 |
| | FGF21 and the late adaptive response to starvation in humans | Q36335835 |
| | Genetics of food intake and eating behavior phenotypes in humans | Q36539517 |
| | FGF21 Regulates Sweet and Alcohol Preference. | Q36567992 |
| | FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver | Q36588765 |
| | Circulating FGF21 proteolytic processing mediated by fibroblast activation protein | Q36611366 |
| | Lessons on conditional gene targeting in mouse adipose tissue | Q36635274 |
| | Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21 | Q36674741 |
| | Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis | Q36746670 |
| | An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice | Q36886578 |
| | Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease | Q36889026 |
| | The structural biology of the FGF19 subfamily | Q36928572 |
| | The FGF family: biology, pathophysiology and therapy | Q36933339 |
| | FGF21 is an Akt-regulated myokine | Q37017459 |
| | Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2 | Q37116027 |
| | Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury | Q37157508 |
| | FGF21 regulates metabolism and circadian behavior by acting on the nervous system | Q37161082 |
| | A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution | Q37217436 |
| | Fibroblast growth factor 21 has no direct role in regulating fertility in female mice | Q37253435 |
| | FGF21 is not required for glucose homeostasis, ketosis or tumour suppression associated with ketogenic diets in mice | Q37485018 |
| | Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates | Q37571417 |
| | A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. | Q37571422 |
| | What we talk about when we talk about fat. | Q37601812 |
| | FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders | Q37610032 |
| | FGF21-based pharmacotherapy--potential utility for metabolic disorders | Q38202720 |
| | FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues | Q38293953 |
| | Development of a novel long-acting antidiabetic FGF21 mimetic by targeted conjugation to a scaffold antibody | Q38315161 |
| | Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance | Q38330457 |
| | Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects | Q38351110 |
| | Sweet Sixteenth for ChREBP: Established Roles and Future Goals | Q38648009 |
| | Understanding the Physiology of FGF21. | Q38665376 |
| | Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action | Q38723347 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 173-196 | |
| P577 | publication date | 2018-05-04 | |
| P1433 | published in | Annual Review of Nutrition | Q4769675 |
| P1476 | title | Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis | |
| P478 | volume | 38 | |