Mouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable

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Mouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1052540660
P356DOI10.1038/ONC.2008.465
P932PMC publication ID2667867
P698PubMed publication ID19137014
P5875ResearchGate publication ID23771241

P2093author name stringV W Yang
W B Dalton
A B Bialkowska
A M Ghaleb
E G Hagos
P2860cites workIdentification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrestQ24311735
A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cellsQ24322959
Centrosome amplification drives chromosomal instability in breast tumor developmentQ24534950
Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferationQ24535046
The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiologyQ24647882
Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiationQ24648756
The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoterQ24653488
Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damageQ24655032
Quantitative studies of the growth of mouse embryo cells in culture and their development into established linesQ24683034
Mad2 overexpression promotes aneuploidy and tumorigenesis in miceQ24684680
Sp1- and Krüppel-like transcription factorsQ24804528
Klf4 is a transcription factor required for establishing the barrier function of the skinQ28115084
Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cellsQ36953179
Oncogenes and tumour suppressors take on centrosomesQ37001380
Cytogenetic methods for the mouse: preparation of chromosomes, karyotyping, and in situ hybridizationQ38025435
Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpressionQ40534917
Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathwayQ40796712
Deregulated cyclin E induces chromosome instabilityQ41692394
A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication.Q42808356
The centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that might benefit from aurora kinase inhibitionQ46897627
Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice.Q52212492
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrationsQ56114798
Aneuploidy and cancerQ56224730
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient miceQ62088781
Microtubule dynamicsQ69702729
Genomic instability and apoptosis are frequent in p53 deficient young miceQ73743370
Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activationQ80149163
Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomachQ81640280
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
Genetic instabilities in human cancersQ28131826
Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycleQ28366322
Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesisQ28592219
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpointsQ29617405
Human cancer cells commonly acquire DNA damage during mitotic arrestQ30481316
Aneuploidy of human testicular germ cell tumors is associated with amplification of centrosomes.Q33187451
Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrationsQ33884941
The biology of the mammalian Krüppel-like family of transcription factorsQ33929897
Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.Q33940550
Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancerQ33952921
Krüppel-like factors: three fingers in many piesQ34083303
Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damageQ34092984
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.Q34128767
The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.Q34164259
Beyond self-assembly: from microtubules to morphogenesisQ34181655
Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancerQ34290018
Abnormal centrosome amplification in the absence of p53.Q34374717
Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progressionQ34408251
Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damageQ34408376
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogeneQ34462232
KLF4, p21 and context-dependent opposing forces in cancerQ34478868
Does aneuploidy cause cancer?Q34574496
Loss of Krüppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progressionQ34579406
Centrosome amplification and the development of cancerQ34818152
Two for two: Cdk2 and its role in centrosome doublingQ34818166
Loss of p53 and centrosome hyperamplification.Q34818333
Aneuploidy: instigator and inhibitor of tumorigenesisQ35094418
Altered centrosome structure is associated with abnormal mitoses in human breast tumorsQ35787940
Centrosome amplification and the origin of chromosomal instability in breast cancerQ35959371
Centrosome amplification, chromosome instability and cancer developmentQ36298974
Krüppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damageQ36438918
Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patientsQ36497091
The Pathobiology of Krüppel-like Factors in Colorectal CancerQ36672289
Tetraploidy, aneuploidy and cancerQ36745868
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1197-1205
P577publication date2009-01-12
P1433published inOncogeneQ1568657
P1476titleMouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable
P478volume28

Reverse relations

cites work (P2860)
Q92688212A distinct epigenetic program underlies the 1;7 translocation in myelodysplastic syndromes
Q34107480A small ubiquitin-related modifier-interacting motif functions as the transcriptional activation domain of Krüppel-like factor 4.
Q49372792Aging and the Krüppel-like factors
Q46555655Contrasting effects of Krüppel-like factor 4 on X-ray-induced double-strand and single-strand DNA breaks in mouse astrocytes
Q93065274DNA Methylation Readers and Cancer: Mechanistic and Therapeutic Applications
Q21198852Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development
Q39145565Epigenetic alterations of Krüppel-like factor 4 and its tumor suppressor function in renal cell carcinoma
Q35191041Expression profiling and pathway analysis of Krüppel-like factor 4 in mouse embryonic fibroblasts
Q38111773Genomic instability and colon carcinogenesis: from the perspective of genes
Q35576730Impaired autophagy in mouse embryonic fibroblasts null for Krüppel-like Factor 4 promotes DNA damage and increases apoptosis upon serum starvation
Q33899036KLF family members regulate intrinsic axon regeneration ability.
Q35633784KLF4α Up-regulation Promotes Cell Cycle Progression and Reduces Survival Time of Patients With Pancreatic Cancer
Q38031130Kruppel-like factors and vascular inflammation: implications for atherosclerosis
Q91872152Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence
Q39151066Krüppel-like factor 4 (KLF4): What we currently know
Q34448860Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice.
Q21245753Krüppel-like factor 4 regulates genetic stability in mouse embryonic fibroblasts
Q24612560Mammalian Krüppel-Like Factors in Health and Diseases
Q37193068Mechanisms of chromosomal instability.
Q58744702Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions
Q38999451Oxidative DNA damage causes premature senescence in mouse embryonic fibroblasts deficient for Krüppel-like factor 4.
Q24617620Prognostic value and function of KLF4 in prostate cancer: RNAa and vector-mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration

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